Lupus myelopathy in a child

SLE‐associated myelitis successfully treated by rituximab

“… 8 Despite early reports, TM may be presenting symptom of SLE. 4 , 9 , 10 Zhang et al in a cohort of SLE‐TM patients reported that in 50% of these patients TM is the initial manifestation of SLE. 11 They reported no significant difference in the demographic characteristics of patients with and without TM.…”

Acute longitudinal myelitis as the first presentation in child with systemic lupus erythematosus

“…ATM is seen in 1-2% of SLE patients, but in one adult study it is reported to be a presenting feature in up to 39% of SLE patients. [134] Most patients who develop complications of ATM do so within 5 years of SLE diagnosis. ATM in SLE may present with the classical picture of motor weakness, sensory disturbance, and sphincter disturbances.…”

“…Investigation may reveal raised inflammatory markers in blood as well as CSF. [3467] The auto-antibody screen may show antibodies positive suggesting SLE but with no clinical features to correlate. The diagnosis of SLE is made after excluding other possible causes of ATM and with lab data suggesting SLE.…”

“…[410] This combination of treatment seems to show better response. But the prognosis is generally perceived to be poor in those with SLE.…”

“…Those with hyper acute symptoms at onset, positive ANA, or those caused by connective disease have poor outcome. [45]…”