Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F&lt;sub&gt;2&lt;/sub&gt; &lt;sub&gt;&amp;alpha;&lt;/sub&gt;, Progesterone and Noradrenaline

Skarżyński, Dariusz; Jaroszewski, Jerzy Jan; Okuda, Kiyoshi

doi:10.1262/jrd.47.125

Cited by 22 publications

(29 citation statements)

References 97 publications

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“…A recent study and a recent review demonstrate that P affects the functionality of the bovine early CL in an autocrine and paracrine manner (52,53). These actions do not seem to be reflected by expression levels of PR in our study.…”

Section: Discussioncontrasting

confidence: 62%

Expression of Estrogen and Progesterone Receptors in the Bovine Ovary During Estrous Cycle and Pregnancy

Berisha¹,

Pfaffl²,

Schams³

2002

ENDO

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Section: Discussioncontrasting

confidence: 62%

Expression of Estrogen and Progesterone Receptors in the Bovine Ovary During Estrous Cycle and Pregnancy

Berisha¹,

Pfaffl²,

Schams³

2002

ENDO

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“…Moreover, PGE2 secretion by the CL tissue was higher in the animals with gestageninduced estrus compared with the control and aPGF2α-synchronized animals. The high concentrations of basal-endogenous PGE2 production by the CL may be a reason for the lower reactions of the CL on exogenous treatment, as has been previously shown for exogenous PGF2α treatment in the bovine uterus [26] and CL [12,27]. In fact, a lower LH effect on PGE2 was found in the norgestomet-synchronized CL.…”

Section: Discusssionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

“…Arachidonic acid metabolites, such as PGE2 and PGI2, have been proposed to have multiple roles as luteotrophic, luteostatic or luteoprotective signals during the estrous cycle and pregnancy [8][9][10]. In fact, PG may regulate cell proliferation and differentiation and may stimulate P4 production regulating/stimulating CL formation, development and maintenance [7,11,12].In the absence of an embryo in the uterus, the process of CL regression begins on Days 17-19 of the estrous cycle in cows [13]. This process is characterized not only by functional but also structural changes that occur in the luteal steroidogenic and nonsteroidogenic cells [14].…”

mentioning

confidence: 99%

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<i>In Vitro</i> Assessment of Progesterone and Prostaglandin E<sub>2</sub> Production by the Corpus Luteum in Cattle Following Pharmacological Synchronization of Estrus

Skarzynski

Siemieniuch

Pilawski

et al. 2009

Journal of Reproduction and Development

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Abstract.We studied the secretory function of the corpus luteum (CL) in cows following different estrus synchronization protocols. Estrus was synchronized using one (n=4) or two injections (n=5) of prostaglandin F2α (PGF2α; dinoprost), two injections of different analogues of PGF2α (aPGF2α), luprostiol (n=5) and cloprostenol (n=5), at eleven-day intervals, a gestagen implant (norgestomet, n=5, for 10 days) or norgestomet together with a subsequent dinoprost injection on the day of implant removal (n=5). CL samples were collected by ovariectomy on Day 7-8 of the estrous cycle. Luteal strips were stimulated with LH (100 ng/ml) or prostaglandin E2 (PGE2, 10 -6 M) for 24 h in culture media. The progesterone (P4) and PGE2 concentrations in the media were measured by enzyme immunoassay. In the control CL (spontaneous estrus; n=5), LH and PGE2 stimulated P4 and PGE2 (P<0.001). The effects of both factors on P4 were reduced in the CL following dinoprost-and cloprostenol-synchronized estrus (P<0.05) and were absent in the luprostiol-synchronized CL (P>0.05). In the norgestomet-synchronized CL, the stimulatory effects of LH and PGE2 were higher compared with the CL synchronized by aPGF2α (P<0.05). Pharmacological manipulation of the estrous cycle using aPGF2α may cause lower P4 secretion. Estrus synchronization inhibited CL sensitivity to luteotropic factors. Therefore, attention should be focused on the estrous synchronization method in both in vivo and in vitro studies of CL functions in cattle. Key words: Cattle, Corpus luteum (CL), Estrus synchronization, Progesterone, Prostaglandin E2 (PGE2), Prostaglandin F2α (PGF2α) analogue (J. Reprod. Dev. 55: [170][171][172][173][174][175][176] 2009) he physiological processes of corpus luteum (CL) formation, growth and maintenance might be regulated by many different factors including luteinizing hormone (LH) and prostaglandin (PG)s [1,2]. After ovulation, as the CL forms from the wall of the ruptured follicle, it grows and rapidly vascularizes [3]. The CL is a complex tissue composed of parenchymal (steroidogenic) and nonparenchymal (fibroblast, vascular smooth muscle, pericyte and endothelial) cells [3,4]. Disturbances in physiological conditions and pharmacological manipulations during follicle growth and maturation, ovulation and as well during early CL formation influence the future secretory function of this new formed endocrine gland.The main function of the CL is secretion of progesterone (P4), an important hormone for the establishment and maintenance of a successful pregnancy [1,2,5]. In domestic animals, LH, which is released in a pulsatile fashion from the anterior pituitary, is one of the most potent regulators of P4 production [6]. LH stimulates basal P4 production in small luteal cells via the LH receptor. In addition to pituitary LH, intraluteal substances produced by the component cells of the CL play important roles in regulating P4 production during the luteal stages and pregnancy [1,2,7]. Arachidonic acid metabolites, such as PGE2 and PGI2, have been prop...

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“…Continued CL growth is stimulated by autocrine and paracrine mechanisms [68]. The CL develops within 2-3 days after ovulation, grows until a maximum diameter of about 30 mm, and starts to regress at day 17-18 of the cycle [50,73], although P4 levels may start to decline earlier [81].…”

Section: Corpus Luteummentioning

confidence: 99%

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Bôer

Stötzel

Röblitz

et al. 2011

Journal of Theoretical Biology

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Bovine fertility is the subject of extensive research in animal sciences, especially because fertility of dairy cows has declined during the last decades. The regulation of estrus is controlled by the complex interplay of various organs and hormones. Mathematical modeling of the bovine estrous cycle could help in understanding the dynamics of this complex biological system. In this paper we present a mechanistic mathematical model of the bovine estrous cycle that includes the processes of follicle and corpus luteum development and the key hormones that interact to control these processes. The model generates successive estrous cycles of 21 days, with three waves of follicle growth per cycle. The model contains 12 differential equations and 54 parameters. Focus in this paper is on development of the model, but also some simulation results are presented, showing that a set of equations and parameters is obtained that describes the system consistent with empirical knowledge. Even though the majority of the mechanisms that are included in the model are based on relations that in literature have only been described qualitatively (i.e. stimulation and inhibition), the output of the model is surprisingly well in line with empirical data. This model of the bovine estrous cycle could be used as a basis for more elaborate models with the ability to study effects of external manipulations and genetic differences. AMS MSC 2000: 92C42, 92C30, 90C31, 65L09

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Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>α</sub>, Progesterone and Noradrenaline

Cited by 22 publications

References 97 publications

Expression of Estrogen and Progesterone Receptors in the Bovine Ovary During Estrous Cycle and Pregnancy

Expression of Estrogen and Progesterone Receptors in the Bovine Ovary During Estrous Cycle and Pregnancy

<i>In Vitro</i> Assessment of Progesterone and Prostaglandin E<sub>2</sub> Production by the Corpus Luteum in Cattle Following Pharmacological Synchronization of Estrus

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

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