Luteinizing hormone-releasing hormone rapidly elicits an opening of membrane Ca2+ channels which is suppressed by protein kinase C

Mitchell, Rory; Minaur, Nicola; Johnson, Mark; Ogier, Sally-Ann; Fink, George

doi:10.1042/bst0150139

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Sally-ann Ogler1

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1988

1989

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“…protein kinase C; PMA, phorbol 12-myristate 13-acetate; H7, I -( S-isoquinolinesulphonyl)-2-methylpiperazine hydrochloride. employing the 4'CaL' influx protocol described in detail previously (Mitchell et al, 1986).…”

Section: Sally-ann Oglermentioning

confidence: 99%

Regulation of receptor-operated Ca2+ influx by protein kinase C

Mitchell¹,

Johnson²,

Ogier³

1988

Biochemical Society Transactions

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Section: Sally-ann Oglermentioning

confidence: 99%

Regulation of receptor-operated Ca2+ influx by protein kinase C

Mitchell¹,

Johnson²,

Ogier³

1988

Biochemical Society Transactions

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Regulation of Receptor‐Operated and Depolarization‐Operated Ca²⁺ Influx in Anterior Pituitary Tissue

Mitchell¹,

Johnson²,

Ogier³

et al. 1989

Annals of the New York Academy of Sciences

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Calcium-mobilizing receptors appear to induce calcium movements from both intracellular and extracellular sites.' The mechanism of the Ca2+ influx component remains enigmatic, being probably independent from voltage-sensitive Caz+ channels because it occurs in both excitable and nonexcitable cell types. Several hypotheses for the mechanism have been proposed, including actions of inositol tetrakis-and tris-phosphates, Ca2+-activated Ca2+ channels, and the Na+ /Ca2+One further possibility is that the concomitant activation of protein kinase C (PKC) by such receptors may have a role in signaling Ca2+ influx.Luteinizing hormone-releasing hormone ( LHRH) and thyrotrophin-releasing hormone (TRH) both act through this class of receptor, causing calcium mobilization and phosphoinositide hydrolysis. The Ca-influx processes activated by these hormone receptors in anterior pituitary tissue can be measured by a rapid "Ca2+ influx assay, involving quenching, filtration, and washing with EGTA-containing medium.' The 4sCa2+ influx induced by LHRH, TRH, or K + was maximal by 30 seconds and was concentration dependent, with peak increases over basal "Ca2+ accumulation of 83 2 8% (100 nM LHRH), 162 * 14% (300 nM TRH), and 232 2 30% (60 mM

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Luteinizing hormone-releasing hormone rapidly elicits an opening of membrane Ca2+ channels which is suppressed by protein kinase C

Cited by 2 publications

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Regulation of receptor-operated Ca2+ influx by protein kinase C

Regulation of receptor-operated Ca2+ influx by protein kinase C

Regulation of Receptor‐Operated and Depolarization‐Operated Ca²⁺ Influx in Anterior Pituitary Tissue

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Luteinizing hormone-releasing hormone rapidly elicits an opening of membrane Ca2+ channels which is suppressed by protein kinase C

Cited by 2 publications

References 0 publications

Regulation of receptor-operated Ca2+ influx by protein kinase C

Regulation of receptor-operated Ca2+ influx by protein kinase C

Regulation of Receptor‐Operated and Depolarization‐Operated Ca2+ Influx in Anterior Pituitary Tissue

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Product

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Regulation of Receptor‐Operated and Depolarization‐Operated Ca²⁺ Influx in Anterior Pituitary Tissue