2024
DOI: 10.21203/rs.3.rs-4641525/v1
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Lutein protection against doxorubicin-induced liver damage in male Wistar rat is associated with inhibition of oxido-inflammatory stress and modulation of Beclin-1/mTOR activities

Jerome Ndudi Asiwe,
Godwin D. Yovwi,
Mercy Oluwalani Alawode
et al.

Abstract: A wide range of clinical applications are reported for doxorubicin (DOX), yet both people and research animals experience substantial tissue damage. However, the protective mechanism of lutein, a natural carotenoid against doxorubicin associated liver toxicity has not been fully studied. Therefore, the aim of this study is to investigate the protective mechanism of lutein in doxorubicin-induced liver damage. Twenty male Wistar rats were randomly assigned to four groups and treated as follows: Group 1 was admin… Show more

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