Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB

Chiang, Han-Sun; Wu, Wen‐Bin; Fang, Jia‐You; Chen, Der-Fang; Chen, Bing‐Huei; Chen, Ying-Ting; Hung, Chi‐Feng

doi:10.1016/j.lfs.2007.09.018

Cited by 34 publications

(21 citation statements)

References 20 publications

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“…Mounting data suggest that lycopenebinding region exists within PDGF and is located at loop 2 region [108]. Consistent with same line, lycopene restricts PDGF-BB-induced cellular migration through inhibition of PI3K/Akt, ERK and p38 activation [109,110].…”

Section: Pdgf As a Major Challenge In Translational Oncologysupporting

confidence: 71%

PDGF: the nuts and bolts of signalling toolbox

et al. 2011

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PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development; however, if the unleashed potentials lead astray, it brings forth tumourigenesis. Conventionally, it has been assumed that the components of this signalling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways, and other components crosstalk to each other through multiple mechanisms. It is important to note that metastatic cascade is an intricate process that we have only begun to understand in recent years. Many of the early steps of this PDGF cascade are not readily targetable in the clinic. In this review, we will unravel the paradoxes with reference to mitrons and cellular plasticity and discuss how disruption of signalling cascade triggers cellular proliferation phase transition and metastasis. We will also focus on the therapeutic interventions to counteract resultant molecular disorders.

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Section: Pdgf As a Major Challenge In Translational Oncologysupporting

confidence: 71%

PDGF: the nuts and bolts of signalling toolbox

et al. 2011

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“…Since PDGF-BB facilitates the growth, invasion and metastasis of melanoma, inhibition of these PDGF-BB effects can be a mechanism for arresting melanoma progression. In vitro studies with the human foreskin fibroblast cell line Hs68 and the human metastatic melanoma cell line A2058 both individually and in a co-culture system indicate that lycopene can inhibit PDGF-BB induced human Hs68 skin fibroblast migration, attenuate PDGF-BB induced phosphorylation, and reduce PDGF-BB induced signaling [ 43 ]. In addition, lycopene was shown to bind to PDGF-BB in human plasma.…”

Section: Growth Factors and Signaling Pathways: Platelet-derived Growmentioning

confidence: 99%

Multitargeted therapy of cancer by lycopene

2008

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An acyclic, non-provitamin A carotene, lycopene is responsible for the red pigmentation of ripe tomatoes and some other edible fruits such as watermelon and papaya. Lycopene is also a potent antioxidant and scavenger of free radicals. Multiple retrospective and prospective epidemiological studies have indicated that the consumption of tomato products containing lycopene is associated with a reduced risk of prostate cancer. These epidemiological studies are supported by numerous in vitro assays using cell cultures that show anti-cancer activities and cancer chemoprevention activities of lycopene in many cell lines including prostate cancer cells. These activities include inducing apoptosis, inhibiting metastasis, preventing oxidative stress, and up-regulating the antioxidant response element so that cells can produce cytoprotective enzymes against prooxidants and electrophiles. In vivo animal studies and Phase I and II clinical trials have shown that lycopene supplements are non-toxic and that lycopene is orally bioavailable. Furthermore, lycopene is concentrated in prostate tissue and localized to the nucleus. In addition, some oxygenated metabolites of lycopene have been identified, and might be active as chemoprevention agents. The next phase of research concerning lycopene as a chemoprevention agent will be Phase II clinical trials of efficacy that are placebo-controlled, randomized and double blind. These clinical trials are required to establish the efficacy of lycopene supplementation.

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“…Moreover, lycopene inhibits SMC and fibroblast migration by reducing PDGF-AA and PDGF-AB signalling as measured by PDGFR α phosphorylation and the activation of downstream kinases [49]. Chiang et al [50] have shown that lycopene significantly inhibits the fibroblast migration induced by melanoma tumour cells, indicating that lycopene interferes with stroma-tumour cell interactions. Furthermore, lycopene has been suggested to bind to the PDGF secreted by melanoma cells, and it might inhibit PDGF-induced fibroblast migration.…”

Section: Potential Mechanisms Of Actions Of Lycopenementioning

confidence: 99%

Multiple Molecular and Cellular Mechanisms of Action of Lycopene in Cancer Inhibition

Trejo-Solís

Pedraza‐Chaverrí

Torres-Ramos

et al. 2013

Evidence-Based Complementary and Alternative Medicine

120

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Epidemiological studies suggest that including fruits, vegetables, and whole grains in regular dietary intake might prevent and reverse cellular carcinogenesis, reducing the incidence of primary tumours. Bioactive components present in food can simultaneously modulate more than one carcinogenic process, including cancer metabolism, hormonal balance, transcriptional activity, cell-cycle control, apoptosis, inflammation, angiogenesis and metastasis. Some studies have shown an inverse correlation between a diet rich in fruits, vegetables, and carotenoids and a low incidence of different types of cancer. Lycopene, the predominant carotenoid found in tomatoes, exhibits a high antioxidant capacity and has been shown to prevent cancer, as evidenced by clinical trials and studies in cell culture and animal models. In vitro studies have shown that lycopene treatment can selectively arrest cell growth and induce apoptosis in cancer cells without affecting normal cells. In vivo studies have revealed that lycopene treatment inhibits tumour growth in the liver, lung, prostate, breast, and colon. Clinical studies have shown that lycopene protects against prostate cancer. One of the main challenges in cancer prevention is the integration of new molecular findings into clinical practice. Thus, the identification of molecular biomarkers associated with lycopene levels is essential for improving our understanding of the mechanisms underlying its antineoplastic activity.

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Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB

Cited by 34 publications

References 20 publications

PDGF: the nuts and bolts of signalling toolbox

PDGF: the nuts and bolts of signalling toolbox

Multitargeted therapy of cancer by lycopene

Multiple Molecular and Cellular Mechanisms of Action of Lycopene in Cancer Inhibition

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