Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia

Babaei, Atefeh; Asadpour, Reza; Mansouri, Kamran; Sabrivand, Adel; Kazemi‐Darabadi, Siamak

doi:10.1002/fsn3.2762

Cited by 11 publications

(7 citation statements)

References 81 publications

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“…Lycopene shielded sperm and testicular tissue against oxidative stress-induced death. In contrast to varicocele groups, lycopene groups had higher concentrations, higher survivability rates, and more intact membranes [39] .…”

Section: Non Oxidative Mechanismsmentioning

confidence: 65%

Effects of Lycopene on Sperm Parameter in Healthy Male: A Review

et al. 2023

IJFMR

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Infertility is an ability of couple to have a baby after one year of unprotected intercourse affects 48.5million couple in worldwide. Out one of four couple are affected by infertility. A minimum 30 million men world-wide are infertile and male factor are responsible for approximately 20-30% in all infertile cases. It is now understood that oxidative stress plays a significant role in the aetiology of male infertility. Reactive oxygen species (ROS) in excess lead to an oxidative stress condition that reduces sperm viability and motility by causing DNA damage, apoptosis, and lipid peroxidation of the sperm membrane. Increased ROS levels are a crucial role in idiopathic male factor infertility, which is a disease that is becoming more prevalent in society today. Due to its antioxidant qualities, lycopene, the most effective singlet oxygen quencher of all carotenoids, may be used to treat male infertility. Lycopene may minimise the occurrence of oxidative stress and, consequently, the harm that would otherwise be done to spermatozoa by interacting with and neutralising free radicals. We have analysed data from a number of sources and provided information regarding lycopene and its impact on male infertility in this review paper. The focus of this review is on how lycopene affects sperm parameters in healthy men.

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Section: Non Oxidative Mechanismsmentioning

confidence: 65%

Effects of Lycopene on Sperm Parameter in Healthy Male: A Review

et al. 2023

IJFMR

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“…From the evaluation of observational studies, a healthy diet rich in, among the other nutrients, lycopene was associated with high semen quality parameters [43]. Furthermore, in experimental varicocele, the administration of lycopene alone improved the quality of sperm owing to its antioxidant activity [10,12] and to the reduction of apoptosis [10,13,44]. No data are currently available on the association of lycopene with other substances in experimental varicocele.…”

Section: Discussionmentioning

confidence: 99%

“…The outcomes of different substances on the biochemical and morphological damages induced in testes by experimental varicocele were studied in the last years [7,[9][10][11][12][13][14][15]. In particular, the effects of lycopene and selenium (Se) were evaluated.…”

Section: Introductionmentioning

confidence: 99%

Positive Effects of the Nutraceutical Association of Lycopene and Selenium in Experimental Varicocele

Freni,

Pallio,

Marini

et al. 2023

IJMS

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Many natural substances commonly found in healthy diets have been studied for their potential to reduce male infertility associated with varicocele. A positive role of selenium (Se) or lycopene alone was demonstrated in experimental varicocele, while no data are available on their association. One group of male Sprague–Dawley rats was sham operated and daily treated with Se (3 mg/kg, i.p.), lycopene (1 mg/kg, i.p.), or their association. A second group underwent surgery to induce varicocele. Sham and half of the varicocele animals were sacrificed after twenty-eight days, while the residual animals were treated for one more month and then sacrificed. In varicocele animals, testosterone levels and testes weight were reduced, Hypoxia Inducible Factor-1α (HIF-1α) expression was absent in the tubules and increased in Leydig cells, caspare-3 was increased, seminiferous epithelium showed evident structural changes, and many apoptotic germ cells were demonstrated with TUNEL assay. The treatment with lycopene or Se alone significantly increased testis weight and testosterone levels, reduced apoptosis and caspase-3 expression, improved the tubular organization, decreased HIF-1α positivity of Leydig cells, and restored its tubular positivity. Lycopene or Se association showed a better influence on all biochemical and morphological parameters. Therefore, the nutraceutical association of lycopene plus Se might be considered a possible therapeutic tool, together with surgery, in the treatment of male infertility. However, long-term experimental and clinical studies are necessary to evaluate sperm quantity and quality.

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“…ROS-induced oxidative stress is a primary contributor to various reproductive complications [ 208 ]. In varicocele-induced rats, supplemental lycopene has shown to protect sperm against DNA damage by mediating upregulation of antioxidant responses that quenched ROS, which manifested with improved sperm viability, Johnson's score, membrane integrity, and the expression of B-cell lymphoma 2-associated X-protein (BAX) [ 209 ]. Similarly, in men with oligozoospermia, supplemental lycopene for 12 weeks at 25 mg/kg body weight attenuated oxidative stress and improved sperm quality [ 52 ].…”

Section: Biological Activities Of Lycopenementioning

confidence: 99%

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Shafe,

Gumede,

Nyakudya

et al. 2024

Journal of Nutrition and Metabolism

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Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used as a dietary supplement. In vitro and in vivo, lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions and diseases including inflammation, obesity, and diabetes mellitus. Lycopene has been shown to alleviate metabolic diseases that affect the bone, eye, kidney, liver, lungs, heart, and nervous system. This review presents the state of the art regarding lycopene’s health benefits and its potential applications in health system delivery. Furthermore, lycopene’s protective effects against toxins, safety in its use, and possible toxicity are explored.

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Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia

Cited by 11 publications

References 81 publications

Effects of Lycopene on Sperm Parameter in Healthy Male: A Review

Effects of Lycopene on Sperm Parameter in Healthy Male: A Review

Positive Effects of the Nutraceutical Association of Lycopene and Selenium in Experimental Varicocele

Lycopene: A Potent Antioxidant with Multiple Health Benefits

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