Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1

Li, Jing; Zeng, Xin; Yang, Xiao‐Long; Ding, Hong

doi:10.1039/d2fo01111e

Cited by 10 publications

(6 citation statements)

References 49 publications

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“… 36 The microvasculature is responsible for delivering oxygen and epidermal cells, thus determining the cell environment and papillae. 37 , 38 Subcutaneous fat also needs adequate support of the capillaries. Loss of subcutaneous fat generally causes skin swelling and contraction.…”

Section: Discussionmentioning

confidence: 99%

Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

Zhang,

Li,

Geng

et al. 2024

CCID

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Purpose Previous studies have suggested a relationship between autoimmune diseases and the risk of facial skin aging. However, evidence from population-based studies on this topic is limited, leaving the causal association between these factors unknown. This study aimed to systematically evaluate the causal effects of 18 autoimmune diseases on the risk of facial skin aging, aim of providing strategies to mitigate early facial aging in patients with autoimmune diseases. Patients and Methods We conducted univariate Mendelian randomization (UVMR) analyses to examine the causal relationship between 18 autoimmune diseases and facial aging using publicly available summary data from genome-wide association studies (GWASs). We also conducted multivariate Mendelian randomization (MVMR) analyses to adjust for confounding factors, including smoking, alcohol consumption, and body mass index (BMI). Results The main inverse variance weighted (IVW) method revealed that genetically proxied ankylosing spondylitis (AS) (OR 1.017; 95% CI: 1.003–1.031; P =0.018), sicca syndrome (SS) (OR 1.008; 95% CI: 1.005–1.011; P = 2.66×10 −6 ), systemic lupus erythematosus (SLE) (OR 1.006; 95% 1.001–1.011; P =0.014), multiple sclerosis (MS) (OR 1.004; 95% CI: 1.001–1.007; P =0.021), primary sclerosing cholangitis (PSC) (OR 1.002; 95% CI: 1.000–1.004; P =0.023), and celiac disease (CeD) (OR 1.002; 95% CI: 1.001–1.004; P =0.009) were significantly associated with higher risk of facial aging. After adjusting for potential confounding factors, the association persisted between AS, SLE, and CeD. Conclusion These findings indicated that autoimmune diseases play a causal role in facial skin aging. Therefore, patients with autoimmune diseases should take appropriate measures to prevent early facial aging.

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Section: Discussionmentioning

confidence: 99%

Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

Zhang,

Li,

Geng

et al. 2024

CCID

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“…Recently, there have been multiple publications related to other skin pathologies in which sirtuin alteration may have clinically relevant dermatological applications ( 146 – 152 ). For example, resveratrol and its analogs resveratryl triacetate (RTA) and resveratryl triglycolate (RTG) have been tested in multiple clinical studies.…”

Section: Wound Healingmentioning

confidence: 99%

The role of sirtuins in dermal fibroblast function

et al. 2023

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The sirtuins are a family of seven proteins that perform a variety of dermatological functions and help maintain both the structure and function of the skin. More specifically, the sirtuins have been shown to be altered in multiple dermal cell types including dermal fibroblasts. The functions of dermal fibroblasts are extensive, and include playing a significant role in wound healing as well as helping to maintain the integrity of the skin. As dermal fibroblasts age, they can undergo a state of permanent cell cycle arrest, known as cellular senescence. This senescent process can occur as a result of various stressors, including oxidative stress, ultraviolet radiation -induced stress, and replicative stress. In recent years, there has been a growing interest in both enhancing the cutaneous fibroblast’s ability to facilitate wound healing and altering fibroblast cellular senescence. Thus, in this review, we examine the relationship between sirtuin signaling and dermal fibroblasts to understand how this family of proteins may modulate skin conditions ranging from the wound healing process to photocarcinogenesis associated with fibroblast senescence. Additionally, we offer supporting data from experiments examining the relationship between fibroblast senescence and sirtuin levels in an oxidative stress model indicating that senescent dermal fibroblasts exhibit diminished sirtuin levels. Furthermore, we survey the research on the role of sirtuins in specific dermatological disease states that where dermal fibroblast function has been implicated. Finally, we conclude with outlining potential clinical applications of sirtuins in dermatology. In sum, we find that the literature on the involvement of sirtuins in dermal fibroblasts is limited, with research still in its early stages. Nevertheless, intriguing preliminary findings merit additional investigation into the clinical implications of sirtuins in dermatology.

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“…Dane dotyczące ekspresji białek szlaku insuliny, VEGF (czynnik wzrostu śródbłonka naczyniowego, ang. vascular endothelial growth factor) oraz sitruiny SIRT1 wykazały, że likopen może odwracać insulinooporność podczas procesu starzenia się skóry i promować neowaskularyzację mikronaczyniową w celu ochrony starzejącej się skóry [74].…”

Section: Wprowadzenieunclassified

Likopen – wpływ suplementacji na proces starzenia się skóry

2023

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Na proces starzenia się skóry wpływa mnóstwo różnych czynników (m.in. ekspozycja na słońce, palenie tytoniu, nieprawidłowe odżywianie), a ogromne znaczenie mają reaktywne formy tlenu (RFT). Skóra pod ich wpływem staje się słabsza, uszkodzeniom ulegają głównie włókna elastynowe i kolagenowe. Zmniejsza się też ilość lipidów, prowadząc do obumierania komórek skóry. Obecność wolnych rodników blokuje także naturalną zdolność naskórka do regeneracji. Każdy z tych czynników decyduje o przyspieszeniu wystąpienia oznak starzenia. Do pewnego stopnia z wolnymi rodnikami jest w stanie sobie poradzić nasz organizm poprzez wytwarzanie antyoksydantów. Z kolei, korzystnym rozwiązaniem jest także regularna suplementacja. Likopen jest czerwonym pigmentem, naturalnie występującym w pomidorach i jest znanym antyoksydantem. Wśród karotenoidów jest najsilniejszym wygaszaczem tlenu singletowego i zmiataczem rodników nadtlenowych, dzięki czemu stanowi ważny mechanizm obronny w ludzkim organizmie. Celem niniejszej pracy jest przedstawienie biologicznych właściwości likopenu w relacji do jego korzystnego wpływu na procesy starzenia się skóry.

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Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1

Abstract: Microvascular loss is one of the most important characteristics of skin aging, and abundant microvascular plays a key role in preserving skin health. Given the involvement of lycopene (Ly) in...

Cited by 10 publications

References 49 publications

Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

The role of sirtuins in dermal fibroblast function

Likopen – wpływ suplementacji na proces starzenia się skóry

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