Lychnophora ericoides Mart. (Brazilian arnica) ethanol extract accelerates the skin wound healing process: Evidence for its mechanism of action

Marinho, Bárbhara Mota; Guimarães, Victor Hugo Dantas; Moraes, D.; Ribeiro, Guilherme Henrique Mendes; Silva, Rodrigo Moreira da; Lopes, Norberto Peporine; Guimarães, André Luiz Sena; De-Paula, Alfredo Maurício Batista; Santos, Sérgio Henrique Sousa

doi:10.1016/j.phymed.2023.155000

Cited by 2 publications

References 36 publications

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Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Lopes,

Kato,

Buqui

et al. 2024

Rev. Bras. Farmacogn.

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Species of Lychnophora, popularly known in Brazil as "Arnica-da-serra", are widely used in topical preparations as analgesics and anti-in ammatories. The most commonly used species is Lychnophora ericoides, and studies of seasonal and circadian rhythms show greater stability for phenolic constituents than for sesquiterpene lactones (an opposite behavior was observed). These lactones are considered defensive substances; thus, they were found in signi cant quantities in border regions between two biomes, at least for L. ericoides. Herbalists often report that seasonality in uences on the increase of lactone levels in leaves and may have increase the allergenic potential. In the present study, we sought to develop a methodology for imaging tissues treated with solutions of the sesquiterpene lactone goyazensolide to observe skin retention using the Franz cell model. To this end, MALDI-MS parameters were optimized for imaging generation, and an LC-MS/MS protocol was used to con rm goyazensolide skin retention. The obtained data revealed that sesquiterpene lactones strongly bind to the skin structure.

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Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Lopes,

Kato,

Buqui

et al. 2024

Rev. Bras. Farmacogn.

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show abstract

Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Lopes,

Kato,

Buqui

et al. 2024

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Species of Lychnophora, popularly known in Brazil as "Arnica-da-serra", are widely used in topical preparations as analgesics and anti-inflammatories. The most commonly used species is Lychnophora ericoides, and studies of seasonal and circadian rhythms show greater stability for phenolic constituents than for sesquiterpene lactones (an opposite behavior was observed). These lactones are considered defensive substances; thus, they were found in significant quantities in border regions between two biomes, at least for L. ericoides. Herbalists often report that seasonality influences on the increase of lactone levels in leaves and may have increase the allergenic potential. In the present study, we sought to develop a methodology for imaging tissues treated with solutions of the sesquiterpene lactone goyazensolide to observe skin retention using the Franz cell model. To this end, MALDI-MS parameters were optimized for imaging generation, and an LC-MS/MS protocol was used to confirm goyazensolide skin retention. The obtained data revealed that sesquiterpene lactones strongly bind to the skin structure.

show abstract

Lychnophora ericoides Mart. (Brazilian arnica) ethanol extract accelerates the skin wound healing process: Evidence for its mechanism of action

Cited by 2 publications

References 36 publications

Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

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