Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages

Chen, Dan; Bi, Aijing; Dong, Xiaoliang; Jiang, Yi Deng; Rui, Bing; Liu, Jinjiao; Yin, Zhimin; Luo, Lan

doi:10.1016/j.bbrc.2013.11.122

Cited by 62 publications

(38 citation statements)

References 22 publications

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“…In this study, the authors showed for the first time that HEVP and EAEVP have topical anti-inflammatory effect, which is possibly related to the presence of secondary compounds, since some flavonoids (rutin, luteolin, and apigenin) were identified in EAEVP and this effect may involve different mechanisms in the cutaneous inflammation [28,29]. Rutin, for example, inhibited the xilol-induced ear edema and reduced the cell migration and the levels of cytokines were also observed [30], while luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages [31]. In addition, apigenin has been effective against the LPS-induced acute lung injury due to its ability of primary inhibition of cyclooxygenase-2 (COX-2) gene expression and nuclear factor kB (NF-kB) gene expression and the protective mechanism of apigenin may be attributed partly to decreased production of proinflammatory cytokines [32].…”

Section: Discussionmentioning

confidence: 99%

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

Rodrigues

Chibli

Santos

et al. 2016

IJMS

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Vernonia polyanthes Less. (Asteraceae), popularly known as “assa-peixe”, is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical anti-inflammatory effects of the hexane (HEVP) and ethyl acetate (EAEVP) extracts from V. polyanthes leaves in experimental models of skin inflammation. Chemical characterization was carried out by HPLC–UV/DAD analysis. Anti-inflammatory activity was evaluated using Croton oil-, arachidonic acid (AA)-, phenol-, ethyl phenylpropiolate (EPP)-, and capsaicin-induced ear edema models in mice. Histopathological evaluation and measurements of myeloperoxidase (MPO) and N-acetyl-β-d-glucosaminidase (NAG) enzymes were also performed. Rutin, luteolin, and apigenin were identified in EAEVP. Topically applied HEVP and EAEVP significantly (p < 0.05, p < 0.01 or p < 0.001) reduced edema induced by five different irritants at the doses tested (0.1, 0.5 and 1.0 mg/ear). Histopathological analysis revealed a reduction of edema, inflammatory cell infiltration, and vasodilation. In addition, the enzymes activity (MPO and NAG) in the ear tissues was reduced by the topical treatment of HEVP and EAEVP (p < 0.05, p < 0.01 or p < 0.001). The results suggest that V. polyanthes leaves are effective against cutaneous damage, which support its traditional use and open up new possibilities for the treatment of skin disorders.

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Section: Discussionmentioning

confidence: 99%

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

Rodrigues

Chibli

Santos

et al. 2016

IJMS

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“…More recently, also in RAW 264.7 cell line, luteolin inhibited TNF‐α production, but did not suppress LPS‐induced NF‐ĸB and MAPKs signaling. On the other hand, it markedly attenuated LPS‐activated phosphorylation of the JNK downstream c‐Jun and Jun‐2 luciferase reporter activity …”

Section: Inflammatory Mediatorsmentioning

confidence: 63%

Proinflammatory Pathways: The Modulation by Flavonoids

Ribeiro

Freitas

Lima

et al. 2015

Medicinal Research Reviews

110

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Inflammation is a natural, carefully orchestrated response of the organism to tissue damage, involving various signaling systems and the recruitment of inflammatory cells. These cells are stimulated to release a myriad of mediators that amplify the inflammatory response and recruit additional cells. These mediators present numerous redundancies of functions, allowing a broad and effective inflammatory response, but simultaneously make the understanding of inflammation pathways much difficult. The extent of the inflammatory response is usually self-limited, although it depends on the balance between the pro- and anti-inflammatory signals. When that equilibrium is dislocated, a more widespread inflammatory response may take place. Flavonoids have been shown to be possible alternatives to the traditionally molecules used as anti-inflammatory agents. In fact, the biological activities of flavonoids include the modulation of the diverse phases of inflammatory processes, from the gene transcription and expression to the inhibition of the enzymatic activities and the scavenging of the reactive species. In the present review, the inflammatory network is widely revised and the flavonoids' broad spectrum of action in many of the analyzed inflammatory pathways is revised. This kind of integrated revision is original in the field, providing the reader the simultaneous comprehension of the inflammatory process and the potential beneficial activities of flavonoids.

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“…Luteolin destabilized the Hsp90 client protein c-Jun and Akt and inhibited LPS-induced production of TNF-α and NO dose-dependently in macrophages [73]. In addition, luteolin prevented TNF-α-induced endolytic monocyte adhesion in mice by suppressing vascular inflammation and the IKBα/NF-κB pathway in HUVECs [74].…”

Section: Luteolinmentioning

confidence: 94%

Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity

Gezer¹

2018

Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics

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The stress responses observed in mammalian cells can be classified as heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid damage response, antioxidant response, and sirtuin response at the intracellular and molecular levels. Factors that strengthen the hemodynamic structure causing low-level molecular damage and activating one or several stress response pathways are called hormetins. Hormetins can be categorized as physical, physiological, biological, and nutritional hormetins. Nutritional hormetins provide an interesting, comprehensive research topic because of their effects on health and lifespan. Dietary phytochemicals, with their low-level stress-inducing effects, are potential nutritional hormetins. Resveratrol, curcumin, epicatechin, isothiocyanates, ferulic acid, and certain vitamin-minerals can induce a heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid damage response, antioxidant response, and sirtuin response causing the stimulation of kinases and transcription factors. Studies have shown that these phytochemicals are related to nuclear factor-erythroid 2, sirtuins, nuclear factor-kappa B, and heat shock response pathways. In this chapter, the stress response of dietary phytochemicals will be systematically examined in a hormetic manner for delay of age-related diseases, healthy aging, and longevity based on current data.

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Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages

Cited by 62 publications

References 22 publications

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

Proinflammatory Pathways: The Modulation by Flavonoids

Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity

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