Lupus nephritis in males; updates to current knowledge

Shaukat, Faizan; Russinova, Liliya; Seizhanova, Bagzhan; Rakhmetova, Assel

doi:10.15171/npj.2019.09

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Additionally, different types of lupus nephritis appear to be driven by differing cytokine profiles. Whereas Th1-mediated inflammation promotes diffuse lupus nephritis, seen more commonly in males, Th2 responses result in membranous lupus nephritis, which is more common in females ( 166 , 167 ). Skin lesions in lupus, also more common in females, are triggered by Th2 cells, which subsequently transition to a Th1-like phenotype as a result of increased TLR7 signaling ( 168 , 169 ).…”

Section: Sex Bias In Lymphocytes In Autoimmune Diseasesmentioning

confidence: 99%

Sex bias in lymphocytes: Implications for autoimmune diseases

Dodd

Menon

2022

Front. Immunol.

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Autoimmune diseases are characterized by a significant sex dimorphism, with women showing increased susceptibility to disease. This is, at least in part, due to sex-dependent differences in the immune system that are influenced by the complex interplay between sex hormones and sex chromosomes, with contribution from sociological factors, diet and gut microbiota. Sex differences are evident in the number and function of lymphocyte populations. Women mount a stronger pro-inflammatory response than males, with increased lymphocyte proliferation, activation and pro-inflammatory cytokine production, whereas men display expanded regulatory cell subsets. Ageing alters the immune landscape of men and women in differing ways, resulting in changes in autoimmune disease susceptibility. Here we review the current literature on sex differences in lymphocyte function, the factors that influence this, and the implications for autoimmune disease. We propose that improved understanding of sex bias in lymphocyte function can provide sex-specific tailoring of treatment strategies for better management of autoimmune diseases.

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Section: Sex Bias In Lymphocytes In Autoimmune Diseasesmentioning

confidence: 99%

Sex bias in lymphocytes: Implications for autoimmune diseases

Dodd

Menon

2022

Front. Immunol.

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Candidate MicroRNA Biomarkers in Lupus Nephritis: A Meta-analysis of Profiling Studies in Kidney, Blood and Urine Samples

et al. 2022

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Lupus nephritis (LN) is a kidney disease caused by systemic lupus erythematosus in which kidneys are attacked by the immune system. MiRNAs participate in the pathogenesis of LN as modulatory effectors in immune responses and nephrogenesis pathways. Despite the large number of miRNAs that are expressed deferentially, identifying the most suitable biomarker candidate for LN is challenging. The aim of this study was to introduce a consensus panel of potential miRNA biomarkers by performing a meta-analysis of miRNA pro les in the kidney, blood, and urine samples of LN patients. A comprehensive literature review approach was considered to nd LN-related miRNA expression pro les. After including the 41 eligible studies and performing the data extraction, metaanalysis was done based on the vote-counting rank strategy and as well as meta-analysis of p-value. The result of the meta-analysis was three lists of consensus miRNAs with altered expression pro les in the various tissue samples of LN patients. Of the 13 studies on kidney tissue, the meta-miRNAs were let-7a, miR-198, let-7e, miR-145, and miR-26a. In addition, meta-miRNAs of miR-199a, miR-21, miR-423, miR-1260b, miR-589, miR-150, miR-155, miR-146a, and miR-183 from 21 studies on blood samples, and miR-146a, miR-204, miR-30c, miR-3201, and miR-1273e from 11 studies on urine samples can be considered as non-invasive biomarker panels for LN. The meta-miRNAs and their related genes were subjected to functional enrichment analyses and network construction. Functional enrichment analysis con rmed the involvement of their target genes in nephropathy-related signaling pathways. Network construction showed miR-145-5p in blood and miR-155-5p in kidney, the best hob miRNAs as candidate drug targets. In conclusion using a meta-analysis approach, our study proposes three meta-miRNA panels that could be the target of further research to assess their potential as biomarkers / therapeutic targets in LN disease.

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Lupus nephritis in males; updates to current knowledge

Abstract: Although some studies showed a significant increase in lupus nephritis among male systemic lupus erythematosus patients, others showed no difference or contradicting results. Hence, we suggest further studies comparing the disease manifestations between the two genders.

Cited by 2 publications

References 12 publications

Sex bias in lymphocytes: Implications for autoimmune diseases

Sex bias in lymphocytes: Implications for autoimmune diseases

Candidate MicroRNA Biomarkers in Lupus Nephritis: A Meta-analysis of Profiling Studies in Kidney, Blood and Urine Samples

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