With the continuing global pandemic of coronavirus (COVID-19) sickness, it is critical to seek diagnostic approaches that are both effective and rapid to limit the number of people infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The results of recent research suggest that radiological images include important information related to COVID-19 and other chest diseases. As a result, the use of deep learning (DL) to assist in the automated diagnosis of chest diseases may prove useful as a diagnostic tool in the future. In this study, we propose a novel fusion model of hand-crafted features with deep convolutional neural networks (DCNNs) for classifying ten different chest diseases such as COVID-19, lung cancer (LC), atelectasis (ATE), consolidation lung (COL), tuberculosis (TB), pneumothorax (PNET), edema (EDE), pneumonia (PNEU), pleural thickening (PLT), and normal using chest X-rays (CXR). The method that has been suggested is split down into three distinct parts. The first step involves utilizing the Info-MGAN network to perform segmentation on the raw CXR data to construct lung images of ten different chest diseases. In the second step, the segmented lung images are fed into a novel pipeline that extracts discriminatory features by using hand-crafted techniques such as SURF and ORB, and then these extracted features are fused to the trained DCNNs. At last, various machine learning (ML) models have been used as the last layer of the DCNN models for the classification of chest diseases. Comparison is made between the performance of various proposed architectures for classification, all of which integrate DCNNs, key point extraction methods, and ML models. We were able to attain a classification accuracy of 98.20% for testing by utilizing the VGG-19 model with a softmax layer in conjunction with the ORB technique. Screening for COVID-19 and other lung ailments can be accomplished using the method that has been proposed. The robustness of the model was further confirmed by statistical analyses of the datasets using McNemar's and ANOVA tests respectively.