Lxxii. Pityrosporum Ovale (Bottle Bacillus of Unna, Spore of Malassez)

Moore, Morris

doi:10.1001/archderm.1936.01470090047004

Cited by 34 publications

(4 citation statements)

References 7 publications

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“…study of 139 patients with dandruff. 6 During an eight-week treatment period, an analysis of the most severe patients showed that ketoconazole was significantly better than placebo and zinc pyrithione (p < 0.05) at Weeks 6 and 8 (Figure 3). weeks.…”

Section: Ketoconazole Vs Zinc Pyrithionementioning

confidence: 96%

“…Unna, and later Sabouraud, subsequently confirmed these observations and the aetiological agent was identified as Pityrosporum ovale. 3 , 4 Evidence supporting the Pityrosporum hypothesis continued to accumulate until well into the 1930s 5 , 6 . However, the hypothesis failed to gain acceptance at that time for several reasons, including the lack of an effective treatment 7 …”

Section: Introductionmentioning

confidence: 99%

“…5 . 6 However, the hypothesis failed to gain acceptance at that time for several reasons, including the lack of an effective treatment. 7 The advent of corticosteroids after World War II and their use in seborrhoeic dermatitis to moderate effect led to the c1assification of the disease as an eczematous disorder.…”

Section: Introductionmentioning

confidence: 99%

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An Overview of Experience With Ketoconazole Shampoo

Ive

1991

Int J Clinical Practice

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The spectrum of disease known as dandruff/seborrhoeic dermatitis has been shown to be due to infection of the skin by the Pityrosporon species of fungus. Ketoconazole shampoo has been shown to suppress effectively both the organism's growth and the symptoms and signs of the clinical disorder.Dandruff and seborrhoeic dermatitis are different expressions of the same disease spectrum. Dandruff is characterised by white, dry, loose scaling and mild pruritus of the scalp. These symptoms can occur in isolation or together. Seborrhoeic dermatitis can be defined as an acute, subacute or chronic scaly disease affecting the areas of sebaceous activity. It can affect the scalp, hairline and forehead; the face, in particular the nasolabial folds, and hair-bearing areas; the sternum and interscapular regions, and the retroauricular area and external ear canal. The most frequent symptom is scaling, which may be dry, grey and flaky or yellowish and greasy; it is also often associated with pruritus and erythema. Over-production of sebum does not occur. On the scalp seborrhoeic dermatitis is characterised by diffuse, yellowish, greasy scales, which may form crusts and extend to the hairline and forehead. It is simply a severe form of dandruff and, as such, has proved until recently a difficult disorder to treat. Increasing evidence as to the cause of this spectrum has, however, improved the outlook for all cases.

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Section: Ketoconazole Vs Zinc Pyrithionementioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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An Overview of Experience With Ketoconazole Shampoo

Ive

1991

Int J Clinical Practice

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“…The strain isolated by Moore (9,10) and used in inoculation experiments to prove the pathogenicity of P. ovale grows readily and quickly on such media. Ota and Huang state that strains isolated by Acton and Panja and by Castellani (3) were essentially like their own.…”

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confidence: 99%