Lurasidone in schizophrenia in adolescents: a profile of its use

An efficient method for the synthesis of 7H-benzo[4,5]isothiazolo[3,2-b]quinazolin-7-ones from the reaction of 2-arylquinazolin-4(3H)-ones and elemental sulfur is described. The rhodium-catalyzed C-H activation of 2-arylquinazolinones and cyclization with elemental sulfur via one-step formation C-S/N-S bonds to give the corresponding 7H-benzo[4,5]isothiazolo[3,2-b]quinazolinones in good to high yields with good functional group tolerance.

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Lurasidone in schizophrenia in adolescents: a profile of its use

Cited by 2 publications

References 13 publications

Aminothiolation of 2-(2-bromophenyl)quinazolinones with elemental sulfur to access 7H-benzo[4,5]isothiazolo[3,2-b]quinazolinones through C–S/S–N bond formation under metal-free condition

Aminothiolation of 2-(2-bromophenyl)quinazolinones with elemental sulfur to access 7H-benzo[4,5]isothiazolo[3,2-b]quinazolinones through C–S/S–N bond formation under metal-free condition

Rhodium-Catalyzed C–H Activation of 2-Arylquinazolinones and Cyclization with Elemental Sulfur via C–S/S–N Bond Formation to Access 7H-Benzo[4,5]isothiazolo[3,2-b]quinazolinones

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