Luteolin shows antidepressant-like effect by inhibiting and downregulating plasma membrane monoamine transporter (PMAT, Slc29a4)

Zhu, Shujie; Lei, Shaowei; Zhou, Sisi; Jin, Luhong; Zeng, Su; Jiang, Huidi; Zhou, Hui

doi:10.1016/j.jff.2019.01.048

Cited by 17 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, quercetin exerts antidepressant effects by exerting antioxidant and anti-inflammatory activities, decreasing cytotoxicity, and increasing 5-hydroxytryptamine levels [ 34 ]. Luteolin is derived from Triticum aestivum L. It has been reported that luteolin exerts an antidepressant effect by suppressing the endoplasmic reticulum [ 35 ] and inhibiting and downregulating plasma membrane monoamine transporters (PMAT, Slc29a4) [ 36 ]. It has also been found that luteolin may improve cognitive performance by inhibiting microglial activation and neuroinflammation in older mice [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking

Ding

Sun

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Poststroke depression (PSD) is the most common and serious neuropsychiatric complication occurring after cerebrovascular accidents, seriously endangering human health while also imposing a heavy burden on society. Nevertheless, it is difficult to control disease progression. Gan-Mai-Da-Zao Decoction (GMDZD) is effective for PSD, but its mechanism of action in PSD is unknown. In this study, we explored the mechanism of action of GMDZD in PSD treatment using network pharmacology and molecular docking. Material and methods. We obtained the active components of all drugs and their targets from the public database TCMSP and published articles. Then, we collected PSD-related targets from the GeneCards and OMIM databases. Cytoscape 3.8.2 was applied to construct PPI and composite target disease networks. In parallel, the DAVID database was used to perform GO and KEGG enrichment analyses to determine the biological processes enriched in the treatment-related drugs in vivo. Finally, molecular docking was used to verify the association between the main active ingredients and their targets. Results. The network pharmacological analysis of GMDZD in PSD revealed 107 active ingredients with important biological effects, including quercetin, luteolin, kaempferol, naringenin, and isorhamnetin. In total, 203 potential targets for the treatment of this disease were screened, including STAT3, JUN, TNF, TPT53, AKT1, and EGFR. These drugs are widely enriched in a series of signaling pathways, such as TNF, HIF-1, and toll-like receptor. Moreover, molecular docking analysis showed that the core active components were tightly bound to their core targets, further confirming their anti-PSD effects. Conclusion. This prospective study was based on the integrated analysis of large data using network pharmacology technology to explore the feasibility of GMDZD for PSD treatment that was successfully validated by molecular docking. It reflects the multicomponent and multitarget characteristics of Chinese medicine and, more importantly, brings hope for the clinical treatment of PSD.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking

Ding

Sun

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The amount of each compound was also quantitatively analysed by HPLC and we found that the major components in this KBD formula were madecassoside (179 mg/g extract), asiaticoside (57 mg/g extract), and piperine (10 mg/g extract), respectively [ 21 ]. Accumulation evidences demonstrate that the chemical constituents of KBD extract which are relevant to antidepressant activity are madecassoside, asiaticoside, piperine, quercetin, kaempferol, kaempferol-3-glucoside, rutin, luteolin-7- O -glucoside, and ferulic acid [ 21 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. Asiaticoside, one of the triterpenoid compounds isolated from C. asiatica , has been demonstrated to increase sucrose consumption and reduced immobility time in FST and TST, and downregulate IL-1β, IL-6, and TNF-α in the hippocampus [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results showed that piperine reversed the effect of corticosterone treatment via increased BDNF protein and mRNA levels in the hippocampus [ 59 ]. A recently report studying the antidepressant-like effects of luteolin showed that it elevated the monoamine neurotransmitters levels in the synaptic cleft and upregulated BDNF expression in hippocampus [ 60 ]. Kaempferol and quercetin, two flavonoids commonly found in medicinal plants exhibited antidepressant activity by reducing the immobility time in FST and TST in stressed mice compared with unstressed mice [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Merging the Multi-Target Effects of Kleeb Bua Daeng, a Thai Traditional Herbal Formula in Unpredictable Chronic Mild Stress-Induced Depression

et al. 2021

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a common and debilitating psychiatric disease characterized by persistent low mood, lack of energy, hypoactivity, anhedonia, decreased libido, and impaired cognitive and social functions. However, the multifactorial etiology of MDD remains largely unknown due the complex interaction between genetics and environment involved. Kleeb Bua Daeng (KBD) is a Thai traditional herbal formula that has been used to promote brain health. It consists of a 1:1:1 ratio of the aerial part of Centella asiatica, Piper nigrum fruit, and the petals of Nelumbo nucifera. According to the pharmacological activities of the individual medicinal plants, KBD has good potential as a treatment for MDD. The present study investigated the antidepressant activity of KBD in an unpredictable chronic mild stress (UCMS) mouse model. Daily administration of KBD to UCMS mice ameliorated both anhedonia, by increasing 2% sucrose intake, and hopeless behavior, by reducing immobility times in the forced swimming test (FST) and tail suspension test (TST) without any effect on locomotor activity. The mechanism of KBD activity was multi-modal. KBD promoted neurogenesis by upregulation of brain-derived neurotrophic factor (BDNF) and cyclic AMP-responsive element binding (CREB) mRNA expression in the frontal cortex and hippocampus. Daily treatment with KBD significantly reversed UCMS-induced HPA axis dysregulation by upregulating the glucocorticoid receptor (GR) while downregulating serum- and glucocorticoid-inducible kinase 1 (SGK1) and FK506 binding protein 5 (FKBP5) mRNA expression. KBD treatment also normalized proinflammatory cytokine expression including tumor necrosis factor-alpha (TNF-α), and interleukin (IL)-1β and IL-6. KBD and its component extracts also exhibited an inhibitory effect in vitro on monoamine oxidase (MAO) A and B. The multiple antidepressant actions of KBD emphasize its potential as an effective, novel treatment for MDD.

show abstract

“…Oral administration of luteolin, at a dose of 50 mg/kg, resulted in antidepressant effects in FST and TST. Luteolin raised the levels of monoamine neurotransmitters in the synaptic cleft by directly and indirectly inhibiting serotonin uptake [34]. Kaemferol also exhibited the antidepressant activity by reducing the immobility time in FST and TST in stress-induced mice compared with unstressed mice [35].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action

et al. 2019

View full text Add to dashboard Cite

Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of Dipterocarpus alatus leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST)). The extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis, caused by UCMS, but also ameliorated UCMS-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) mRNA expression and down-regulation of cyclic AMP-responsive element binding (CREB) and brain-derived neurotrophic factor (BDNF) mRNAs in frontal cortex and hippocampus. In vitro monoamine oxidase (MAO) inhibition assays showed that the extract exhibited the partial selective inhibition on MAO-A. HPLC analysis of the extract showed the presence of flavonoids (luteolin-7-O-glucoside, kaempferol-3-glucoside, rutin) and phenolic acids (gallic acid, ferulic acid, and caffeic acid) as major constituents.

show abstract

Luteolin shows antidepressant-like effect by inhibiting and downregulating plasma membrane monoamine transporter (PMAT, Slc29a4)

Cited by 17 publications

References 43 publications

Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking

Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking

Merging the Multi-Target Effects of Kleeb Bua Daeng, a Thai Traditional Herbal Formula in Unpredictable Chronic Mild Stress-Induced Depression

Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action

Contact Info

Product

Resources

About