Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics

Han, Kun; Lang, Tingyuan; Zhang, Zhiqi; Zhang, Yi; Sun, Yongning; Shen, Zan; Beuerman, Roger W.; Zhou, Lanlan; Min, Daliu

doi:10.1038/s41598-018-26761-2

Cited by 49 publications

(23 citation statements)

References 40 publications

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“…Luteolin inhibited the migration of PC-3 cells in transwell and wound healing assays. Moreover, it decreased spheroid formation and self-renewal (or stemness) of these cells by up-regulating frizzled class receptor 6, a negative regulator of the Wnt pathway, that plays an important role in tumorigenesis (133) . Another study using U-87 MG and U-251 MG glioblastoma cells demonstrated that luteolin inhibited epidermal growth factor receptor (EGFR) and its downstream Akt and MAPK signalling pathways.…”

Section: Luteolinmentioning

confidence: 99%

Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review

et al. 2019

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Despite the much improved therapeutic approaches for cancer treatment that have been developed over the past 50 years, cancer remains a major cause of mortality globally. Considerable epidemiological and experimental evidence has demonstrated an association between ingestion of food and nutrients with either an increased risk for cancer or its prevention. There is rising interest in exploring agents derived from natural products for chemoprevention or for therapeutic purposes. Honey is rich in nutritional and non-nutritional bioactive compounds, as well as in natural antioxidants, and its potential beneficial function in human health is becoming more evident. A large number of studies have addressed the anti-cancer effects of different types of honey and their phenolic compounds using in vitro and in vivo cancer models. The reported findings affirm that honey is an agent able to modulate oxidative stress and has anti-proliferative, pro-apoptotic, anti-inflammatory, immune-modulatory and anti-metastatic properties. However, despite its reported anti-cancer activities, very few clinical studies have been undertaken. In the present review, we summarise the findings from different experimental approaches, including in vitro cell cultures, preclinical animal models and clinical studies, and provide an overview of the bioactive profile and bioavailability of the most commonly studied honey types, with special emphasis on the chemopreventive and therapeutic properties of honey and its major phenolic compounds in cancer. The implications of these findings as well as the future prospects of utilising honey to fight cancer will be discussed.

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Section: Luteolinmentioning

confidence: 99%

Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review

et al. 2019

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“…prostate and oral cancer (Tu et al, 2016;Han et al, 2018b) Naringenin anti-proliferation CCND1, EREG, ESR2, MAPK1/14 cervical, colon, colorectal cancer, and hepatocarcinoma (Totta et al, 2004;Song et al, 2015;Zhang et al, 2016) Targets Cancer types Ref inhibiting metastasis AKT1, CDH1, MAPK1/4, MMP2/9, NCL, NFKB, PKCZ, PKCE, RAC1, RHO, RHOA, SCN9A, SNAIL1/2, TGFB1, TWIST1, VIM breast, lung, and bladder cancer (Liao et al, 2014;Zhang et al, 2016;Chang et al, 2017;Aktas and Akgun, 2018;Han et al, 2018c;Zhao et al, 2019b) promoting apoptosis AKT1, MAP3K5, ATF3, BAX, BCL2, BIRC5, CASP3/9, JNK, MAPK1/3/14, TP53, RPS6KB1, ROS1, RPS6…”

Section: Discussionmentioning

confidence: 99%

Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics

Cao

Han

et al. 2020

Front. Pharmacol.

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Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via multiple targeting. However, there is no systematical analysis on the interaction network of "multiple ingredients-multiple targets-multiple pathways" anticancer effects of Litchi. In this study, we summarized the confirmed anticancer ingredients and molecular targets of Litchi based on published articles and applied network pharmacology approach to explore the complex mechanisms underlying these effects from a perspective of system biology. The top ingredients, top targets, and top pathways of each anticancer function were identified using network pharmacology approach. Further intersecting analyses showed that Epigallocatechin gallate (EGCG), Gallic acid, Kaempferol, Luteolin, and Betulinic acid were the top ingredients which might be the key ingredients exerting anticancer function of Litchi, while BAX, BCL2, CASP3, and AKT1 were the top targets which might be the main targets underling the anticancer mechanisms of these top ingredients. These results provided references for further understanding and exploration of Litchi as therapeutics in cancer as well as the application of "Component Formula" based on Litchi's effective ingredients.

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“…Notably, the spheres were used. iTRAQ analysis was performed as described previously [ 28 , 29 ] with minor modified. Briefly, SOX4-overexpressing HCT-116 and control cells were cultured in ultra-low attachment plate for sphere formation.…”

Section: Methodsmentioning

confidence: 99%

SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study

et al. 2021

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Background Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has been identified in many types of human cancer and promotes cancer development. However, the role of SOX4 in CSCs, especially at a proteome-wide level, has remained elusive. The aim of this study is to investigate the effect of SOX4 on the stemness of CSCs and reveal the underlying mechanisms by identification of SOX4-induced proteome changes through proteomics study. Results Overexpression of SOX4 promotes sphere formation and self-renewal of colorectal cancer cells in vitro and in vivo and elevates the expression levels of CSCs markers. Through iTRAQ-based quantitative proteomics analysis, 215 differentially expressed proteins (128 upregulated, 87 downregulated) in SOX4-overexpressing HCT-116 spheres were identified. The bioinformatic analysis highlighted the importance of HDAC1 as the fundamental roles of its impacted pathways in stem cell maintenance, including Wnt, Notch, cell cycle, and transcriptional misregulation in cancer. The mechanistic study showed that SOX4 directly binds to the promoter of HDAC1, promotes HDAC1 transcription, thereby supporting the stemness of colorectal cancer cells. HDAC1 hallmarks colorectal cancer stem cells and depletion of HDAC1 abolished the stimulatory effect of SOX4. Furthermore, SOX4-HDAC1 axis is conserved in multiple types of cancer. Conclusions The results of this study reveal SOX4-induced proteome changes in HCT-116 spheres and demonstrates that transcriptional activation of HDAC1 is the primary mechanism underlying SOX4 maintaining CSCs. This finding suggests that HDAC1 is a potential drug target for eradicating SOX4-driven human CSCs.

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Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics

Cited by 49 publications

References 40 publications

Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review

Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review

Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics

SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study

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