Lutein protects against ischemia/reperfusion injury in rat kidneys

Abstract

Ischemia‑reperfusion (I/R) injury has a major impact on renal dysfunction during transplantation. The present study investigated the role of lutein against I/R injury‑induced oxidative stress in rat kidneys. Biochemical analysis and oxidative stress parameters demonstrated that lutein protected the rat kidney significantly from I/R injury. Pretreatment with lutein significantly increased the total antioxidant capacity with a concomitant decline in the total oxidant status. Rats with I/R injury showed a significant increase in oxidative stress. The results revealed significant increases in the levels of lipid peroxidation and protein carbonyl content with concomitant decreases in enzymic and non‑enzymic antioxidants. The activity of these enzymes was reversed and demonstrated a significant increase following lutein pre‑treatment compared with the rats subjected to I/R injury alone. Furthermore, lutein protected the renal tissue from I/R injury by maintaining normal kidney architecture and led to a reduction in the levels of the renal markers urea and creatinine in the serum. These results demonstrated clear evidence that lutein offered a significant protective effect against I/R injury by enhancing antioxidant defense mechanisms.

Honokiol protects against renal ischemia/reperfusion injury via the suppression of oxidative stress, iNOS, inflammation and STAT3 in rats

“…In ischemia, a high level of ATP is decomposed, leading to the accumulation of hypoxanthine, recovery of blood perfusion causes the generation of a substantial number of reactive oxygen free radicals, and peroxy radicals and their degradation products cause tissue damage by lipid peroxidation of mitochondria and lipid membranes (29). In the present study, honokiol treatment depressed serum levels of MDA and MPO, and increased the activities of SOD and CAT in the IRI rats.…”

Lutein protects against ischemia/reperfusion injury in rat skeletal muscle by modulating oxidative stress and inflammation

“…Lutein-induced antiinflammation has been reported against atherosclerosis, UVdamage induced skin-inflammation, LPS inflammation in macrophages [10][11][12] . Further protective role of Lutein against small intestine 13 and kidney 14 ischemic injury has been reported recently. This study examines the role of Lutein against skeletal muscle injury and aims at exploring important mediators involved in oxidative stress and inflammation and aims at determining the potential role of Lutein against skeletal IR injury.…”

Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation

“…Anti-inflammatory effects of lutein in lipopolysaccharide (LPS)-induced inflammation in macrophages and skin inflammation were mediated through downregulating inflammatory proteins and cytokine expression [ 9 , 10 ]. Furthermore, the protective role of lutein against ischemic injury in the small intestine and kidney [ 11 , 12 ] has been reported. Lutein’s protection against paracetamol, carbon tetrachloride and ethanol induced liver damage is mediated through its antioxidant effects [ 13 ].…”