The behavior of the analytical solutions of the fractional differential equation described by the fractional order derivative operators is the main subject in many stability problems. In this paper, we present a new stability notion of the fractional differential equations with exogenous input. Motivated by the success of the applications of the Mittag-Leffler functions in many areas of science and engineering, we present our work here. Applications of Mittag-Leffler functions in certain areas of physical and applied sciences are also very common. During the last two decades, this class of functions has come into prominence after about nine decades of its discovery by a Swedish Mathematician Mittag-Leffler, due to the vast potential of its applications in solving the problems of physical, biological, engineering, and earth sciences, to name just a few. Moreover, we propose the generalized Mittag-Leffler input stability conditions. The left generalized fractional differential equation has been used to help create this new notion. We investigate in depth here the Lyapunov characterizations of the generalized Mittag-Leffler input stability of the fractional differential equation with input.