Lutein exerts anti-inflammatory effects in patients with coronary artery disease

Chung, Rosanna W. S.; Leanderson, Per; Lundberg, Anna; Jonasson, Lena

doi:10.1016/j.atherosclerosis.2017.05.008

Cited by 112 publications

(67 citation statements)

References 42 publications

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“…Although the plasma level of lutein did not differ significantly between COPD and control subjects, it was negatively associated with IL-6 (Figure 2(a)). It has recently been shown that lutein could act anti-inflammatory and play a role in chronic disorders such as coronary artery disease [24]. In that study, the plasma level of lutein was inversely associated with IL-6 in serum from patients with coronary artery disease and lutein did also attenuate the release of inflammatory cytokines by lipopolysaccharide-treated peripheral blood mononuclear cells ex vivo .…”

Section: Discussionmentioning

confidence: 84%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective: To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects. Methods: Sixty-six Caucasians with advanced COPD (28 with LTOT) and 47 control subjects were included. Questionnaires about general health, lifestyle, and dietary habits were answered. Lung function tests and blood sampling were performed. Results: COPD subjects (±LTOT) did not demonstrate increased oxidative damage, assessed by protein carbonylation (PC), while levels of soluble transferrin receptors (sTfRs) were slightly elevated. Soluble TfRs, which is inversely related to Fe status, was negatively associated with PC. Levels of carotenoids, total and β-cryptoxanthin, α- and β-carotenes, were significantly lower in COPD subjects, and their diet contained significantly less fruits and vegetables. Lutein correlated inversely with IL-6, lycopene correlated inversely with SAT, while β-carotene was positively associated with a Mediterranean-like diet. Conclusions: Fe could favor oxidative stress in COPD patients, suggesting a cautious use of Fe prescription to these patients. COPD subjects ate a less healthy diet than control subjects did and would, therefore, benefit by dietary counseling. COPD patients with hypoxemia are probably in particular need of a lycopene-enriched diet.

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Section: Discussionmentioning

confidence: 84%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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“…It was found that zeaxanthin significantly inhibits diabetes-induced retinal oxidative damage and elevations in VEGF and its adhesion molecule, abnormalities which are commonly associated with the pathogenesis of diabetic retinopathy (19) . Clinical findings have highlighted the inverse association between lutein and IL-6 in coronary artery disease patients (97) . A recent novel RCT, the Diabetes Visual Function Supplement Study (DiVFuSS) (31) , explored the effects of a nutritional supplement (which included lutein and zeaxanthin) on patients with type 1 and type 2 diabetes, and suggested that the preparation used mitigated the damaging effects of systemic inflammation on ocular function, and that these effects may have been mediated by enhancements in MPOD.…”

Section: Inflammation and Diabetesmentioning

confidence: 99%

A review of the putative causal mechanisms associated with lower macular pigment in diabetes mellitus

et al. 2019

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Macular pigment (MP) confers potent antioxidant and anti-inflammatory effects at the macula, and may therefore protect retinal tissue from the oxidative stress and inflammation associated with ocular disease and ageing. There is a body of evidence implicating oxidative damage and inflammation as underlying pathological processes in diabetic retinopathy. MP has therefore become a focus of research in diabetes, with recent evidence suggesting that individuals with diabetes, particularly type 2 diabetes, have lower MP relative to healthy controls. The present review explores the currently available evidence to illuminate the metabolic perturbations that may possibly be involved in MP's depletion. Metabolic co-morbidities commonly associated with type 2 diabetes, such as overweight/obesity, dyslipidaemia, hyperglycaemia and insulin resistance, may have related and independent relationships with MP. Increased adiposity and dyslipidaemia may adversely affect MP by compromising the availability, transport and assimilation of these dietary carotenoids in the retina. Furthermore, carotenoid intake may be compromised by the dietary deficiencies characteristic of type 2 diabetes, thereby further compromising redox homeostasis. Candidate causal mechanisms to explain the lower MP levels reported in diabetes include increased oxidative stress, inflammation, hyperglycaemia, insulin resistance, overweight/ obesity and dyslipidaemia; factors that may negatively affect redox status, and the availability, transport and stabilisation of carotenoids in the retina. Further study in diabetic populations is warranted to fully elucidate these relationships.

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“…Many studies describe the benefits of lutein and its isomer "zeaxanthin" via oral administration or after topical application. They are able to reduce the risk of ocular diseases ( Bartlett and Eperjesi 2004, Moeller et al 2008, Beatty et al 2013, Huang et al 2015 and provide protective effect against cardiovascular diseases, stroke and cholesterol (Asplund 2002, Hak et al 2004, Zou et al 2011, Chung et al 2017, Kishimoto et al 2017. Oral treatment with the carotenoids lutein and zeaxanthin leads to a carotenoid deposition in the skin (Lee et al 2004, Wu et al 2002.…”

Section: The Effects Of Lutein and Zeaxanthin On Healthmentioning

confidence: 99%

Untitled

Okur

2019

KSEJ

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Carotenoids can be grouped into several subclassifications, with the most familiar being the provitamin A carotenoids (those that can be converted to vitamin A in the human body) and the non-provitamin A carotenoids (those that cannot be converted to vitamin A in the human body). Lutein and zeaxanthin belong to the subclass of non-provitamin A carotenoids known as the xanthophylls. Xanthophylls are also different from other

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Lutein exerts anti-inflammatory effects in patients with coronary artery disease

Cited by 112 publications

References 42 publications

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

A review of the putative causal mechanisms associated with lower macular pigment in diabetes mellitus

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