Luteinizing hormone-releasing hormone and analogs. Synthesis and biological activity

Blockade of LH–RH induced ovulation in immature rats by LH–RH antiserum

“…LH-RH', synthesized at Ayerst Research Laboratories, Montreal (Immer et al 1974) was dissolved in physiological saline containing 0.5% activated alumina; emulsification in an equal volume of complete Freund's adjuvant resulted in a final peptide concentration of 1 mg/ml. Three mature virgin female New Zealand white rabbits.…”

Ovulation Induction and Antifertility Effects of an Lh-Rh Analogue (Ay-25,205) in Cyclic Rats

“…Potent analogues of this decapeptide have also been synthesized and their potencies compared to that of synthetic LH-RH with respect to hypophysial LH-and FSH-release (Coy & co-authors, 1974;Kastin & co-authors, 1974;Arimura, Vilchez-Martinez & Schally, 1974a; Coy, Coy, Hirotsu & Schally, 1974b) and ovulation-inducing activity in rats (Fujino & co-authors, 1974a, b). A synthetic LH-RH and a few of its analogues have also been synthesized in our laboratories (Immer, Nelson, Revesz, Sestanj & Götz, 1974).…”

Structural Biochemistry XIII: Synthesis of Luteinizing Hormone - Releasing Hormone Modification [ Trp8]- LH - RH

“…This discovery has impressive potential for solving certain medical problems, from overcoming a cause of female sterility to opening new approaches to contraception. Therefore, synthetic efforts directed a t the decapeptide hormone and related substances have been undertaken and presently underlie the major effort in decapeptide chemistry (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). BACKGROUND One facet of the LH-RH potential that seemed particularly attractive was that a suitable modification of this hormone might inhibit certain cancer types, e.g., of the ovary.…”