2014
DOI: 10.1111/jphp.12280
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Luteolin-phospholipid complex: preparation, characterization and biological evaluation

Abstract: LPC was successfully prepared by optimizing the process parameters. The resultant delivery system improved bioavailability and efficacy of luteolin and in the future may become an efficient tool for administration of luteolin.

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Cited by 55 publications
(28 citation statements)
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“…The peak at 1070 cm -1 represented stretching of P-O-C of a phosphate group. A similar observation was reported by the other workers [35,36] . FTIR spectra of physical mixture and phospholipid complex are represented in fig.…”
Section: Resultssupporting
confidence: 92%
“…The peak at 1070 cm -1 represented stretching of P-O-C of a phosphate group. A similar observation was reported by the other workers [35,36] . FTIR spectra of physical mixture and phospholipid complex are represented in fig.…”
Section: Resultssupporting
confidence: 92%
“…These findings are in accordance with previously reported results. The interactions between the SBE and Phospholipon Ā® 90H can be attributed to a combination of forces such as hydrogen bonding and/or van der Waals interactions, and can be considered as an indication of drug amorphization and/or complex formation, as supported by IR spectroscopy (Khan et al, 2014;Zhang et al, 2015). The interactions of the SBE with the polar region of Phospholipon Ā® 90H are likely followed by the intercalation of the SBE within the hydrophobic domains of the phospholipid molecules.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…For instance, inclusion complex formation of luteolin with cyclodextrins improved the antioxidant activity of luteolin which could be due to improved solubility and bioavailability of luteolin [33,34]. Similarly, complexation of luteolin with phospholipids is reported to improve cellular uptake, bioavailability and efficacy of luteolin [35][36][37]. Nanofabrication and nano-encapsulations have also been reported with enhanced solubility, bioavailability and efficacy of luteolin.…”
Section: Introductionmentioning
confidence: 99%