Abstract:Objective: We have shown that sole increase of interferon alpha (IFNα) in tetracycline-inducible transgenic (IFNα Tg) mice induces production of anti-dsDNA antibody and renal disease akin to human SLE. It has also been reported that IFNα is highly expressed in the brain and cerebrospinal fluids in patients with lupus psychosis. In this study, we have studied the contribution of IFNα to neuropsychiatric disease. Method: We made C57BL6/FVBN TetOp-mIFNα/EμSR-tTA transgenic female mice in which IFNα was expressed … Show more
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