Luteinizing hormone-follicle stimulating hormone ratio as biological predictor of post-partum depression

Pillai, Raji Ramachandran; Sharon, Leena; Premkumar, Nancy; Kattimani, Shivanand; Sagili, Haritha; Rajendiran, Soundravally

doi:10.1016/j.comppsych.2016.09.001

Cited by 15 publications

(10 citation statements)

References 44 publications

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“…We also found that the AUC, specificity, and sensitivity of the ROC curve for CRH/5-HT ratio were 0.92, 0.86, and 0.95 respectively, which was more reliable than using CRH or 5-HT Several researchers reported that other biomarkers, such as adrenocorticotropic hormone, cortisol, prolactin, thyroid-stimulating hormone, and 5-HT, may play an important role in PPD and may be good biomarkers for PPD. [16][17][18][19] However, the accuracy of these biomarkers was not high enough for prediction of PPD. Consequently, it is very necessary to explore a novel biomarker for PPD.…”

Section: Discussionmentioning

confidence: 99%

“…Yim et al 14 reported that the placental CRH at 25 weeks of gestational age is a workable diagnostic tool, although the sensitivity and specificity were moderate. Several researchers reported that other biomarkers, such as adrenocorticotropic hormone, cortisol, prolactin, thyroid‐stimulating hormone, and 5‐HT, may play an important role in PPD and may be good biomarkers for PPD 16–19 . However, the accuracy of these biomarkers was not high enough for prediction of PPD.…”

Section: Discussionmentioning

confidence: 99%

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Predictive value of serum CRH/5‐HT ratio for postpartum depression

Cao

2020

Intl J Gynecology & Obste

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Objective: To analyze the changes in the serum levels of CRH and 5-HT in women with postpartum depression (PPD) and to study the value of the CRH/5-HT ratio for the prediction of PPD. Methods: This prospective study recruited pregnant women from the Fourth Affiliated Hospital, China Medical University between January 2017 and October 2019. Women were considered for inclusion if they had no history, or no current evidence, of a psychiatric disorder. All women were assessed at postpartum day 10 with the Edinburgh Postnatal Depression Scale (EPDS). Blood samples were obtained at 20 weeks of pregnancy and the levels of CRH and 5-HT were determined by radioimmunoassay and ELISA. Associations between EPDS score, the demographic variables, and hormone levels were identified using bivariate logistic regression models. Results: A total of 185 women were included. We found that the serum level of both CRH and 5-HT was significantly correlated with EPDS score; the AUC for CRH was 0.79, and 5-HT was 0.85, which indicated that both CRH and 5-HT are a reliable biomarker for PPD. The AUC, specificity, and sensitivity of CRH/5-HT were 0.92, 0.86, and 0.95, respectively, which were better than those of CRH or 5-HT individually. Conclusions: We believe that the serum CRH/5-HT ratio is an excellent biomarker for the prediction of PPD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predictive value of serum CRH/5‐HT ratio for postpartum depression

Cao

2020

Intl J Gynecology & Obste

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“…Alternately, both may vary in relation to the levels of progesterone, as a significant positive correlation between progesterone and motilin was found in the latter study [88]. These results are of significance given the following observations regarding depression in women: (1) the established associations between depressive symptoms and the late luteal phase of the menstrual cycle, including exacerbations of pre-existing depression as well as phasic symptoms [89,90], (2) increased rates of gastrointestinal symptoms in women with a premenstrual exacerbation of depression [90], (3) evidence that exogenous progesterone analogs can induce depression, particularly in the post-partum period [91] and (4) evidence that reduced LH or elevated follicle-stimulating hormone (FSH) levels may be associated with an increased risk of depression as well as a poorer response to antidepressants in post-partum or post-menopausal women [92,93]. Though a definitive conclusion cannot be drawn from this data, there are possible correlations between the FSH, LH, progesterone and motilin levels which may be of relevance to depression, particularly in women.…”

Section: Neuroendocrine Axis Functioningmentioning

confidence: 99%

Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin

Rajkumar

2021

Life

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Recent research has identified the gut–brain axis as a key mechanistic pathway and potential therapeutic target in depression. In this paper, the potential role of gut hormones as potential treatments or predictors of response in depression is examined, with specific reference to the peptide hormone motilin. This possibility is explored through two methods: (1) a conceptual review of the possible links between motilin and depression, including evidence from animal and human research as well as clinical trials, based on a literature search of three scientific databases, and (2) an analysis of the relationship between a functional polymorphism (rs2281820) of the motilin (MLN) gene and cross-national variations in the prevalence of depression based on allele frequency data after correction for potential confounders. It was observed that (1) there are several plausible mechanisms, including interactions with diet, monoamine, and neuroendocrine pathways, to suggest that motilin may be relevant to the pathophysiology and treatment of depression, and (2) there was a significant correlation between rs2281820 allele frequencies and the prevalence of depression after correcting for multiple confounding factors. These results suggest that further evaluation of the utility of motilin and related gut peptides as markers of antidepressant response is required and that these molecular pathways represent potential future mechanisms for antidepressant drug development.

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“…[7] This has stimulated researchers to investigate speci c biomarkers that can predict and identify PPD objectively like the Leptin level, Brain-Derived Neurotrophic Factor(BDNF), LH:FSH ratio, and oxytocin level. [8][9][10][11] Oxytocin is a peptide hormone synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and released into the bloodstream via the posterior pituitary gland. A large body of research supports the role of oxytocin as a social hormone in humans.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] This places PPD one of the most common and most serious public health problems, since it is a major contributor of the 8 % maternal deaths related to mental health problems.[5] Moreover, infants of PPD mothers are at a great risk of their physical, emotional, cognitive, and interpersonal problems in their later lives.[6]PPD is often underdiagnosed and untreated for many reasons related to maternal underreporting of symptoms, poor awareness of the medical care providers, and limited sensitivity of the available screening tools.[7] This has stimulated researchers to investigate speci c biomarkers that can predict and identify PPD objectively like the Leptin level, Brain-Derived Neurotrophic Factor(BDNF), LH:FSH ratio, and oxytocin level. [8][9][10][11] Oxytocin is a peptide hormone synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and released into the bloodstream via the posterior pituitary gland. A large body of research supports the role of oxytocin as a social hormone in humans.[12] However, the available evidence of the effect of antenatal oxytocin on PPD is not robust enough to be applied clinically as a biologic marker nor as a treatment option.[13] This study aims to investigate the association between serum oxytocin concentration in the third trimester and postpartum depression symptoms in the early postnatal period and whether antenatal oxytocin level is capable of predicting postpartum depression symptoms.…”

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confidence: 99%

The Role of Third Trimester Oxytocin Level in Predicting Postpartum Depression Symptoms among Jordanian Mothers.

Rawashdeh¹,

Alalwani²,

Sindiani³

et al. 2021

Preprint

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Background: About one in five women suffer from postpartum depression, placing it the leading complication during childbirth. Oxytocin has been suggested to play a key role in modulating maternal behaviour and stress-related disorders. However, there is little evidence to support its role in predicting postpartum depression. Our aim is to investigate the relationship between serum oxytocin level in the third trimester and early-onset postpartum depression symptoms and whether oxytocin is capable of predicting postpartum depression symptoms.Methods: A total of 172 healthy pregnant women participated in this cross-sectional descriptive study. The serum oxytocin level was measured between 34 and 37 weeks. A validated Edinburgh Postnatal Depression Scale (EPDS) was used to assess symptoms of depression four to six weeks postpartum. Participants with EPDS scores of 13 or more were considered having depressive symptoms. SPSS version 23 was used for data analysis. Descriptive statistics were provided. Independent sample t-test and Pearson r were used to examine differences in depression scores between selected demographic, psychosocial, and clinical variables. The level of significance for all analyses was set at α=0.05.Results: 8% of participants have scored 13 or above at the EPDS. Pearson r indicated that there was no correlation between EPDS scores and oxytocin level r(170)=0.10, p=0.23. Furthermore, there was no correlation between EPDS scores and oxytocin level among women with a lifetime history of depression, r(43)= - 0.13, p=0.37. Independent t-test has shown that participants with low education, low income, previous history of depression, positive family history of depression, positive family issues and absent emotional family support have scored significantly higher on EPDS scores than their counterparts. The association with a previous lifetime history of depression was noticeable t(170)= - 4.40, p<0.001.Conclusions: There was no relation between late antenatal third trimester serum oxytocin level and early onset postpartum depression symptoms. Third trimester serum oxytocin level alone was not capable of predicting early onset postpartum depression.

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Luteinizing hormone-follicle stimulating hormone ratio as biological predictor of post-partum depression

Cited by 15 publications

References 44 publications

Predictive value of serum CRH/5‐HT ratio for postpartum depression

Predictive value of serum CRH/5‐HT ratio for postpartum depression

Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin

The Role of Third Trimester Oxytocin Level in Predicting Postpartum Depression Symptoms among Jordanian Mothers.

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