Luteinizing Hormone-Releasing Hormone Receptor Bindings of the Hen Pituitary: Difference Between Laying and Nonlaying Hens, Effects of Ovarian Steroid Hormones In Vivo, and Changes During an Ovulatory Cycle

Kawashima, Mitsuo; Takeo, Hiroyuki; Kamiyoshi, Michiharu; Tanaka, Katuhide

doi:10.3382/ps.0711079

Cited by 23 publications

(14 citation statements)

References 27 publications

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“…In chicken ovary, progesterone is produced by the granulosa cells of yellow hierarchical follicles under the stimulatory control of LH, whereas oestradiol is produced by the stromal tissue and the theca cells of white and yellow follicles (for review, see Johnson, 1996). The fall in plasma LH, progesterone and oestradiol concentrations during fasting is the result of reduced pituitary response to LH releasing hormone (Tanabe et al, 1981;Kawashima et al, 1992). However, the present results indicate that the effect of exogenous leptin on ovarian steroidogensis cannot be explained only by its stimulatory action at the central level as higher ovarian progesterone and oestradiol concentrations were observed in leptin-treated hens after 5 days of fasting without any difference in LH concentrations.…”

Section: Discussioncontrasting

confidence: 51%

Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus)

Paczoska-Eliasiewicz¹,

Gertler²,

Proszkowiec³

et al. 2003

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Section: Discussioncontrasting

confidence: 51%

Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus)

Paczoska-Eliasiewicz¹,

Gertler²,

Proszkowiec³

et al. 2003

Reproduction

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“…Gonadotroph cells of the anterior pituitary gland produce both luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which play fundamental roles in the control of ovarian function in the domestic hen. Pituitary gonadotrophin secretion is regulated by the hypothalamic peptide gonadotrophin-releasing hormone (GnRH; also known as LHRH-I; King et al 1989), acting through GnRH receptors (GnRH-Rs; Millar & King 1983, Kawashima et al 1992a. Ovarian steroid-feedback mechanisms also modulate gonadotrophin secretion through both direct and indirect (GnRH-mediated) actions (Luck & Scanes 1980, King et al 1989, Kawashima et al 1992b.…”

Section: Introductionmentioning

confidence: 99%

Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle

Lovell

Knight²,

Gladwell³

2005

Journal of Endocrinology

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Secretion of LH and FSH from the anterior pituitary is regulated primarily by hypothalamic GnRH and ovarian steroid hormones. More recent evidence indicates regulatory roles for certain members of the transforming growth factor (TGF ) superfamily including inhibin and activin. The aim of this study was to identify expression of mRNAs encoding key receptors and ligands of the inhibin/activin system in the hen pituitary gland and to monitor their expression throughout the 24-25-h ovulatory cycle. Hens maintained on long days (16 h light/ 8 h dark) were killed 20, 12, 6 and 2 h before predicted ovulation of a midsequence egg (n=8 per group). Anterior pituitary glands were removed, RNA extracted and cDNA synthesized. Plasma concentrations of LH, FSH, progesterone and inhibin A were measured. Realtime quantitative PCR was used to quantify pituitary expression of mRNAs encoding betaglycan, activin receptor (ActR) subtypes (type I, IIA), GnRH receptor (GnRH-R), LH subunit, FSH subunit and GAPDH. Levels of mRNA for inhibin/activin A and B subunits, inhibin subunit, follistatin and ActRIIB mRNA in pituitary were undetectable by quantitative PCR (<2 amol/reaction). Significant changes in expression (P<0·05) of ActRIIA and betaglycan mRNA were found, both peaking 6 h before ovulation just prior to the preovulatory LH surge and reaching a nadir 2 h before ovulation, just after the LH surge. There were no significant changes in expression of ActRI mRNA throughout the cycle although values were correlated with mRNA levels for both ActRIIA (r=0·77; P<0·001) and betaglycan (r=0·45; P<0·01). Expression of GnRH-R mRNA was lowest 20 h before ovulation and highest (P<0·05) 6 h before ovulation; values were weakly correlated with betaglycan (r=0·33; P=0·06) and ActRIIA (r=0·34; P=0·06) mRNA levels. Expression of mRNAs encoding LH and FSH subunit were both lowest (P<0·05) after the LH surge, 2 h before ovulation. These results are consistent with an endocrine, but not a local intrapituitary, role of inhibin-related proteins in modulating gonadotroph function during the ovulatory cycle of the hen, potentially through interaction with betaglycan and ActRIIA. In contrast to mammals, intrapituitary expression of inhibin/activin subunits and follistatin appears to be extremely low or absent in the domestic fowl.

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“…injection of cCT increased the binding affinity and decreased the binding capacity of CT receptor in the neurohypophysis (Table 1). Such changes in the receptor binding are also reported in AVT receptor of the hen uterus (Takahashi et al, 1994b) and in luteinizing hormone-releasing hormone receptor of the hen pituitary (Kawashima et al, 1992). Although it is obscure what is the trigger of CT action on neurohypophysis at a close time of oviposition, the initial CT action may be caused by an increase in plasma CT levels.…”

Section: Discussionmentioning

confidence: 90%

Calcitonin receptor binding in the hen neurohypophysis before and after oviposition

et al. 2010

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To demonstrate the presence of a receptor for calcitonin (CT) in the hen neurohypophysis and to estimate the time of action of CT on the neurohypophysis during the oviposition cycle in relation to arginine vasotocin (AVT) release, binding of (125)I-labeled chicken CT in plasma membrane fractions of the hen neurohypophysis was measured by the use of a radioligand binding assay. The binding specificity, reversibility, high affinity, and limited capacity are characteristics of a CT receptor. Therefore, it was elucidated that the CT receptor might exist in the plasma membrane of the neurohypophysis of hens. The binding affinity of CT receptor increased at 30 min before oviposition and the binding capacity was decreased at 15 min before oviposition. However, no change was found in non-laying hens during a 24-h period. Such changes in the CT receptor binding were found at 10 min after an i.v. injection of chicken CT into non-laying hens with an increase in the blood level of AVT. The changes in the binding affinity and capacity of CT receptor of the neurohypophysis may be related to AVT release partly at oviposition time in the hen.

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Luteinizing Hormone-Releasing Hormone Receptor Bindings of the Hen Pituitary: Difference Between Laying and Nonlaying Hens, Effects of Ovarian Steroid Hormones In Vivo, and Changes During an Ovulatory Cycle

Cited by 23 publications

References 27 publications

Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus)

Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus)

Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle

Calcitonin receptor binding in the hen neurohypophysis before and after oviposition

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