Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis

Kavalappa, Yogendra Prasad; Gopal, Sowmya Shree; Ponesakki, Ganesan

doi:10.1002/jcp.29961

Cited by 40 publications

(27 citation statements)

References 58 publications

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“…epNPs have been reported to contain various biologically active molecules [13,14,16,17]. Lutein and zeaxanthin, the xanthophylls present in corn [28,29], are known to exhibit antitumor effects through regulation of cell cycle or cell apoptosis [42][43][44]. It has been reported that zeaxanthin induced cell cycle arrest at the G2/M phase and apoptosis through the ROS-mediated MAPK, AKT, NF-κB, and STAT3 signaling pathways [43].…”

Section: Discussionmentioning

confidence: 99%

“…Lutein and zeaxanthin, the xanthophylls present in corn [28,29], are known to exhibit antitumor effects through regulation of cell cycle or cell apoptosis [42][43][44]. It has been reported that zeaxanthin induced cell cycle arrest at the G2/M phase and apoptosis through the ROS-mediated MAPK, AKT, NF-κB, and STAT3 signaling pathways [43]. High-performance liquid chromatography analysis in the present study con rmed the presence of lutein and zeaxanthin in cNPs (data not shown).…”

Section: Discussionmentioning

confidence: 99%

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Development of Corn-Derived Nanoparticles as Mass-Producible Bionanoparticles with Anticancer Activity

Sasaki¹,

Kusamori²,

Nishikawa³

2021

Preprint

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Recent studies have shown that plant-derived nanoparticles (NPs) contain biologically active molecules and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as a material for plant-derived NPs as corn is inexpensive to grow and is mass-produced globally, and these characteristics are similar to those of plant-derived NPs, which are easy to prepare and can be produced at high yields and low costs. Super sweet corn was homogenized in water to obtain corn juice, which was then centrifuged, filtered through a 0.45 µm-pore size syringe filter, and ultracentrifuged to obtain corn-derived NPs (cNPs). cNPs obtained were approximately 80 nm in diameter and negatively charged (−17 mV). cNPs were taken up by various types of cells, including colon26 tumor cells and RAW264.7 macrophage-like cells, with selective reduction of the proliferation of colon26 cells. Moreover, cNPs induced tumor necrosis factor-α release from RAW264.7 cells. cNPs and RAW264.7 in combination significantly suppressed the proliferation of colon26/fluc cells. Daily intratumoral injections of cNPs significantly suppressed the growth of subcutaneous colon26 tumors in mice, with no significant body weight loss. These results indicate excellent anti-tumor activity of cNPs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of Corn-Derived Nanoparticles as Mass-Producible Bionanoparticles with Anticancer Activity

Sasaki¹,

Kusamori²,

Nishikawa³

2021

Preprint

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“…The effects of lutein against prostate, breast, and cancer cells have been reported elsewhere [96,97]. It has been shown that lutein could suppress the phosphorylation of protein kinase B, ERK 1/2, and NFkB in breast cancer cells [98]. Lutein has been shown to inhibit breast cancer cells and increase the efficacy of a chemotherapeutic [99].…”

Section: Luteinmentioning

confidence: 98%

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cancer

2021

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Green-colored foods, such as broccoli, sprouts, soybean, and green leafy vegetables are considered one of the representative healthy foods for containing various functional ingredients that can combat chronic diseases, including diabetes, obesity, and cancer. Herein, we reviewed the anti-cancer activities and the underlying mechanisms of some important bioactive compounds, such as sulforaphane, catechins, chlorophyll, isoflavone, indole dervatives, and lutein, present in green-colored foods. In vivo and clinical studies suggest that sulforaphane, a sulfur-containing compound found in cruciferous vegetables, can ameliorate prostate and breast cancer symptoms by arresting cell-cycle progression and modulating Ki67 and HDAC expression. A green tea compound, known as epigallocatechin-3-gallate (EGCG), has shown remarkable anti-cancer effects against prostate cancer and lung adenocarcinoma in human trials through its antioxidative defense and immunomodulatory functions. Chlorophyll, a natural pigment found in all green plants, can regulate multiple cancer-related genes, including cyclin D1, CYP1A, CYP1B1, and p53. Epidemiological studies indicate that chlorophyll can substantially reduce aflatoxin level and can mitigate colon cancer in human subjects. Remarkably, the consumption of soy isoflavone has been found to be associated with the lower incidence and mortality of breast and prostate cancers in East Asia and in Canada. In vivo and in vitro data point out that isoflavone has modulatory effects on estrogen and androgen signaling pathways and the expression of MAPK, NfκB, Bcl-2, and PI3K/AKT in different cancer models. Other green food bioactive compounds, such as indole derivatives and lutein, also exhibited suppressing effects in rodent models of lung, liver, stomach, cervical, and prostate cancers. In addition, some micronutrients, such as folate, riboflavin, retinoic acid, and vitamin D3 present in green foods, also showed potential cancer suppressing effects. Taken together, these data suggest potential chemopreventive functions of the bioactive compounds from green-colored foods. This paper could be beneficial for further research on the anti-carcinogenic effects of green-colored food-derived compounds, in order to develop green chemotherapeutics for cancers.

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“…In this regard, LUT inhibited cell growth and induced apoptosis in two breast cancer lines, the non-invasive MCF-7 and invasive MDA-MB-231 cells. The mechanisms underlying these effects were associated with an inhibition of the transcription factor Nrf2 and its target genes SOD-2 and HO-1, as well as a down-regulation of cell survival markers such as pAkt, pERK, and NF-κB [407]. Other mechanisms involved in the anti-breast cancer effects of this carotenoid include inhibition of glycolysis [408], suppression of cell cycle progression, stimulation of p53 signaling, and an increase in cellular heat shock protein 60 expression [409].…”

Section: In Vitro Studiesmentioning

confidence: 99%

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis

Cited by 40 publications

References 58 publications

Development of Corn-Derived Nanoparticles as Mass-Producible Bionanoparticles with Anticancer Activity

Development of Corn-Derived Nanoparticles as Mass-Producible Bionanoparticles with Anticancer Activity

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cancer

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

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