Luteotrophic and Luteolytic Actions of LH in Hypophysectomized, Pseudopregnant Rabbits

Hilliard, Jessamine; Saldarini, Ronald J.; Spies, Harold G.; Sawyer, Charles H.

doi:10.1210/endo-89-2-513

Cited by 16 publications

(7 citation statements)

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“…This effect of FSH appears to be independent of any LH action because direct measurements of LH in plasma after administration of FSH show LH contamination to be very low, and to overcome any possible LH effect the FSH preparation was absorbed with an anti-LH serum prior to use. This finding is contrary to results in the rat (Lostroh and Johnson 1966;Armstrong 1968;Madhwa Raj et al 1968;McDonald et al 1969;Schwartz and Ely 1970;Lindner et al 1974) and the rabbit (Spies and Quadri 1967;Eaton and Hilliard 1971;Hilliard et al 1971;Mills et al 1971) which indicate that in those species LH is required for oestrogen stimulation from the ovaries.…”

Section: Discussioncontrasting

confidence: 60%

Pituitary Hormone Control of Implantation in the Mouse

Gidley-Baird¹,

Emmens²

1978

Aust. Jnl. Of Bio. Sci.

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In hypophysectomized pregnant mice replacement therapy designed to mimic the normal physiological situation showed that FSH in combination with either prolactin or LH, or prolactin plus LH, could initiate implantation in the absence of the pituitary gland. No pituitary hormone was by itself capable of achieving this result. The combination of prolactin with FSH gave better results than a combination of LH with FSH. Prolactin from sheep, cattle or rats was equally effective in combination with ratFSH in initiating implantation. In mice exhibiting suckling-induced delay of implantation this delay was terminated by injection of FSH. GH by itself or in conjunction with other hormones had no significant effect on implantation or on any of the other parameters associated with implantation that were measured.On the basis of these experimental results it is suggested that" prolactin and LH are involved with progesterone production and FSH with oestrogen production, both of which are required for implantation in the mouse.

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Section: Discussioncontrasting

confidence: 60%

Pituitary Hormone Control of Implantation in the Mouse

Gidley-Baird¹,

Emmens²

1978

Aust. Jnl. Of Bio. Sci.

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“…When mixtures of hormones are used, failure could reflect inadequate dose and/or balance between hormones, or problems associated with the use of ovine or bovine preparations in the rabbit. Hilliard, Saldarini, Spies & Sawyer (1971) successfully used a combination of 50 pg ovine LH and 200 or 300 pg ovine FSH given twice daily to hypophysectomized animals. Ovarian weight appeared to be involved; animals with small ovaries did not respond to the treatment, while pro¬ gesterone production increased in animals with larger ovaries and doubled in those with the largest ovaries.…”

Section: Discussionmentioning

confidence: 99%

Effect of the fetal placenta and of a rabbit pituitary extract on plasma progesterone in fetectomized rabbits

Lanman¹,

Thau²

1979

Reproduction

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When fetuses and placentas were removed on Day 18 in normal pregnant rabbits, plasma progesterone levels declined rapidly to non-pregnant values within 48 h. This decline was largely prevented if only fetectomy was performed, leaving the placentas in situ, but not when the fetal components of the placentas were also removed. These results suggested that ovarian progesterone production was dependent upon trophic influences emanating from the fetal portions of the placentas. Ovarian progesterone production was maintained by an extract of rabbit pituitaries for at least 72 h after removal of fetuses and placentas.

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“…Hilliard et al (1971) assumed that the luteolytic action of LH may be exerted in two ways, namely by luteinization of the follicles and thus reducing the source of estrogen, which has a luteotropic effect (Robson 1937;Hammond and Rob son 1951), and by depleting the stores of sterol precursor. This assump'" tion of Hilliard and co-workers can declare the sharp decrease in the LH level in the blood after the third day.…”

Section: Discussionmentioning

confidence: 99%

Hormonal Changes During Formation and Involution of Corpus Luteum in Rabbits

Labib¹,

Azab²,

Soliman³

1978

Acta Vet. Brno

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Labib F., E. A. El Azab, F. A. Soliman: Hormonal Changes During Formation and Involution of Corpus Luteum in Rabbits. Acta vet. Brno, 47, 1978: 23-31. A study was made on 30 female Boscat rabbits to reveal the hormonal changes, namely, TSH, FSH, LH and L TH during the formation, maintenance and involution of the corpora lutea. Induction of ovulation was done by using gonadotrophic hormones (PMS and HCG). After HCG injection the animals were devided into 3 groups of 10 animals each. They were slaughtered after 3, 7 and 15 days from HCG injection. The results observed from this experiment are as follows: 3-day old corpus luteumThe rate of synthesis and release of TSH and state of thyroid were considered in a stabilized, balanced euthyroid status. There was increased concentration of FSH in the pituitaries with a relatively low level in the blood. This indicates the inhibition of release of FSH at this stage of development of corpora lutea.The level of L TH in the pituitary was of an average value and low in the serum. 7-days old corpus luteumThe TSH content of the pituitaries was the lowest (decreased synthesis) with a mild change in its level in the blood (non-significant). The thyroids were relatively less active than in the previous group.The FSH content of the pituitaries and blood were significantly decreased (decreased synthesis and release of FSH). The LH content of the pituitaries was increased and the level in the blood was decreased (decreased release of LH).The L TH content of the pituitaries was relatively low, while that of the blood was maximal, indicating increased release of L TH. IS-day old corpus luteumThe TSH content of the pituitaries and blood were highest indicating increased synthesis and release of this hormone. The thyroid gland showed maximum activity as compared to the previous groups.The FSH content of the pituitaries was relatively low while it reached its maximum in the serum (increased rate of release of FSH). The level of LH in the pituitaries was low and that of the blood was the least. The L TH content of the pituitaries was at its maximum and it was the lowest in the blood (increased synthesis of L TH but blocked release into the blood). The results are discussed in the text. LTH, TSH, LH, FSH, pituitary, blood serum.The features of growth and maintenance of the corpus luteum, and its subsequent involution are active processes of extreme importance in regulating reproductive performance of mammals. This includes regulation of the estrous cycle, pregnancy, parturition and milk production.Any disturbance of such processes of the corpus luteum will lead to reproductive disturbances in the farm animals.

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Luteotrophic and Luteolytic Actions of LH in Hypophysectomized, Pseudopregnant Rabbits

Cited by 16 publications

References 0 publications

Pituitary Hormone Control of Implantation in the Mouse

Pituitary Hormone Control of Implantation in the Mouse

Effect of the fetal placenta and of a rabbit pituitary extract on plasma progesterone in fetectomized rabbits

Hormonal Changes During Formation and Involution of Corpus Luteum in Rabbits

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