LXXVI.—The colouring principle contained in the bark of Myrica nagi. Part I

Perkin, Arthur George; Hummel, J. J.

doi:10.1039/ct8966901287

Cited by 29 publications

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“…Myricetin was first isolated in India from the bark of Myrica nagi Thunb. (Myricaceae) as light yellow-coloured crystals [36]. The compound is recognised mainly for its iron-chelating, anticancer, antioxidant, anti-inflammatory and antidiabetic activities among others [34,37].…”

Section: Discussionmentioning

confidence: 99%

Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice

et al. 2020

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This study investigated the leaves of Clinacanthus nutans for its bioactive compounds and acute and subacute toxicity effects of C. nutans ethanolic leaf extract (CELE) on blood, liver and kidneys of ICR mice. A total of 10 8-week-old female mice were divided into groups A (control) and B (2000 mg/kg) for the acute toxicity study. A single dose of 2000 mg/kg was administered to group B through oral gavage and mice were monitored for 14 days. In the subacute toxicity study, mice were divided into five groups: A (control), B (125 mg/kg), C (250 mg/kg), D (500 mg/kg) and E (1000 mg/kg). The extract was administered daily for 28 days via oral gavage. The mice were sacrificed, and samples were collected for analyses. Myricetin, orientin, isoorientin, vitexin, isovitexin, isookanin, apigenin and ferulic acid were identified in the extract. Twenty-eight days of continuous oral administration revealed significant increases (p < 0.05) in creatinine, ALT and moderate hepatic and renal necrosis in groups D and E. The study concluded that the lethal dose (LD50) of CELE in mice is greater than 2000 mg/kg and that repeated oral administrations of CELE for 28 days induced hepatic and renal toxicities at 1000 mg/kg in female ICR mice.

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Section: Discussionmentioning

confidence: 99%

Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice

et al. 2020

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“…It was first isolated in the late eighteenth century from the bark of Myrica nagi Thunb. (Myricaceae), harvested in India, as light yellow-coloured crystals [ 10 ]. Isolation was primarily sparked by interest in the dyeing property of the compound.…”

Section: Introductionmentioning

confidence: 99%

Myricetin: A Dietary Molecule with Diverse Biological Activities

et al. 2016

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Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. It displays several activities that are related to the central nervous system and numerous studies have suggested that the compound may be beneficial to protect against diseases such as Parkinson’s and Alzheimer’s. The use of myricetin as a preserving agent to extend the shelf life of foods containing oils and fats is attributed to the compound’s ability to protect lipids against oxidation. A detailed search of existing literature revealed that there is currently no comprehensive review available on this important molecule. Hence, the present work includes the history, synthesis, pharmaceutical applications and toxicity studies of myricetin. This report also highlights structure-activity relationships and mechanisms of action for various biological activities.

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“…Myricetin (3,5,7,3 ,4 ,5 -hexahydroxyflavone cannabiscetin) is a bioflavonoid (Figure 4) widely found in food sources such as vegetables, tea, berries, red wine and medicinal plants. It was first isolated from the bark of the Myrica nagi Thunb, Myricaceae in 1896 with molecular formulae of C 15 H 10 O 8 [86]. Myricetin has been credited for its therapeutic effects in cardiovascular disease [87], cancer [88], and diabetes mellitus [89,90].…”

Section: Myricetinmentioning

confidence: 99%

Bioactive Compounds: Natural Defense Against Cancer?

2019

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Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from plants are gaining wide attention for their anticancer activities. Several studies have found that natural plant-based bioactive compounds can enhance the efficacy of chemotherapy, and in some cases ameliorate some of the side-effects of drugs used as chemotherapeutic agents. In this paper, we have reviewed the literature on the anticancer effects of four plant-based bioactive compounds namely, curcumin, myricetin, geraniin and tocotrienols (T3) to provide an overview on some of the key findings that are related to this effect. The molecular mechanisms through which the active compounds may exert their anticancer properties in cell and animal-based studies also discussed.

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LXXVI.—The colouring principle contained in the bark of Myrica nagi. Part I

Abstract: Y o r kshire College. resorcinol group, and its distinctive dyeing properties wlicn compared with the above three colouring motters must be due t o this fact.

Cited by 29 publications

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Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice

Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice

Myricetin: A Dietary Molecule with Diverse Biological Activities

Bioactive Compounds: Natural Defense Against Cancer?

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