Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study

Dani, Carlo; Lori, Ilaria; Favelli, Federica; Frosini, Saverio; Messner, Hubert; Wanker, Petra; Marini, Sergio De; Oretti, Chiara; Boldrini, Antonio; Ciantelli, Massimiliano; Bragetti, P; Germini, Cristiana

doi:10.3109/14767058.2011.629252

Cited by 50 publications

(62 citation statements)

References 30 publications

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“…[63][64][65] However, clinical trials that tested the efficacy of various antioxidants, including vitamin E, N-acetylcysteine, and lutein, have been inconclusive or have shown unacceptable side effects in infants with retinopathy of prematurity. 66,67 Studies of vitamin E supplementation in preterm infants were stopped because of sepsis and necrotizing enterocolitis, but a later meta-analysis of some studies suggested that vitamin E supplementation was associated with reduced stage 3 retinopathy of prematurity. 68 Thus, although it appears that oxidative stress promotes some aspects of severe retinopathy of prematurity, broad inhibition by antioxidants may not be safe.…”

Section: Antioxidantsmentioning

confidence: 99%

Mechanisms and Management of Retinopathy of Prematurity

Rao

Dlouhy

2013

N Engl J Med

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Section: Antioxidantsmentioning

confidence: 99%

Mechanisms and Management of Retinopathy of Prematurity

Rao

Dlouhy

2013

N Engl J Med

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“…To date, four RCTs have investigated the relationship between xanthophylls and ROP [17,[143][144][145]. All studies included preterm infants <33 weeks gestational age.…”

Section: Macular Xanthophyll Lutein/zeaxanthin and Retinopathy Of Prementioning

confidence: 99%

Role of macular xanthophylls in prevention of common neovascular retinopathies: Retinopathy of prematurity and diabetic retinopathy

Gong

Rubin

2015

Archives of Biochemistry and Biophysics

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“…Capeding et al addressed safety, tolerance and growth (Capeding et al, 2010). There have been three papers suggesting a potential influence of lutein supplementation on the prevention on the retinopathy of prematurity (Dani et al, 2012;Manzoni et al, 2013;Romagnoli et al, 2011). The first one did not showed any effect of lutein/zeaxanthin supplementation.…”

Section: Is There a Translation To Functionality?mentioning

confidence: 99%

Why lutein is important for the eye and the brain

Ramírez

2015

OCL

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-Lutein and zeaxanthin are carotenoids that accumulate in the macula. The macula is a yellow spot near the center of the retina that is responsible of high resolution vision. Macular pigment acts as a natural blue light filter and protects the eye from damage. Macular pigment optical density (MPOD) increases with lutein administration and is related to visual function and to the prevention of age-related macular degeneration. MOPD can be measured noninvasively and has been related to better cognitive performance. Moreover, compositional analyses of centenarian brains have shown that lutein is the main carotenoid in the brain although not in plasma, indicating a preferential accumulation in neural tissues, and that carotenoids status is correlated with some functional outcomes. Carotenoids are present in human milk with higher concentration in colostrum than in transitional and mature milk. Formula fed-infants have less plasma lutein concentration than breast fed infants. Analyses of brain from infants who died during the first year of life showed that lutein is also the predominant carotenoid of brain. Studies in non-human primates revealed that carotenoids are determinant in the formation of the retinal epithelia. In vitro studies showed that lutein stimulates the differentiation of human stem cells to neural progenitor cells. All this findings together, mostly the presence of lutein in breast milk, plasma concentration in breast-fed infants vs. formula fed infants, preferential accumulation in the brain and evidences of influence on the retina and the functionality of the brain signal the importance of the role of lutein and zeaxanthin on visual maturation and brain development.Keywords: Lutein / zeaxanthin / brain / infant / nutrition Résumé -Importance de la lutéine pour l'oeil et le cerveau. La lutéine et la zéaxanthine sont des caroténoïdes qui s'accumulent dans la macula. La macula est une tache jaune, située près du centre de la rétine, qui est responsable de la vision fine. Le pigment maculaire agit comme un filtre naturel de la lumière bleue nocive et protège l'oeil contre d'éventuels dommages. La densité optique du pigment maculaire (ou MPOD, acronyme de Macular pigment optical density) augmente avec l'administration de lutéine et est liée à la qualité de la fonction visuelle et à la prévention de la dégénérescence maculaire liée à l'âge. La MOPD peut être mesurée de manière non invasive et a été associée à de meilleures performances cognitives. En outre, les analyses de composition de cerveaux de centenaires ont montré que la lutéine est le caroténoïde principal du cerveau mais pas du plasma, ce qui indique une accumulation préférentielle dans les tissus neuronaux et que le statut en caroténoïdes est corrélé avec quelques données fonctionnelles. Les caroténoïdes sont présents dans le lait maternel avec une concentration plus élevée dans le colostrum que dans lait de transition ou mature. Les enfants nourris avec des formules infantiles (végétales) présentent des diminutions de concentrations...

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Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study

Abstract: L/Z supplementation was ineffective in preventing ROP in preterm infants and did not affect the outcome at discharge of our patients.

Cited by 50 publications

References 30 publications

Mechanisms and Management of Retinopathy of Prematurity

Mechanisms and Management of Retinopathy of Prematurity

Role of macular xanthophylls in prevention of common neovascular retinopathies: Retinopathy of prematurity and diabetic retinopathy

Why lutein is important for the eye and the brain

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