Luteolysis following intra-arterial infusion of prostaglandin F2  directly into the ovine autotransplanted ovary

Wa, Chamley; Jm, Brown; Cain,; Jc, Cerini; Me, Cerini; Cumming, I. A.; Goding,; Kragt, Clifford L.

doi:10.1530/jrf.0.0280153

Cited by 9 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various investigations have shown an association between estradiol and PGF in their actions on luteal function (Barrett et al, 1971;Chamley et al, 1972;Ford et al, 1973). aBlood was collected from same side as corpus luteum in unilaterally-ovulating ewes and from one side at random in bilaterally-ovulating ewes.…”

Section: Resultsmentioning

confidence: 99%

Prostaglandins F in Uterine Venous Plasma, Ovarian Arterial and Venous Plasma and in Ovarian and Luteal Tissue of Pregnant and Nonpregnant Ewes

Pexton

Weems

Inskeep

1975

Journal of Animal Science

View full text Add to dashboard Cite

Ovarian venous, ovarian arterial and uterine venous blood were collected from the same side as a corpus luteum in 10 nonpregnant and 10 pregnant ewes at day 15 postestrus. Both ovarian and uterine venous samples were collected by venipuncture. Ovarian arterial blood was collected into heparinized centrifuge tubes after a small portion of the artery was dissected free from mesovarium and then severed. Arterial blood flow was estimated by timed collection. Ovaries and corpora lutea were removed, frozen in .vials placed in liquid nitrogen, weighed and stored at-20 C. Prostaglandins F (PGF) in plasma and tissue were quantified by use of radioimmunoassay. Nonpregnant. and pregnant ewes did not differ in concentration (ng/ml) of PGF in plasma from uterine veins (7.1 + 3.4 and 5.2 + .9), ovarian arteries (.6 + .3 and 1.1-+ .3) or ovarian veins (.6 + .1 and .8-+ .3). The rate of blood flow from the severed ovarian artery was higher (P<.05) in the pregnant ewes (4.2-+ 1.6 vs .9 + .2 ml/min). The quantity of PGF apparently being transported to the ovary in arterial plasma was higher (P<.05) in pregnant (2.1-+ .5 ng/ml) than in nonpregnant ewes (.5 + .2 ng/min).

show abstract

Section: Resultsmentioning

confidence: 99%

Prostaglandins F in Uterine Venous Plasma, Ovarian Arterial and Venous Plasma and in Ovarian and Luteal Tissue of Pregnant and Nonpregnant Ewes

Pexton

Weems

Inskeep

1975

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Moreover, the dose of 25 pg PGF-2a/h was luteolytic when infused for 6 h but not for 3 h. In addition to a critical concentration, there appears to be a threshold exposure time for PGF-2a-mediated luteolysis. In the autotransplanted sheep ovary, the minimum effective luteolytic dose of PGF-2a administered by constant rate infusion into the ovarian artery was approximately 19 pg (Chamley et al, 1972). However, McCracken, Schramm, Barcikowski & Wilson (1981) have demonstrated that the same effect can be produced with a total dose of only 300 ng PGF-2a, if it is administered as a series of injections over a 24-h period.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the luteolytic potency of various prostaglandins in the pseudopregnant rabbit

Kehl¹,

Carlson²

1981

Reproduction

View full text Add to dashboard Cite

The ability of systemic infusion of arachidonic acid and various prostaglandin (PG) compounds to induce luteolysis was examined in the Day 9 pseudopregnant rabbit. Administration of PGF-2 alpha (25 microgram/h for 6 h) elicited a decline in plasma progesterone from mean +/- s.e.m. pretreatment levels of 8.83 +/- 0.54 to 0.54 +/- 0.05 ng/ml on the following day (P less than 0.01). A shorter infusion (25 microgram/h for 3 h) or a lower hourly dose rate (12.5 microgram/h for 6 h) of PGF-2 alpha was ineffectual, suggesting that a dose/duration regimen exists for PGF-2 alpha-mediated luteolysis. PGE-2 (25 microgram/h for 6 h) or sodium arachidonate (667 microgram/h for 6 h) did not significantly affect luteal function. Of the PGF-2 alpha metabolites examined, 13,14-dihydro-PGF-2 alpha was the most effective: it was approximately 4-fold more potent as a luteolysin than PGF-2 alpha since functional regression occurred with infusion of 6.25 microgram/h for 6 h. These data illustrate that systemic infusion of PGF-2 alpha is capable of inducing luteolysis in the rabbit. The metabolite 13,14-dihydro-PGF-2 alpha may also be involved luteolytically in this species.

show abstract

“…Maternal recognition of pregnancy in sheep and cattle (d 13 and 16, respectively), has also been well-studied. As in pigs, luteolysis is caused by PGF 2a release from the uterus (Chamley et al, 1972;Cerini et al, 1973). The role of oxytocin and oxytocin receptors in this process has been clearly established.…”

Section: Embryonic Mortalitymentioning

confidence: 99%

The influence of uterine function on embryonic and fetal survival

Vallet

Leymaster

Christenson

2002

Journal of Animal Science

View full text Add to dashboard Cite

The secretion rate of growth factors and the delivery rate of nutrients by the uterus to the conceptus affects the growth rate, development, and survival of the conceptus. For most growth factors and nutrients, passage into the uterus is not simply controlled by diffusion. Many growth factors are products of uterine tissue. Transport of some nutrients is aided by specific transporter molecules on the uterine endometrial epithelial cell, whereas others (e.g., retinol, iron, and folate) are incorporated into uterine-secreted proteins (e.g., retinol binding protein, uteroferrin, and folate binding protein). The rate of production of these proteins during pregnancy profoundly affects pregnancy outcome. Uterine gland knockout experiments in sheep demonstrate that pregnancy fails in the absence of uterine glands, the source of many uterinesecreted proteins. In pigs, both global and specific effects of uterine products on aspects of conceptus development can influence litter size. The provision of growth factors and nutrients by the uterus plays a role in en

show abstract

Luteolysis following intra-arterial infusion of prostaglandin F2 directly into the ovine autotransplanted ovary

Cited by 9 publications

References 0 publications

Prostaglandins F in Uterine Venous Plasma, Ovarian Arterial and Venous Plasma and in Ovarian and Luteal Tissue of Pregnant and Nonpregnant Ewes

Prostaglandins F in Uterine Venous Plasma, Ovarian Arterial and Venous Plasma and in Ovarian and Luteal Tissue of Pregnant and Nonpregnant Ewes

Assessment of the luteolytic potency of various prostaglandins in the pseudopregnant rabbit

The influence of uterine function on embryonic and fetal survival

Contact Info

Product

Resources

About