Lupus Nephritis diagnosed by stand-alone renal histopathological findings in a middle-aged male.

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune condition, characterized by the production of autoantibodies, predominantly against nuclear antigens. It primarily affects women of childbearing age. Men account for 4-22% of all cases in various series (1,2). Lupus nephritis can be diagnosed with high sensitivity and specificity based on histopathological criteria alone (3). We report lupus nephritis in a 50-year-old male diagnosed solely on renal histopathological findings.

Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy – one-center preliminary study

“…Testing for TRIs is a valuable clue in cases where the diagnosis of SLE is not fully established and the clinical manifestation of lupus is nonspecific, which is often seen in pediatric cases [11,16,22]. An interesting example of the role of TRIs in making a final diagnosis is the case According to the Mayo Clinic recommendations, TEM examination should be permanently included in the generally applicable guidelines for assessment of renal biopsies in LN [12].…”

“…The attempt to explain the importance of TRIs in LN has a long history, but their diagnostic, pathophysiological, and prognostic role has not been clearly defined so far [ 13 , 17 ]. The presence of TRIs in the endothelial cells of the glomerular capillaries is considered a very important morphological marker of LN, especially in pediatric cases [ 11 , 16 , 22 ]. TRIs are sometimes called ‘interferon footprints’ because they are considered markers of the IFN pathway [ 13 ].…”

“…Testing for TRIs is a valuable clue in cases where the diagnosis of SLE is not fully established and the clinical manifestation of lupus is nonspecific, which is often seen in pediatric cases [ 11 , 16 , 22 ]. An interesting example of the role of TRIs in making a final diagnosis is the case of a patient whose first and only manifestation of developing lupus was a severe drug-resistant depressive disorder.…”