Lycopene in the management of oral lichen planus: A placebo-controlled study

Abstract

Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

“…In our study, complete remission was observed in 66.7% (n=10) and partial remission in 33.4% (n=5) of patients after eight weeks of treatment with prednisolone 40 mg/day along with tapered doses, which was more or less similar to the results reported by Carbone M et al [24] A double blind placebo controlled randomized clinical trial conducted by Saawar N et al [6] transformation (up to 0.2-2%) as compared to another forms. [25,26] Therefore, it may be presumed that lycopene and prednisolone may decrease the risk of malignant transformation in OLP.…”

“…[6,10,11] Daily intake of 3.7 -7 mg may be sufficient to maintain circulating levels of lycopene at levels sufficient to combat oxidative stress, to reduce lipid peroxidation, to decrease inflammation and TNF-α production [19,20,21,22] and the subject with low baseline lycopene levels respond better to low doses of lycopene than the subjects with elevated baseline levels of lycopene. [15] Single oral dose administration is possible because the half-life of lycopene is 2-3 days.…”

“…[6] In literature, lycopene has profound benefits in various oral mucosal lesions such as oral submucous fibrosis, leukoplakia, OLP and periodontal diseases. [6,10,11,12] The main purpose of the study was to evaluate and compare the efficacy of lycopene with prednisolone in the management of OLP. This study was motivated by the need for a monotherapeutic agent with a minimal or no reported adverse effects and act as a safe effective alternative to steroids for long-term use in treatment of OLP.…”

“…[6] Several antigen-specific and non-specific inflammatory mechanisms are involved in its pathogenesis. [7] Evidence points out that the disease is an immunological origin triggered by an unknown antigen which alters the basal keratinocytes, thereby activating auto-cytotoxic T lymphocytes.…”

Medical Management of Oral Lichen Planus: A Systematic Review

“…Other treatments included: aloe vera in three trials [21,30,31], hyaluronic acid [26], curcuminoids as adjunctive treatment to prednisone [18], Bacillus Calmette-Guerin polysaccharide nucleic acid [28], topical retinoic acid [6], topical thalidomide [29], lycopene [32], topical isotretinoin [12], ignatia [25] & MuGard [37].…”