Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine

Sharma, Raghubir P.; He, Qingliang; Riley, Ronald T.

doi:10.1016/j.tox.2005.07.024

Cited by 9 publications

(3 citation statements)

References 57 publications

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“…For example, treating these mice with interferon accelerates disease in a T-cell like manner (Z. Liu, et al, 2010;Mathian, et al, 2005), while knocking out or inhibiting interferon-related genes slows or eliminates the development of lupus-like symptoms (Jorgensen, et al, 2007;Sharma, et al, 2005). These mice have been used to clarify the interactions between sex hormones and www.intechopen.com interferon in lupus etiology (Bynote, et al, 2008;Panchanathan, et al, 2009;Panchanathan, et al, 2010), and they serve as an excellent all-around model for spontaneous development of lupus.…”

Section: Mouse Models Allow the Study Of Ifn And Apoptosis Pathwaysmentioning

confidence: 99%

Interferon and Apoptosis in Systemic Lupus Erythematosus

Clark¹,

Poole²

2012

Systemic Lupus Erythematosus

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Section: Mouse Models Allow the Study Of Ifn And Apoptosis Pathwaysmentioning

confidence: 99%

Interferon and Apoptosis in Systemic Lupus Erythematosus

Clark¹,

Poole²

2012

Systemic Lupus Erythematosus

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“…Ceramides, sphingoids [17][18][19] and their metabolites have been discussed as rheostats of cellular signals [20][21][22] . In fact, several reports are available on FB1-mediated alterations in cellular signals accompanying the changes in ceramide and sphingoid levels [23][24][25] . In spite of extensive elaborative researches, causal mechanisms of FB1 toxicity remain obscure in vivo in animal species.…”

Section: Introductionmentioning

confidence: 99%

Possible Role of Phosphatidylcholine and Sphingomyelin on Fumonisin B1-mediated Toxicity

2017

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A major corn-related mycotoxin, fumonisin B1 (FB1), continues to attract attention of researchers as well as risk-assessors due to the diverse toxicological characteristics, including distinct target tissues in different animal species and opposite susceptibility in males and females in mice and rats. More than thirty years passed since the structure identification as a sphingoid-like chemical, but the causal mechanism of the toxicity remains obscure in spites of extensive studies. Considerable amounts of knowledge have been accumulated on the biochemical/toxicological actions of FB1, but the influence on lipid dynamics and mobilization in the body has not been focused well in relation to the FB1-mediated toxicity. Considerable influences of this toxin on mobilization of sphingolipids and phospholipids and also on adaptive changes in their compositions in tissues are implicated from recent studies on FB1-interacting ceramide synthases. Accumulated patho-physiological data also suggest a possible role of hepatic phospholipid on FB1-mediated toxicity. Thus, a mechanism of FB1-mediated toxicity is discussed in relation to the mobilization of phospholipids and sphingolipids in the body in this context.

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“…Estes animais desenvolvem espontaneamente o LES, permitindo a observação e o estudo do desenvolvimento da doença e seus possíveis agravantes, terapias e mecanismos fisiopatológicos (Tejon et al, 2019). Esta linhagem já foi utilizada em diversos estudos relacionados ao LES, constatando ser um modelo eficiente no estudo da doença (Sharma et al, 2005;Wang & Sun., 2019).…”

Section: Modelo Experimentalunclassified

Efeito da exposição crônica ao material particulado fino no tecido cardíaco de camundongos predispostos ao Lúpus Eritematoso Sistêmico

Waked¹

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mim durante o período do mestrado e por toda ajuda, força e atenção nos momentos de ansiedade. Obrigada por todos os ensinamentos, conselhos e oportunidades durante os últimos anos. Deixo aqui minha gratidão e admiração.Às minhas amigas e parceiras de laboratório, Thamires Moraes e Ana Clara Bastos, agradeço a amizade, companheirismo e apoio de vocês. Todos os cafés, conversas e desabafos deixaram essa caminhada mais leve.Aos demais colegas e colaboradores, Victor Yariwake, Gabriel Pereira, Felipe Pereira, Roberta Foster e Álvaro Pelegrin, obrigada por todos os momentos divertidos, experimentos e incentivos, em especial ao Victor por toda ajuda, correções e esclarecimentos durante esse estudo.Aos meus colegas de pós-graduação, Denival Junior, Aline Parletta, Tabatha Oliveira e Guilherme Lunardon, que mesmo à distância nunca deixaram de me apoiar, agradeço toda ajuda e amizade de vocês.A todos os funcionários do laboratório pelo auxílio e cuidado de sempre, e à Faculdade de medicina da Universidade de São Paulo (FMUSP) pela infraestrutura e apoio institucional.À Deus por toda graça, por me guiar e proteger em todos os momentos, e até aqui ter me sustentado.À toda minha família pelo apoio e acolhimento, em especial ao meu Pai Samir Waked, que sempre foi meu maior incentivador na carreira cientifica, à minha Mãe e Irmã, Graça Waked e Adila Waked, amo todos vocês! À Penelope, José, Julie, Sky e Milly por serem a minha válvula de escape e estarem comigo nos momentos mais difíceis.

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Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine

Cited by 9 publications

References 57 publications

Interferon and Apoptosis in Systemic Lupus Erythematosus

Interferon and Apoptosis in Systemic Lupus Erythematosus

Possible Role of Phosphatidylcholine and Sphingomyelin on Fumonisin B1-mediated Toxicity

Efeito da exposição crônica ao material particulado fino no tecido cardíaco de camundongos predispostos ao Lúpus Eritematoso Sistêmico

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