Lupus Vasculopathy Combined with Renal Infarction: Unusual Manifestation of Lupus Nephritis

Sugimoto, Toshiro; Kanasaki, Keizo; Morita, Yoshikata; Yokomaku, Yukiyo; Narita, Mitsuhiro; Koyama, Tsunemaro; Tanaka, Yuki; Kashiwagi, Atsunori; Koya, Daisuke

doi:10.2169/internalmedicine.44.1185

Cited by 5 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, only one report of renal infarction due to lupus vasculopathy has been published. 8 In the report of Sugimoto et al., 8 the renal biopsy revealed only mild glomerular cell proliferation and there was no glomerular tuft necrosis and crescents.…”

Section: Discussionmentioning

confidence: 93%

“…The types of vascular lesions identified in SLE are: uncomplicated vascular immune deposits, lupus vasculopathy (also called non-inflammatory necrotizing vasculopathy and immunoglobulin microvascular casts), thrombotic microangiopathy (TMA), arteriosclerosis and arteriolosclerosis and necrotizing vasculitis (true renal vasculitis). 2,3,8…”

Section: Discussionmentioning

confidence: 99%

“…Immune complexes are not found in TMA. 3,8 TMA is usually associated with antiphospholipid syndrome or haemolytic-uraemic syndrome/thrombotic thrombocytopenic purpura. The lesions of necrotizing vasculitis include focal or circumferential, often transmural, prominent infiltration of the blood vessel wall with inflammatory cells such as lymphocytes, monocytes and neutrophils.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Renal infarction due to lupus vasculopathy

Varalaxmi

Sandeep

Sridhar

et al. 2015

Lupus

View full text Add to dashboard Cite

In the ISN/RPS 2003 classification of lupus nephritis (LN) renal vascular lesions are not mentioned. We present a patient with postpartum lupus vasculopathy. The renal biopsy in our patient showed concentric intimal thickening with narrowed lumen. No inflammatory changes were found. It also revealed immunoglobulin and complement deposition on the wall of the arteriole. These changes indicate lupus vasculopathy. The glomeruli revealed diffuse proliferative glomerulonephritis, with wire loops and cellular crescent in one glomerulus. The patient showed improvement with immunosuppression.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Renal infarction due to lupus vasculopathy

Varalaxmi

Sandeep

Sridhar

et al. 2015

Lupus

View full text Add to dashboard Cite

show abstract

“…Although previous cases of lupus vasculopathy were mainly treated with immunosuppressive therapy because of coincidental active lupus involvement or its hypothesized mechanism, it has not been established whether conventional immunosuppressive agents are effective [1, 10]. Sugimoto et al reported a case of renal lupus vasculopathy without active glomerular lesions successfully treated without immunosuppressive therapy [16]. The patient, who had a previous medical history of central nervous system lupus, developed acute renal infarction and multiple arterial stenoses in the interlobular arteries.…”

Section: Discussionmentioning

confidence: 99%

Large vessel vasculopathy in a patient with systemic lupus erythematosus: a case report

2019

View full text Add to dashboard Cite

Background Vasculopathy in systemic lupus erythematosus is a rare form of vascular involvement characterized by non-inflammatory vascular injury with the accumulation of immune complexes in the walls of the arteries, resulting in luminal narrowing. While previous reports have demonstrated vasculitis in the large vessels or vasculopathy in the small vessels, vasculopathy in large vessels has not yet been reported. Case presentation We present the case of a 43-year-old Japanese woman with peripheral large vessel vasculopathy associated with systemic lupus erythematosus. She presented a 7-year history of progressive headaches and intermittent claudication, although she had no atherosclerotic risk factors. Vascular ultrasonography and enhanced computed tomography showed multiple vascular stenoses and occlusion. The histological findings of her left temporal artery revealed narrowing of the lumen caused by intimal thickening without inflammatory cells and the deposition of immunoglobulin G, complement component 3, and fibrinogen in the wall of the intima. Beraprost and cilostazol improved arterial occlusion without immunosuppressive therapy. Conclusions Large vessel vasculopathy should be considered another potential cause of arterial stenoses and occlusion in patients with lupus when they have peripheral arterial disease despite having no atherosclerotic risk factors.

show abstract

“…Such vasculopathy of the spiral arteries is defined by fibrinoid necrosis of the vessel wall, accumulation of lipid-laden macrophages, and a mononuclear perivascular infiltrate [21]. Interestingly, similar vascular lesions have been observed in the vessels of patients with autoimmune diseases such as lupus vasculopathy [22], and in renal, cardiac and hepatic transplant-graft rejection [21]. Immunofluorescence analysis reveals extensive vascular deposition of non-specific IgM and complement in these lesions [23].…”

Section: Basic Pathology and Physiology Of Preeclampsiamentioning

confidence: 99%

The biology of preeclampsia

Kanasaki

Kalluri

2009

Kidney International

Self Cite

143

109

View full text Add to dashboard Cite

Preeclampsia is a systemic disease that results from placental defects and occurs in about 5–8% of pregnancies worldwide. Preeclampsia is a disease of many theories, wherein investigators put forward their favorite mechanistic ideas, each with a causal appeal for the pathogenesis of preeclampsia. In reality, the patho-mechanism of preeclampsia remains largely unknown. Preeclampsia, as diagnosed in patients today, is likely a heterogeneous collection of disease entities that share some common features but also exhibit important differences. Therefore, one single mechanism may never be found to explain all the variants of preeclampsia. Current research must focus on evaluating such diverse mechanisms, as well as the possible common effectors pathways. Here we provide a discussion of several possible mechanisms and putative theories proposed for preeclampsia, with particular emphasis on the recent discovery of a new genetic mouse model offering new opportunities to explore experimental therapies.

show abstract

Lupus Vasculopathy Combined with Renal Infarction: Unusual Manifestation of Lupus Nephritis

Cited by 5 publications

References 9 publications

Renal infarction due to lupus vasculopathy

Renal infarction due to lupus vasculopathy

Large vessel vasculopathy in a patient with systemic lupus erythematosus: a case report

The biology of preeclampsia

Contact Info

Product

Resources

About