Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo

Lx2-32c, a Novel Taxane Derivative, Exerts Anti-resistance Activity by Initiating Intrinsic Apoptosis Pathway <i>in Vitro</i> and Inhibits the Growth of Resistant Tumor <i>in Vivo</i>

“…Our previous study suggested that Lx2-32c could restrain the growth of some drug-resistant cancer cells by MTT assay. 15) For further research, this paper aimed to evaluate the anti-drug-resistance activity of Lx2-32c on paclitaxel-resistant models, in vitro and in vivo. To ensure that results would not be affected by different experimental conditions or different operators, we reconfirmed the cytotoxicity of Lx2-32c to 6 pairs of drug-resistant cell lines and their related sensitive cell lines, in contrast to paclitaxel, by MTT assay.…”

“…What is more, it restrained the growth of some drug-resistant cancer cells. 15) For further research, this paper aimed to evaluate the anti-resistance activity of Lx2-32c on paclitaxelresistant models, in vitro and in vivo. Our data demonstrated the excellent efficacy of Lx2-32c in overcoming paclitaxel resistance.…”

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

“…16 and 17; however, they are in conformity with previous reports indicating that different cell lines exhibited diverse susceptibility to the same chemical constitution. 28,29) IcaS treatment of MCF7 cells induced apoptosis DAPI staining, PI staining and annexin V-FITC apoptosis detection…”

Five new triterpenoid saponins from the Roots of Camellia oleifera C. Abel with cytotoxic activities

“…The viability of the cells after treated with the isolated saponins against A549, SMCC-7721 and MCF-7 human tumor cell lines (Cell Bank, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences) was evaluated using the MTT assay performed as previously reported (Wang et al, 2008). Cells were plated into 96-well flat-bottomed cultured plates at a concentration of 1 Â10 5 cells per well in fresh culture medium.…”