Luteolin, a food‐derived flavonoid, suppresses adipocyte‐dependent activation of macrophages by inhibiting JNK activation

Abstract

a b s t r a c tInteraction between adipocytes and macrophages contributes to the development of insulin resistance in obese adipose tissues. In this study, we examined whether luteolin, food-derived flavonoid, could suppress the production of inflammatory mediators of the interaction between adipocytes and macrophages. Experiments using a coculture system of adipocytes and macrophages showed that luteolin suppressed the production of inflammatory mediators. In addition, activated macrophages were targets for the suppressive effect of luteolin. Luteolin inhibited the phosphorylation of JNK and suppressed the production of inflammatory mediators in the activated macrophages. The findings indicate that luteolin can inhibit the interaction between adipocytes and macrophages to suppress the production of inflammatory mediators, suggesting that luteolin is a valuable foodderived compound for the treatment of metabolic syndrome.

(−)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression

“…Phenolic flavonoids found in plants and fruits have been widely studied and shown to have beneficial effects on human health (Ando et al, 2009;Kim et al, 2006;Pinent et al, 2005). The main active component in green tea, (−)-epigallocatechin-3-gallate (EGCG), has shown inhibitory effects on weight gain in rat models (Ashida et al, 2004;Bose et al, 2008;Chen et al, 2009;Diepvens et al, 2006;Nagao et al, 2009;Richard et al, 2009;Wolfram et al, 2005).…”

Effects of Chondroitin Sulfate and Its Oligosaccharides on Toll-Like Receptor-Mediated IL-6 Secretion by Macrophage-Like J774.1 Cells

“…Many polyphenols that suppress macrophage functions have been reported. 42,43) Arthritis is often accompanied by bacterial/viral infection, which causes macrophage activation. CS is a Di-4S, the disaccharide unit of CS-A, is sulfated on C-4 of the galactosamine, whereas Di-6S, the disaccharide unit of CS-C, is sulfated on C-6 of the galactosamine.…”

Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

“…Так, ЛТ ингибирует освобождение фактора некроза опухоли-a (ФНОa) и активацию ядерного фактора NF-kB в макрофагах, индуцируемых ЛПС, уменьшает уровни мРНК TNFa, интерлейкина-6 (ИЛ-6) и моноцитарного хемотаксического фактора-1 (MХФ-1). При стимуляции инсулином он усиливает потребление глюкозы адипоцитами, увеличивает экспрессию генов адипонектина и лептина, но особенно чётко в присутствии ЛТ возрастает транскрипционная активность РАППg [38,39].…”