Lupus nephritis in childhood: a review of 53 patients followed at a single center

Bogdanović, Radovan; Nikolić, V; Pašić, Srdjan; Dimitrijević, J; Lipkovska-Marković, Jasmina; Erić-Marinković, Jelena; Ognjanović, Miloš; Minic, Aleksandra; Stajić, Nataša

doi:10.1007/s00467-003-1278-y

Cited by 133 publications

(150 citation statements)

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“…[22] Bakr [14] reported a low frequency of neuropsychiatric abnormalities in children with SLE. However, our study, similar to reports coming from Saudi Arabia [12] and western countries, [9,19,20] pointed to a higher frequency of CNS abnormalities.…”

Section: Discussionsupporting

confidence: 91%

“…The clinical manifestations of our patients with LN were similar to those seen in studies of children of the western countries. [9,11,13,20] In this study, LN was evident at the time of diagnosis in all patients except four, who proceeded to develop LN within a year.…”

Section: Discussionmentioning

confidence: 48%

“…[10,12,14,17,18] Previous studies found that the majority of children with SLE were over 10 years of age. [12,14,19,20] The onset of SLE is rare before the age of five. [21] Font et al [9] reported that one out of 34 patients presented clinical manifestations of SLE at the age of five, but none of their patients presented these manifestations before this age.…”

Section: Discussionmentioning

confidence: 99%

“…Nephrotic proteinuria was defined as protein >1 g/m 2 in a 24-hour urine collection. [20] Serum creatinine >1 mg/dl was considered abnormal. [14] A biopsy was usually performed within one to two months of clinical diagnosis.…”

Section: Methodsmentioning

confidence: 99%

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Juvenile Lupus Erythematosus: Fourteen Years of Experience

et al. 2011

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Amaç: Bu çalışmada Türk çocuklarda juvenil sistemik lupus eritematozusa (JSLE) ilişkin temel klinik ve laboratuvar özellikler ve yanı sıra morbidite ve mortalitenin tanımlanması amaçlandı. Hastalar ve yöntemler:Otuz JSLE'li çocuk (27 kız, 3 erkek; ort. tanı yaşı 12.3 yıl; dağılım 3-16 yıl) retrospektif olarak değerlendirildi. Hastaların hepsi SLE tanısına ilişkin revize edilmiş 1982 Amerikan Romatoloji Birliği kriterlerini karşılamaktaydı ve 16 yaşından önce hastalığın klinik bulgularını sergilemişti. Bulgular: Ortalama takip süresi 2.9 yıl (dağılım 2 ay-10 yıl), tanı öncesi semptomların ortalama süresi ise 3.3 ay (dağılım 2 gün-2 yıl) idi. Hastaların klinik ve laboratuvar özelliklerinin sıklığı şöyle idi: eritematöz malar döküntü 17 (%56), discoid döküntü bir (%3.3), fotosensitivite 16 (%53.3), oral ülser sekiz (%26.7), kas-iskelet tutulumu 26 (%87), serözit 13 (%43), hematolojik anormallikler 21 (%70), renal tutulum 17 (%56), antinükleer antikor pozitifliği 27 (%93), pulmoner tutulum sekiz (%27), kardiyovasküler hastalık yedi (%23) ve merkezi sinir sistemi tutulumu yedi (%23) hastada görüldü. İzlem sırasında üçü böbrek yetmezliğinden, biri sepsisten olmak üzere dört hasta öldü (%13). Çalışma sırasında iki hasta tedavisiz remisyonda, 22 hasta ise tedavi ile remisyonda takip edilmekte idi. İki hasta ise takipten çıkmış idi.Sonuç: Juvenil sistemik lupus eritematozus ciddi, multisistemik bir organ hastalığıdır. JSLE erken tanı ve tedavi ile yüksek bir remisyon oranı sergilemesine karşın, hala önemli bir mortalite oranına sahiptir.Anahtar sözcükler: Juvenil; lupus nefriti; sonuç; sistemik lupus eritematosus; tedavi.Objectives: This study aims to describe the main clinical and laboratory features as well as the morbidity and mortality of juvenile systemic lupus erythematosus (JSLE) in Turkish children. Patients and methods:Thirty children (27 girls, 3 boys; mean age at diagnosis 12.3 years; range 3 to 16 years) with JSLE were evaluated retrospectively. All patients met the 1982 American College of Rheumatology revised criteria for the diagnosis of SLE and had shown clinical manifestations of the disease before the age of 16. Results:The mean period of follow-up was 2.9 years (range 2 months-10 years) and the mean duration of symptoms before diagnosis was 3.3 months (range 2 days-2 years). The frequencies of the clinical and laboratory features of the patients were as follows: erythematous malar rash was seen in 17 (56%), discoid rash in one, photosensitivity in 16 (53.3%), oral ulcers in eight (26.7%), musculoskeletal involvement in 26 (87%), serositis in 13 (43%), hematological abnormalities in 21 (70%), renal involvement in 17 (56%), antinuclearantibody positivity in 27 (93%), pulmonary involvement in eight (27%), cardiovascular disease in seven (23%), and central nervous system involvement in seven patients (23%). During the follow-up four patients (13%) died, three of renal failure and one from sepsis. During the study two patients were in remission without treatment and 22 patients were in remission with treatm...

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Juvenile Lupus Erythematosus: Fourteen Years of Experience

et al. 2011

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“…14,20,21 La prevalencia de nefritis en niños fue menor a la reportada en Medio Oriente y en Estados Unidos 18,22,23 pero, aún así, fue significativamente mayor que en los adultos. Los factores de mal pronóstico para niños con nefritis lúpica incluyen: proteinuria persistente, hipertensión arterial al inicio de la enfermedad, falta de remisión completa en el primer año de tratamiento, nivel de C3 bajo, creatinina elevada y origen étnico no caucásico; además de una clasificación histológica grados IV-V.…”

Section: Discussionunclassified

Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos

2018

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Este artículo debe citarse comoCoronado-Alvarado CD, Gámez-Saiz IL, SoteloCruz N. Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos. Acta Pediatr Mex. 2018;39(1):1-12. Recibido: 20 de octubre del 2016 Aceptado: 4 de abril del 2017Resumen INTRODUCCIÓN: el lupus eritematoso sistémico es una enfermedad autoinmune crónica; se presenta mayormente en mujeres en etapa reproductiva y es menos frecuente en niños.OBJETIVO: comparar las manifestaciones clínicas, comorbilidades y farmacoterapia en niños y adultos con lupus eritematoso sistémico (LES). MATERIAL Y MÉTODOS:se seleccionaron 127 expedientes clínicos de pacientes con diagnóstico de LES; 36 menores de edad de un hospital pediátrico (grupo A) y 91 adultos de un hospital general (grupo B). Recolectamos información respecto a las manifestaciones clínicas al diagnóstico en los niños y adultos, así como las comorbilidades relacionadas y mortalidad, atendiendo los criterios de la American College of Rheumatology, también del tipo de medicamentos empleados. Estadísticas utilizadas: cálculo de frecuencias, porcentajes, la prueba de ji cuadrada, prueba exacta de Fisher, razón de momios e intervalos de confianza.RESULTADOS: en niños predominaron: eritema malar (p = < 0.01), vasculitis (p < 0.01), fotosensibilidad (p < 0.01), síndrome nefrítico (p < 0.01), alteraciones leucocitarias (p < 0.01), derrame pleural, anemia, derrame pericárdico, sepsis y hepatopatía; además, el número de medicamentos empleados fue mayor. En adultos predominaron: artralgia (p < 0.01), pancitopenia (p = 0.025), alopecia (p < 0.01), sinovitis (p = 0.044) y falla renal crónica (p = 0.04). Los fármacos usados en el grupo A fueron: hidroxicloroquina (p < 0.01), glucocorticoides (p = 0.14) y micofenolato (p = 0.28), la mortalidad en niños fue de 25% y en 91 adultos ocurrió en 5 (0.05%).CONCLUSIONES: las manifestaciones clínicas en niños muestran mayor lesión cutánea inicial y vasculitis, daño renal, cardiovascular, pulmonar e infecciones; en los adultos predominan afecciones articulares y falla renal crónica. Los niños reciben mayor número de fármacos y su mortalidad es mayor.PALABRAS CLAVE: lupus eritematoso sistémico, manifestaciones clínicas, niños, adultos.

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Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus and Juvenile Dermatomyositis

Eleftheriou¹,

Woo

2011

Harper's Textbook of Pediatric Dermatology

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Lupus nephritis in childhood: a review of 53 patients followed at a single center

Abstract: We retrospectively evaluated the clinical and histopathological features, treatment modalities, and out

Cited by 133 publications

References 49 publications

Juvenile Lupus Erythematosus: Fourteen Years of Experience

Juvenile Lupus Erythematosus: Fourteen Years of Experience

Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos

Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus and Juvenile Dermatomyositis

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