Lycopene and Vascular Health

Mozoş, Ioana; Stoian, Dana; Caraba, Alexandru; Malainer, Clemens; Horbańczuk, J.O.; Atanasov, Atanas G.

doi:10.3389/fphar.2018.00521

Cited by 152 publications

(101 citation statements)

References 135 publications

(252 reference statements)

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“…There are also other promising predictors of cardiovascular events, which were not assessed in this study: Arterial stiffness and early arterial aging, known to be associated with interleukins and inflammatory markers [59]. Moreover, a healthy diet, especially the inclusion of sufficient fruits and vegetables in the diet, is regarded as significantly important and may exert several cardioprotective effects [60].…”

Section: Discussionmentioning

confidence: 92%

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

et al. 2019

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Background: Over the last two decades, many studies have investigated the association between interleukin 6 (IL-6) and pathogenesis and progression of coronary artery disease (CAD). Patients with CAD manifested at a young age are a particularly interesting group. They differ from older patients, not only in terms of the severity of coronary artery atherosclerosis, but also risk factor profiles, short- and long-term prognosis after myocardial infarction (MI). The role of IL-6 in younger patients with CAD is less well-known. Therefore, our study aimed to analyze the relationship between IL-6 level and other inflammations, atherosclerosis, and cardiac function parameters in early onset CAD patients. Methods: The study covered 100 patients with early onset CAD and a group of 50 healthy participants. Plasma levels of IL-6 and basic biochemical parameters, anthropometric, echocardiographic, and arteries Doppler ultrasound measurements were performed. Results: We did not observe a significant difference in IL-6 concentration in plasma between patients with early onset CAD and a control group, but IL-6 level was negatively correlated with echocardiographic measurements of ascending aorta diameter, left ventricular shortening fraction, and right ventricular end-diastolic diameter in our patients. Conclusions: In patients with early onset CAD, plasma IL-6 level is associated with other inflammation parameters and with cardiac function, potentially contributing to right ventricular remodeling and left ventricular systolic dysfunction. This suggests possible prognostic benefits of long-time observation of IL-6 level after the acute coronary syndrome.

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Section: Discussionmentioning

confidence: 92%

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

et al. 2019

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“…The main phytochemical constituents of Lycopersicon esculentum include flavonoids (kaempferol, quercetin, rutin and naringenin), caretone (lycopene) and other compounds like caffeic, chlorogenic, ferulic and p-coumaric acids [37,38]. These compounds have shown their effects as antioxidant and antiplatelet [39,40] obtained from other plants so there is possibility that the antioxidant and antiplatelet activities of Lycopersicon esculentum may be due the presence of these constituents.…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet and Antioxidant Activities of Tomato

Khan¹,

Iqbal²,

Ahmed³

et al. 2019

JFNR

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Tomato, botanically known as Lycopersicon esculentum, is a food crop used throughout world in different cultures. Traditionally, various cardiovascular and inflammatory ailments are cured by fruit of this plant. But this has been done without any knowledge about its exact mechanism in these diseases, especially in thrombotic conditions. This study has been designed to investigate the potential mechanisms used by Lycopersicon esculentum fruit to provide relief in these diseases. A crude fraction of Lycopersicon esculentum fruits was prepared and then separated into n-hexane, chloroform and aqueous fractions. These fractions were screened for the presence of activities against arachidonic acid (AA) metabolism and agonist-induced human platelet aggregation. These fractions were also investigated for their potential to enhance the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Platelet aggregation was monitored using turbidometric principle, while AA metabolism was studied using radiolabelled AA. Antioxidant enzymes were measured by commercial kits using spectrophotometer. The aqueous fraction of Lycopersicon esculentum was mostly active against cyclooxygenase pathway of AA metabolism while chloroform was the only fraction possessing significant activity against lipoxygenase pathway. Aqueous and n-hexane fraction seem to have concentrated compounds responsible for elevating SOD activity while n-hexane was the most potent against PAF and the only fraction exhibiting potent activity against collagen-induced platelet aggregation. Compounds responsible for elevating GPx activity seems to be distributed throughout various fractions of tomato. The results demonstrate that anti-inflammatory and cardiovascular effects of Lycopersicon esculentum are mediated through multiple pathways. The compounds responsible for these pharmacological actions were however, distributed throughout various fractions of Lycopersicon esculentum.

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“…Lycopene content increases during ripening, as the concentration of chlorophylls decrease, and it is higher in the pericarp [ 43 , 44 ]. Lycopene is a strong antioxidant compound, with a very important role in the prevention of several diseases [ 44 , 45 ].…”

Section: Purple Tomatoes: Their Origins and Specificitiesmentioning

confidence: 99%

Anthocyanins from Purple Tomatoes as Novel Antioxidants to Promote Human Health

Gonzali

Perata

2020

Antioxidants

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Anthocyanins are plant secondary metabolites belonging to the class of polyphenols, whose beneficial roles in the prevention and treatment of several important human diseases have been demonstrated in many epidemiological studies. Their intake through diet strictly depends on the eating habits, as anthocyanins are contained in red and purple fruit and vegetables as well as in some processed foods and beverages, such as red wine. Genetic engineering and breeding programs have been recently carried out to increase the content of anthocyanins in candidate plant species which cannot offer satisfactory levels of these precious compounds. Tomato (Solanum lycopersicum) is a vegetable commodity where these strategies have resulted in success, leading to the production of new anthocyanin-rich fruit varieties, some of which are already marketed. These varieties produce purple fruits with a high nutraceutical value, combining the health benefits of the anthocyanins to the other classical tomato phytochemicals, particularly carotenoids. The antioxidant capacity in tomato purple fruits is higher than in non-anthocyanin tomatoes and their healthy role has already been demonstrated in both in vitro and in vivo studies. Recent evidence has indicated a particular capacity of tomato fruit anthocyanins to act as scavengers of harmful reactive chemical species and inhibitors of proliferating cancer cells, as well as anti-inflammatory molecules.

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Lycopene and Vascular Health

Cited by 152 publications

References 135 publications

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Antiplatelet and Antioxidant Activities of Tomato

Anthocyanins from Purple Tomatoes as Novel Antioxidants to Promote Human Health

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