Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway

Zhu, Shi-Yong; Guo, Jianying; Li, Jinyang; Dai, Xueyan; Li, Xue-Nan; Li, Jinlong

doi:10.1039/d1fo02857j

Cited by 40 publications

(28 citation statements)

References 61 publications

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“…This suggested that ATZ could induce inflammation in mice, which was consistent with the previous study. 4 The concentrations of TNF-α, IL-6 and IL-10 in both ATZ1 + L and ATZ2 + L were not different from the control group. It seemed that Lyc ameliorated ATZ-induced inflammation.…”

Section: Papermentioning

confidence: 80%

“…ATZ can induce pyroptosis in splenocytes via the Ox-mtDNA/Nlrp3 inflammasome pathway. 4 Additionally, our previous study has provided evidence that ATZ also induced apoptosis in B cell zones by inhibiting the expression of Foxo1 (the data are not shown). The dysregulation of B cells contributes to immunodeficiency.…”

Section: Introductionmentioning

confidence: 89%

“…4-Week-old mice (ICR, SPF Grade, male) were randomly divided into several groups, and drug treatment was carried out according to the previous study. 4 The detailed experimental grouping and treatment are shown in Table S1, ESI. †…”

Section: Animal Care and The Experimental Designmentioning

confidence: 99%

“…DHE staining was performed according to the previous study. 4 Fluorescence microscopy images were obtained using a DMi8 (Leica, Wetzlar, Germany).…”

Section: Histological Analysismentioning

confidence: 99%

“…[18][19][20] Previous studies indicated that Lyc consumption protected the spleen, heart and kidney from ATZ exposure due to its antioxidant properties. 4,18 However, the protective role of Lyc in ameliorating ATZ-induced thymic injury is unclear.…”

Section: Introductionmentioning

confidence: 99%

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IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Zhu

Tong

et al. 2022

Food Funct.

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Section: Papermentioning

confidence: 80%

Section: Introductionmentioning

confidence: 89%

Section: Animal Care and The Experimental Designmentioning

confidence: 99%

“…DHE staining was performed according to the previous study. 4 Fluorescence microscopy images were obtained using a DMi8 (Leica, Wetzlar, Germany).…”

Section: Histological Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Zhu

Tong

et al. 2022

Food Funct.

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Resveratrol protects against cadmium‐induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes

Zhang

et al. 2023

J Sci Food Agric

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BACKGROUND Cadmium (Cd), known as a vital contaminant in the environment, penetrates the blood–brain barrier and accumulates in the cerebrum. Acute toxicosis of Cd, which leads to lethal cerebral edema, intracellular accumulation and cellular dysfunction, remains to be illuminated with regard to the exact molecular mechanism of cerebral toxicity. Resveratrol (RES), present in the edible portions of numerous plants, is a simply acquirable and correspondingly less toxic natural compound with neuroprotective potential, which provides some theoretical bases for antagonizing Cd‐induced cerebral toxicity. RESULTS This work was executed to research the protective effects of RES against Cd‐induced toxicity in chicken cerebrum. Markedly, these lesions were increased in the Cd group, which also exhibited a thinner cortex, reduced granule cells, vacuolar degeneration, and an enlarged medullary space in the cerebrum. Furthermore, Cd induced CYP450 enzyme metabolism disorders by disrupting the nuclear xenobiotic receptor response (NXRs), enabling the cerebrum to reduce the ability to metabolize exogenous substances, eventually leading to Cd accumulation. Meanwhile, accumulated Cd promoted oxidative damage and synergistically promoted the damage to neurons and glial cells. CONCLUSION RES initiated NXRs (especially for aromatic receptor and pregnancy alkane X receptor), decreasing the expression of CYP450 genes, changing the content of CYP450, maintaining CYP450 enzyme normal activities, and exerting antagonistic action against the Cd‐induced abnormal response of nuclear receptors. These results suggest that the cerebrum toxicity caused by Cd was reduced by pretreatment with RES. © 2023 Society of Chemical Industry.

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Cerebellar injury induced by cadmium via disrupting the heat-shock response

Talukder

Sun

et al. 2022

Environ Sci Pollut Res

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Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway

Abstract: Nlrp3 is a vital integration point of diverse extracellular stimuli and cellular stress. However, inappropriate activation of Nlrp3 results in progression of autoinflammatory and metabolic disorders. Atrazine, using widely in...

Cited by 40 publications

References 61 publications

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Resveratrol protects against cadmium‐induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes

Cerebellar injury induced by cadmium via disrupting the heat-shock response

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