Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition

Zhao, Xin; Guo, Sheng; Lu, You-Yuan; Yang, Hua; Zhang, Fang; Yan, Hui; Shang, Erxin; Wang, Hanqing; Zhang, Wenhua; Duan, Jin‐Ao

doi:10.1016/j.biopha.2019.109559

Cited by 77 publications

(49 citation statements)

References 42 publications

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“…The metabolism of nicotinic acid and nicotinamide was also related to the occurrence of T2DM and in ammatory response [35,36]. Our results showed that the abovementioned related pathways could be regulated by CAP and MET co-treatment [37]. Compared with MET monotherapy, the combination therapy could signi cantly reduce the microbial metabolism of histidine, which was associated with T2DM.…”

Section: Discussionmentioning

confidence: 75%

Capsaicin Improves The Hypoglycemic Effect of Metformin Benefitted From Gut Microbiota

Kang¹,

Hu²,

Chen³

et al. 2021

Preprint

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Background: Capsaicin(CAP) possesses a hypoglycemic activity through remodulating gut microbiota as well as the first-line oral hypoglycemic drug, metformin(MET). However, CAP on the hypoglycemic effect of MET pertinent to gut microbiota remained poorly known.Methods: The glucose and insulin tolerance of diabetic rats were monitored. The glycolipid metabolism were analyzed by detecting blood biochemical parameters. Liver pathological changes were observed by HE staining. The inflammatory cytokines and intestinal tight junction proteins were detected by RT-PCR and Western blot. 16S rRNA sequencing was employed to analyze gut microbiota.Results: Compared with MET monotherapy, CAP and MET co-treatment could significantly reduce fasting blood glucose, improve glucose tolerance, lessen the degree of liver injury and inflammatory infiltration, reduce the expression of inflammatory cytokines and increase the expression of intestinal tight junction proteins in diabetic rats. Moreover, CAP and MET co-treatment altered gut microbiota profiles by regulating microbial abundances such as Akkermansia.Conclusion: CAP showed significant hypoglycemic effect of MET benefitted from remodulating gut microbiota in diabetic rats.

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Section: Discussionmentioning

confidence: 75%

Capsaicin Improves The Hypoglycemic Effect of Metformin Benefitted From Gut Microbiota

Kang¹,

Hu²,

Chen³

et al. 2021

Preprint

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“…Recently, the role of the gut-brain axis in the management of many diseases has been the focus of much research activity. However, although a few studies reported the effect of plant extracts on microbiota (not gut-brain axis) in the diabetic animal model (15) , the anti-diabetic effects of plant extracts based on the gut-brain axis were rarely explored. Duca et al (16) indicated that the widely used drug metformin was shown to suppress glucose production through the gut-brain axis.…”

Section: Discussionmentioning

confidence: 99%

Glucose-lowering activity of dark tea protein extract by modulating spleen–brain axis of diabetic mice

Mao

Zhang

2020

Br J Nutr

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The present study aims to explore the glucose-lowering effects of the previously characterised dark tea (Camellia sinensis L.) protein extract (DTPE) from Heimaojian on the spleen–brain axis of diabetic mice. DTPE was orally administrated (50–100 mg/kg) to alloxan-induced mice for 21 d; a biochemical assay and transcriptome profiling (RNA sequencing (RNA-Seq)) were performed. The results showed that DTPE can improve glucose tolerance. Compared with the model group, at day 21, the fasting blood glucose values were significantly (P < 0·05) decreased by 44·9 % (13·8 v. 7·6 mmol/l) and 51·4 % (13·8 v. 6·7 mmol/l) for high dose of DTPE (100 mg/kg) and drug metformin (125 mg/kg) groups, respectively. Subsequently, transcriptome profiling (RNA-Seq) was performed on the spleen and brain of diabetic mice. Totally, fifty-two spleen-derived and forty-seven brain-derived differentially expressed genes related to the synthesis, transport and metabolism of glucose were identified. The regulatory network analysis indicated that DTPE may exert glucose-lowering effects through a thirty-seven-gene sub-network related to metabolism, Parkinson’s disease, oxidative phosphorylation and immunity. In summary, for the first time, the present data revealed that dark tea-derived DTPE could exert a potential anti-hyperglycaemic effect by modulating the spleen–brain axis.

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“…According to the reference ( Zhao et al, 2020 ), the intestinal flora diversity was sequenced and analyzed. The total microbial DNA was extracted from fresh fecal samples using the E. Z.N.A.…”

Section: Methodsmentioning

confidence: 99%

Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou Seed Ameliorates Insomnia in Rats by Regulating Metabolomics and Intestinal Flora Composition

et al. 2021

Self Cite

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The seed of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou (ZSS) is often used as a traditional Chinese medicine for insomnia due to its sedative and hypnotic effects, but the mechanism underlying this effect has not been thoroughly elucidated. In this study, an insomnia model induced by intraperitoneal injection of DL-4-chlorophenylalanine suspension in Sprague-Dawley rats was adopted to investigate the therapeutic effect of ZSS extract. Metabolomics analyses of plasma and urine as well as 16S rRNA gene sequencing of the intestinal flora were performed. The relationships between the plasma and urine metabolites and the intestinal flora in insomnia rats were also analyzed. The results showed that changes in plasma and urine metabolites caused by insomnia were reversed after administration of ZSS, and these changes were mainly related to amino acid metabolism, especially phenylalanine metabolism. The results of 16S rRNA gene sequencing and short-chain fatty acid determination showed that the ZSS extract could reverse the imbalance of intestinal flora caused by insomnia and increase the contents of SCFAs in feces. All of these improvements are mainly related to the regulation of inflammation. Therefore, it is concluded that insomnia, which alters metabolic profiles and the intestinal flora, could be alleviated effectively by ZSS extract.

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Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition

Cited by 77 publications

References 42 publications

Capsaicin Improves The Hypoglycemic Effect of Metformin Benefitted From Gut Microbiota

Capsaicin Improves The Hypoglycemic Effect of Metformin Benefitted From Gut Microbiota

Glucose-lowering activity of dark tea protein extract by modulating spleen–brain axis of diabetic mice

Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou Seed Ameliorates Insomnia in Rats by Regulating Metabolomics and Intestinal Flora Composition

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