Lutein-loaded chitosan/alginate-coated Fe3O4 nanoparticles as effective targeted carriers for breast cancer treatment

Bulatao, Bryan Paul I.; Nalinratana, Nonthaneth; Jantaratana, Pongsakorn; Vajragupta, Opa; Rojsitthisak, Pornchai; Rojsitthisak, Pornchai

doi:10.1016/j.ijbiomac.2023.124673

Cited by 22 publications

(4 citation statements)

References 87 publications

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“… The procedure for synthesizing CS/Alg-IONPs is adapted from previous research [2] . The quantities of Alg, CS, FeCl 2 ·4H 2 O, and FeCl 3 ·6H 2 O have been optimized to obtain desirable characteristics of the polymer-coated IONPs.…”

Section: Methodsmentioning

confidence: 99%

Design and development of a magnetic field-enabled platform for delivering polymer-coated iron oxide nanoparticles to breast cancer cells

Bulatao¹,

Nalinratana²,

Jantaratana³

et al. 2023

MethodsX

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Section: Methodsmentioning

confidence: 99%

Design and development of a magnetic field-enabled platform for delivering polymer-coated iron oxide nanoparticles to breast cancer cells

Bulatao¹,

Nalinratana²,

Jantaratana³

et al. 2023

MethodsX

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“…This magnetic guidance enhances the accumulation of NPs in tumor sites and allows for controlled drug release and precise localization when combined with light and heat. 145 Hu 146 used superparamagnetism Fe 3 O 4 NPs as the carrier to prepare photomagnetic dual-sensitive BU liposomes (BF-Fe 3 O 4 -L). Application of a magnetic field increased drug uptake by 1.6 times compared to conditions without the magnetic field.…”

Section: Stimuli-responsive Targeted Drug Delivery Systemsmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

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Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

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“…β-cryptoxanthin has shown its potential in various cancers, including stomach cancer ( Sengngam et al., 2022 ), hepatocellular carcinoma ( Lim et al., 2020 ), lung cancer ( Iskandar et al., 2016 ), and colon cancer ( San Millan et al., 2015 ). Lutein was reportedly having strong anticancer potential against breast cancer ( Bulatao et al., 2023 ), non-small cell lung cancer ( Zhang et al., 2023 ), pancreatic cancer ( Han and Song, 2022 ), and gastric cancer ( Eom et al., 2023 ). Zeaxanthin has anticancer potential against melanoma ( Cenariu et al., 2021 ), colorectal cancer ( Kim et al., 2019 ), dermal fibroblasts ( Wu et al., 2010 ), and gastric cancer ( Abnet et al., 2003 ).…”

Section: Phytochemicals Present In O Ficus-indica ...mentioning

confidence: 99%

Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives

Wang,

Rani,

Jakhar

et al. 2023

Front. Plant Sci.

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Cancer is a leading cause of mortality worldwide, and conventional cancer therapies such as chemotherapy and radiotherapy often result in undesirable and adverse effects. Natural products have emerged as a promising alternative for cancer treatment, with comparatively fewer side effects reported. Opuntia ficus-indica (L.) Mill., a member of the Cactaceae family, contains a diverse array of phytochemicals, including flavonoids, polyphenols, betalains, and tannins, which have been shown to exhibit potent anticancer properties. Various parts of the Opuntia plant, including the fruits, stems/cladodes, and roots, have demonstrated cytotoxic effects against malignant cell lines in numerous studies. This review comprehensively summarizes the anticancer attributes of the phytochemicals found in Opuntia ficus-indica (L.) Mill., highlighting their potential as natural cancer prevention and treatment agents. Bibliometric metric analysis of PubMed and Scopus-retrieved data using VOSviewer as well as QDA analysis provide further insights and niche to be explored. Most anticancer studies on Opuntia ficus-indica and its purified metabolites are related to colorectal/colon cancer, followed by melanoma and breast cancer. Very little attention has been paid to leukemia, thyroid, endometrial, liver, and prostate cancer, and it could be considered an opportunity for researchers to explore O. ficus-indica and its metabolites against these cancers. The most notable mechanisms expressed and validated in those studies are apoptosis, cell cycle arrest (G0/G1 and G2/M), Bcl-2 modulation, antiproliferative, oxidative stress-mediated mechanisms, and cytochrome c. We have also observed that cladodes and fruits of O. ficus-indica have been more studied than other plant parts, which again opens the opportunity for the researchers to explore. Further, cell line-based studies dominated, and very few studies were related to animal-based experiments. The Zebrafish model is another platform to explore. However, it seems like more in-depth studies are required to ascertain clinical utility of this biosustainable resource O. ficus-indica.

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Lutein-loaded chitosan/alginate-coated Fe3O4 nanoparticles as effective targeted carriers for breast cancer treatment

Cited by 22 publications

References 87 publications

Design and development of a magnetic field-enabled platform for delivering polymer-coated iron oxide nanoparticles to breast cancer cells

Design and development of a magnetic field-enabled platform for delivering polymer-coated iron oxide nanoparticles to breast cancer cells

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives

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