Lutein and Zeaxanthin Supplementation and Association With Visual Function in Age-Related Macular Degeneration

Liu, Rong; Wang, Tian; Bao, Zhang; Li, Qin; Wu, Chunrong; Liu, Qingshan; Ma, Le

doi:10.1167/iovs.14-15553

Cited by 100 publications

(114 citation statements)

References 43 publications

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“…Consistent with data generated for visual function, higher macular pigment levels have been linked to improved critical licker fusion frequency [28][29][30][31], higher concentrations in the visual cortex [53], and improvements in electroretinography responses [32,33]. Bovier et al found moderate but statistically signiicant improvements in both MPOD and cognitive function with lutein and zeaxanthin supplementation of young, healthy individuals considered to be at peak cognitive eiciency [34].…”

Section: Neural Processingmentioning

confidence: 60%

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Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Rai¹,

Rai²

2017

Functional Food - Improve Health Through Adequate Food

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The identiication of bioactive food components and understanding their role as adjunct therapeutic agents in disease management and prevention has become a signiicant area of research. Accumulating evidence suggests a link between certain bioactive food components and health outcomes, for example, lutein and zeaxanthin for visual performance and delaying age-related macular degeneration, probiotics for gastrointestinal outcomes related to irritable bowel syndrome or prebiotics for its potential programming of the microbiome in early life to inluence later life outcomes.. This rapidly developing science has triggered discussions to determine if public health recommendations can be made on bioactive foods. However, regulatory guidance is necessary to guide the development the science, it's consideration for public health policy and the communication thereof to both healthcare professionals and consumers. This chapter will focus on the clinical and basic science supporting a role for lutein and pre-and probiotics in modulating several aspects of human health, including the gut microbiome through the human lifecycle. Opportunities to translate the science to consumers in a meaningful and accurate way will also be highlighted along with the regulatory landscape to shape the testing, communication and commercialization of these bioactives.

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Section: Neural Processingmentioning

confidence: 60%

“…A stronger efect was noted for studies using higher doses of supplements. Interestingly, a linear association of MPOD and an increase in visual acuity was also measured [53].…”

Section: Age-related Macular Degeneration (Amd)mentioning

confidence: 83%

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Rai¹,

Rai²

2017

Functional Food - Improve Health Through Adequate Food

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“…Namely, MP acts as a natural blue light filter that protects the eye from oxidative damage (Snodderly, 1995). It is also capable of enhancing contrast by adding luminance contrast information to an edge (Liu et al, 2015;Renzi and Hammond, 2010a). It has been related to visual performance and temporal vision (Renzi and Hammond, 2010b) and it is strongly related to improvements in glare disability and photo stress recovery (Stringham and Hammond, 2007).…”

Section: What Is the Function Of Carotenoids In The Eye?mentioning

confidence: 99%

“…Some epidemiological studies suggest that higher consumption of lutein and zeaxanthin is associated with lower risk of AMD (Whitehead et al, 2006). A recent meta-analysis including 8 randomized clinical trials involving 1176 AMD patients concluded that lutein and zeaxanthin supplementation was a safe strategy to improve visual performance of AMD patients (Liu et al, 2015). In fact, the study by Ma et al (2012) showed that electroretinogram responses increased after lutein supplementation alone or lutein + zeaxanthin supplementation for up to 6 or 12 months in early AMD patients.…”

Section: What Is the Function Of Carotenoids In The Eye?mentioning

confidence: 99%

Why lutein is important for the eye and the brain

Ramírez

2015

OCL

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-Lutein and zeaxanthin are carotenoids that accumulate in the macula. The macula is a yellow spot near the center of the retina that is responsible of high resolution vision. Macular pigment acts as a natural blue light filter and protects the eye from damage. Macular pigment optical density (MPOD) increases with lutein administration and is related to visual function and to the prevention of age-related macular degeneration. MOPD can be measured noninvasively and has been related to better cognitive performance. Moreover, compositional analyses of centenarian brains have shown that lutein is the main carotenoid in the brain although not in plasma, indicating a preferential accumulation in neural tissues, and that carotenoids status is correlated with some functional outcomes. Carotenoids are present in human milk with higher concentration in colostrum than in transitional and mature milk. Formula fed-infants have less plasma lutein concentration than breast fed infants. Analyses of brain from infants who died during the first year of life showed that lutein is also the predominant carotenoid of brain. Studies in non-human primates revealed that carotenoids are determinant in the formation of the retinal epithelia. In vitro studies showed that lutein stimulates the differentiation of human stem cells to neural progenitor cells. All this findings together, mostly the presence of lutein in breast milk, plasma concentration in breast-fed infants vs. formula fed infants, preferential accumulation in the brain and evidences of influence on the retina and the functionality of the brain signal the importance of the role of lutein and zeaxanthin on visual maturation and brain development.Keywords: Lutein / zeaxanthin / brain / infant / nutrition Résumé -Importance de la lutéine pour l'oeil et le cerveau. La lutéine et la zéaxanthine sont des caroténoïdes qui s'accumulent dans la macula. La macula est une tache jaune, située près du centre de la rétine, qui est responsable de la vision fine. Le pigment maculaire agit comme un filtre naturel de la lumière bleue nocive et protège l'oeil contre d'éventuels dommages. La densité optique du pigment maculaire (ou MPOD, acronyme de Macular pigment optical density) augmente avec l'administration de lutéine et est liée à la qualité de la fonction visuelle et à la prévention de la dégénérescence maculaire liée à l'âge. La MOPD peut être mesurée de manière non invasive et a été associée à de meilleures performances cognitives. En outre, les analyses de composition de cerveaux de centenaires ont montré que la lutéine est le caroténoïde principal du cerveau mais pas du plasma, ce qui indique une accumulation préférentielle dans les tissus neuronaux et que le statut en caroténoïdes est corrélé avec quelques données fonctionnelles. Les caroténoïdes sont présents dans le lait maternel avec une concentration plus élevée dans le colostrum que dans lait de transition ou mature. Les enfants nourris avec des formules infantiles (végétales) présentent des diminutions de concentrations...

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“…Studies have shown that macular carotenoid supplementation provides myriad visual health benefits, including improved visual acuity, glare recovery, and contrast sensitivity function [11], along with increasing both neural processing speed and efficiency of visual signals [12]. Furthermore, macular carotenoid supplementation has been linked to improved cognitive function [13] and reduced cortisol levels.…”

Section: Introductionmentioning

confidence: 99%

Restoration of Central Macular Pigment Dip with Dietary RR Zeaxanthin Supplementation in Patients with AMD

Richer¹

2017

AOVS

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Objective: Low macular pigment optical density (MPOD) is a major risk factor for age-related macular degeneration (AMD). This paper investigates the impact of 8 mg dietary RR zeaxanthin (Z) supplementation on MPOD distribution and the associated effect on macular scotomas in patients with a central foveal dip in their macular pigment spatial profile.Methods: This is a retrospective review of The Zeaxanthin and Visual Function RCT (FDA IND 78, 973) with respect to the relation between low levels of MPOD and increased risk of age-related macular degeneration (AMD). We retrospectively examine the effect of daily supplementation of 8 mg of dietary Z on n=4 patients having a baseline central foveal dip in their MPOD distribution. The testing modalities used were a 7⁰ 3D specular reflectance and the associated kinetic 20° macular visual fields.Results: Over a 12-month period, all four patients showed a progressive increase in central peak restoration with related kinetic and/or Amsler grid visual field data. Conclusion:The initial results demonstrate marked improvement in macular pigment architecture and overall visual function after 12 months of Z supplementation. These results warrant a prospective clinical trial with a larger number of subjects to investigate the role of Z in central dip amelioration.

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Lutein and Zeaxanthin Supplementation and Association With Visual Function in Age-Related Macular Degeneration

Abstract: Lutein and zeaxanthin supplementation is a safe strategy for improving visual performance of AMD patients, which mainly showed in a dose-response relationship.

Cited by 100 publications

References 43 publications

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Why lutein is important for the eye and the brain

Restoration of Central Macular Pigment Dip with Dietary RR Zeaxanthin Supplementation in Patients with AMD

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