Luteal-phase support in assisted reproductive technology: An ongoing challenge

Dashti, Saeideh; Eftekhar, Maryam

doi:10.18502/ijrm.v19i9.9708

Cited by 14 publications

(8 citation statements)

References 81 publications

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“…Ovulation, implantation, and luteal phase support, which are required for the continuation of pregnancy, are orchestrated by progesterone. In addition to its role in supporting the luteal phase and assisted reproductive technology, progesterone also plays a role in the treatment of TA, as well as in preventing recurrent miscarriage and preterm labor (11,12). By facilitating implantation in early pregnancy, progesterone regulates the mother's immune responses and reduces uterine contractions, helping maintain the fetus (1).…”

Section: Discussionmentioning

confidence: 99%

Micronized Progesterone or Dydrogesterone? A Comparative Study on the Effects of Two Forms of Progesterone on Pregnancy Outcomes After Threatened Abortion

Ansari,

Hajiseid Javadi,

Pakniat

et al. 2023

Iran J Pharm Res

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Background: A significant number of pregnancies are at risk of threatened abortion (TA). Different types of progesterone are used to treat TA. Objectives: In this study, the effects of 2 forms of progesterone on the continuation of pregnancy and TA-caused pregnancy outcomes were compared. Methods: A total of 190 women with a gestational age of 6 - 13 weeks presenting with uterine bleeding, closed cervix, and absence of fetal heart rate diagnosed by vaginal examination and ultrasound were allocated into 2 groups and treated with either (D) dydrogesterone (10 mg twice a day) or (M) micronized progesterone (200 mg, twice a day) for beyond 2 weeks after the cessation of uterine bleeding to ensure that bleeding would not recur. The participants were followed up and received prenatal care until the end of pregnancy. The outcomes of pregnancy were recorded and compared between the 2 groups. Results: The incidence of preeclampsia, gestational diabetes, cesarean section, intrauterine fetal death (IUFD), placenta previa, and abortion was not significantly different between the 2 groups. However, the prevalence of preterm labor and low birth weight (LBW) was significantly lower in M-treated women (P < 0.001 and P = 0.007, respectively). The baby’s weight and gestational age at delivery were significantly higher in the M group than in the D group (P < 0.001). No serious drug side effects were observed in the 2 groups throughout the study. Conclusions: The results of this study showed that the incidence of preterm labor and LBW was significantly lower in the patients treated with micronized progesterone than in patients treated with dydrogesterone; however, the prevalence of preeclampsia, gestational diabetes, cesarean section, IUFD, and abortion was not significantly different between the 2 groups.

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Section: Discussionmentioning

confidence: 99%

Micronized Progesterone or Dydrogesterone? A Comparative Study on the Effects of Two Forms of Progesterone on Pregnancy Outcomes After Threatened Abortion

Ansari,

Hajiseid Javadi,

Pakniat

et al. 2023

Iran J Pharm Res

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“…In artificial cycles, this entails supplementation with exogenous estrogen to cause endometrial proliferation followed by progesterone to induce secretory changes and provide luteal phase support, a function normally performed by the corpus luteum in natural cycles. Progesterone promotes uterine quiescence as well as increases endometrial vascularity and promotes endometrial receptivity, facilitating implantation, among other functions [19] . In fact, progesterone is so important for implantation that insufficient progesterone levels for example in patients with luteal phase deficiency, can result in infertility and pregnancy loss [20] .…”

Section: Progesterone Supplementationmentioning

confidence: 99%

Factors affecting implantation: What really matters?

Mouhanna,

DeCherney

2024

Global Reproductive Health

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Factors affecting embryo implantation, particularly in assisted reproductive technology, remain controversial and poorly understood. Better understanding and optimization of the process of implantation in assisted reproductive technology is important to improving live birth rate and pregnancy outcomes. In this literature review, we examine the key factors involved in implantation and elaborate on current practice, emerging data, and gaps in knowledge.

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“…The luteal phase is the second half of the menstrual cycle, and these medications help maintain a favourable hormonal environment for pregnancy. This phase support may include progesterone supplements and other medications to support the uterine lining, ultimately enhancing the chances of successful embryo implantation and a healthy pregnancy [ 10 ].…”

Section: Reviewmentioning

confidence: 99%

Navigating Fertility Challenges: A Comprehensive Review of Microsurgery for Fallopian Tubal Re-canalization in the Era of In Vitro Fertilization (IVF)

Sethi,

Agrawal,

Dewani

et al. 2024

Cureus

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The journey of addressing fertility challenges, especially in the context of fallopian tubal issues, has witnessed remarkable advancements. This comprehensive review delves into microsurgery for fallopian tubal re-canalization within the era of in vitro fertilization (IVF). The review begins by providing the historical backdrop, tracing the evolution of this surgical technique, and highlighting the transformative impact of microsurgical methods and instrumentation on its precision and outcomes. Microsurgery for fallopian tubal re-canalization is characterized by a range of patient-specific considerations, diagnostic modalities, and factors influencing the choice between re-canalization and IVF. Microsurgical techniques are elaborated upon, showcasing the importance of laparoscopy and hysteroscopy, which not only diagnose but also treat tubal and uterine conditions. The review delves into the pivotal elements that steer the decision-making process, including patient preferences, medical necessity, ethical and religious considerations, financial constraints, and clinical evaluation. Furthermore, the intricate complications and risks associated with tubal re-canalization, both intraoperative and postoperative, are elucidated. Insights into recent advances in microsurgery, emerging research, and promising future directions set the stage for innovative and effective solutions. Recognizing the significance of patient counseling, shared decision-making, ethical considerations, and informed consent, the review underlines the critical role of healthcare providers in guiding individuals and couples through the complexities of fertility treatment choices. Finally, the conclusion synthesizes the key findings, implications for clinical practice, and future research directions, emphasizing the importance of tailored and patient-centered approaches to address fertility challenges in the modern era.

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Luteal-phase support in assisted reproductive technology: An ongoing challenge

Cited by 14 publications

References 81 publications

Micronized Progesterone or Dydrogesterone? A Comparative Study on the Effects of Two Forms of Progesterone on Pregnancy Outcomes After Threatened Abortion

Micronized Progesterone or Dydrogesterone? A Comparative Study on the Effects of Two Forms of Progesterone on Pregnancy Outcomes After Threatened Abortion

Factors affecting implantation: What really matters?

Navigating Fertility Challenges: A Comprehensive Review of Microsurgery for Fallopian Tubal Re-canalization in the Era of In Vitro Fertilization (IVF)

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