Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways

Albarakati, Alaa Jameel A.; Baty, Roua S.; Aljoudi, Ahmad M; Habotta, Ola A.; Elmahallawy, Ehab Kotb; Kassab, Rami B.; Moneim, Ahmed E. Abdel

doi:10.1007/s11033-020-05346-1

Cited by 92 publications

(57 citation statements)

References 59 publications

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“…In the cytoplasm, it is attached to the Kelch-like erythroid cell-derived protein 1 (Keap1). When the cell becomes under oxidative stress conditions, it moves to the nucleus, binds with the antioxidant response element, and stimulates HO-1 [ 43 ]. Previous reports stated that BER activated markedly Nrf2 nuclear translocation in different disease models [ 44 – 46 ].…”

Section: Discussionmentioning

confidence: 99%

Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways

Xue

Liu

et al. 2020

Mediators of Inflammation

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Berberine (BER), a natural isoquinoline alkaloid, has been demonstrated to have appreciable anticolitis effects. Nevertheless, the protective mechanism of BER in ulcerative colitis (UC) is barely understood. The present study was aimed at exploring the therapeutic efficacy of BER on UC in experimental colitis rat model. Rats were orally administered with BER for seven days at low and high doses (25 and 50 mg/kg/day) before AcOH intracolonic instillation. BER significantly retrieved colon inflammation and mucosal damage indicated by inhibition of macroscopic score and lessened the levels of inflammatory biomarkers (IL-1β, IL-6, TNF-α, MPO, and PGE2). Notable downregulation of mRNA expression of p38 MAPK and increased protein expression of TGF-β were achieved by BER treatment. The anti-inflammatory potential of BER was supported by the histopathological screening of colon mucosa. In addition, BER restored colonic antioxidant capacity through elevation of GSH level and antioxidant enzymatic activities (SOD, CAT, GPx, and GR) together with reductions of both MDA and NO levels. Marked downregulation of Nos2 mRNA expression is accompanied by increased Nrf2 and Hmox-1 expressions in colon specimens treated by BER. Furthermore, BER exhibited noticeable antiapoptotic activities through decreasing proapoptotic proteins (Bax and caspase-3) and lessening antiapoptotic Bcl-2 protein in the colon mucosa. Based on these findings, BER may improve colitis markedly which may be mediated by its striking antioxidant, anti-inflammatory, and antiapoptotic properties.

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Section: Discussionmentioning

confidence: 99%

Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways

Xue

Liu

et al. 2020

Mediators of Inflammation

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“…Flavonoids are found in fruits and vegetables with a variable phenolic structure. The flavonoids, soused in various pharmaceutical and medical supplements [ 13 , 14 ], have many beneficial effects on health, including their anti-inflammatory, anti-apoptotic and anti-oxidant effects. They have the ability to scavenge reactive oxygen species (ROS) and activate enzymes that are anti-oxidant in nature, and they can reduce the concentration of substances that have an active role in producing ROS [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

et al. 2020

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Neurodegenerative disorders have emerged as a serious health issue in the current era. The most common neurodegenerative disorders are Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). These diseases involve progressive impairment of neurodegeneration and memory impairment. A wide range of compounds have been identified as potential neuroprotective agents against different models of neurodegeneration both in vivo and in vitro. Hesperetin, a flavanone class of citrus flavonoid, is a derivative of hesperidin found in citrus fruits such as oranges, grapes, and lemons. It has been extensively reported that hesperetin exerts neuroprotective effects in experimental models of neurodegenerative diseases. In this systematic review, we have compiled all the studies conducted on hesperetin in both in vivo and in vitro models of neurodegeneration. Here, we have used an approach to lessen the bias in each study, providing a least biased, broad understanding of findings and impartial conclusions of the strength of evidence and the reliability of findings. In this review, we collected different papers from a wide range of journals describing the beneficial effects of hesperetin on animal models of neurodegeneration. Our results demonstrated consistent neuroprotective effects of hesperetin against different models of neurodegeneration. In addition, we have summarized its underlying mechanisms. This study provides the foundations for future studies and recommendations of further mechanistic approaches to conduct preclinical studies on hesperetin in different models.

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“…18 Lead acetate within cells is degraded, releasing Pb 2+ . 19 Pb 2+ can inhibit the action of SOD enzyme, which is a metalloenzyme, and requires metal cofactors for its antioxidant activity. SOD binds metal ions of zinc (Zn) and copper (Cu) that act as the cofactor.…”

Section: Discussionmentioning

confidence: 99%

Nanocurcumin Potential Effect of SOD Enzyme and Caspase-3 Expression in Lead-Acetate Induced Rats Ovarian Granulosa Cells

Syarifah¹,

Sudjarwo²,

Hendarto³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Aim: This study investigated the potential effect of nanocurcumin on the increase of SOD enzyme expression and decrease of caspase-3 in lead acetate-induced rats ovarian granulosa cells.Materials and Methods: Forty five female rats were divided into 5 groups, the negative control group (rats receiving corn oil, one hour later receiving distilled water), positive control group (rats receiving corn oil, one hour later receiving lead acetate of 40 mg/kg bw) and experimental groups 1, 2 and 3 (rats receiving nanocurcumin 50 mg, 100 mg and 200 mg/kg bw). One hour after administering the nanocurcumin, the rats received 40 mg/kg of lead acetate. All groups received oral treatment once a day for 26 days. On day 27 the rats were sacrificed and the expression of SOD and caspase-3 enzymes were measured using immunohistochemical methods.Results: This study found that lead acetate decreased SOD enzyme expression and increased caspase-3. In contrast, nanocurcumin increased SOD enzyme and decreased caspase-3 expression in lead acetate-induced rats ovarian granulosa cells. Conclusion:Nanocurcumin has potential as a strong natural antioxidant by affecting the increase of SOD and the decrease of caspase-3 cells in lead acetate-induced rats ovarian granulosa cells.

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Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways

Cited by 92 publications

References 59 publications

Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways

Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways

Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

Nanocurcumin Potential Effect of SOD Enzyme and Caspase-3 Expression in Lead-Acetate Induced Rats Ovarian Granulosa Cells

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