Luxury of N‐Tosylhydrazones in Transition‐Metal‐Free Transformations

Abstract

Scheme 12. Three-component reactiono fa-halo-N-tosylhydrazones,indoles and arylboronic acids.Scheme 13. Total synthesis of avrainvilleol.Scheme14. Synthesis of dienes from allenylboronic acids.Scheme 55. ClassicF ischer indole reaction with N-tosylhydrazones.Scheme56. Synthesis of 1H-indazoles via ab enzyne intermediate.Scheme57. Proposed mechanism for the synthesis of 1H-indazoles.

Iron catalysts with N-ligands for carbene transfer of diazo reagents

“…The present review furnishes a comprehensive picture of the most relevant catalytic applications of iron catalysts to carbene transfer reactions of diazo reagents under homogeneous conditions. Considering that the review is focused on the activity of iron catalysts, carbene transfer reactions by metalfree activation of diazo species 14 and diazo precursors 15 will not be addressed here. It should be noted that the activity of artificial iron biocatalysts, obtained by conjugation of iron porphyrinoid units with biological scaffolds, will also be reported briefly in order to underline similarities and differences between reaction mechanisms mediated by modified biocatalysts and synthetic catalysts.…”

Aryl‐Diadamantyl Phosphine Ligands in Palladium‐Catalyzed Cross‐Coupling Reactions: Synthesis, Structural Analysis, and Application

“…In parallel with the study of the Buchwald‐Hartwig amination reaction, we examined the applicability of the ligands in the coupling reactions of ortho ‐substituted aryl halides and tosylhydrazones, which are versatile reagents for synthetic transformations . These are the key reagents for producing alkene derivatives in Bamford‐Stevens and in Shapiro reactions.…”

“…Moreover, the application of tosylhydrazones in palladium‐catalyzed cross‐coupling reactions opened a new synthetic possibility for the synthesis of arylalkene derivatives. [24b]…”

Novel 2,4,6-Trimethylbenzenesulfonyl Hydrazones with Antibacterial Activity: Synthesis and In Vitro Study

“…One class of compounds that has attracted the attention of scientists in recent years is benzenesulfonohydrazide derivatives. This interest results from the possibility of their wide use in chemical synthesis as intermediates [ 4 , 5 , 6 , 7 ], as well as the fact that this group of compounds has significant and wide spectrum of biological properties, including anticancer [ 8 , 9 , 10 , 11 , 12 ], antibacterial [ 13 , 14 , 15 , 16 , 17 ], antifungal [ 14 , 18 , 19 , 20 , 21 ], and antidepressant activity [ 22 , 23 ].…”