Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue

Gouranton, Erwan; Thabuis, Clémentine; Riollet, Céline; Malezet-Desmoulins, Christiane; Yazidi, Claire El; Amiot, Marie-Josèphe; Borel, Patrick; Landrier, Jean‐François

doi:10.1016/j.jnutbio.2010.04.016

Cited by 123 publications

(113 citation statements)

References 53 publications

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“…NRF2, NFĸB, PPAR and RAR activation pathways seem to be the key steps for these observed antioxidant effects in various organs [87,88,89]. We propose that carotenoids (pro-vitamin A carotenoids as well as non-pro-vitamin A carotenoids) are metabolized under radical/oxidative conditions to bioactive carotenoid metabolites which can activate RAR- and/or PPAR-mediated signalling and thereby block/ameliorate NFĸB signalling and possibly other pro-oxidant and pro-inflammatory pathways as previously described for lycopene [90]. Another example is the recently identified apolycopenoids which display this potent anti-inflammatory potential [32].…”

Section: Introductionmentioning

confidence: 88%

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Rühl

2013

Int Arch Allergy Immunol

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Carotenoids are important derivatives of the human diet and occur in high concentrations in the human organism. Various carotenoids are also present in human breast milk and are transferred to breast-fed children. The alternative to breastfeeding is supplementation with an infant milk formula, but these formulas contain only a limited variety of carotenoids. Our question is: ‘What is the function of various carotenoids in human nutrition with a special emphasis on child development and the development of atopy?’ In this review, the mechanisms of action of the most important non-pro-vitamin A and pro-vitamin A carotenoids: α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, lycopene and retinoids are discussed. In summary, the combination of carotenoids, especially lycopene, seems to be of great importance, and exclusive usage of β-carotene in infant formula may yield in an increased atopy prevalence mediated in various target organs like the skin, lungs and immune competent cells. We conclude that the determination of novel bioactive metabolites of various carotenoids, at various stages in different organs during atopy development, might be the key to understanding the potential importance of carotenoids on atopy development.

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Section: Introductionmentioning

confidence: 88%

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Rühl

2013

Int Arch Allergy Immunol

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“…Particular interest has focused on apo-lycopenals, which can modulate cellular function via the antioxidant response element transcription system (64) and inhibit tumourigenesis (83) . Apo-10′-lycopenoic acid can also modulate adipocyte activity via the retinoic acid receptors (84) . Interestingly, lycopene has recently been found to reduce the formation of advanced glycation end products in HK-2 cells and in rat kidneys, which led to a concomitant decrease in the expression of their receptors and NF-κB and matrix metalloproteinase 2 (85) .…”

Section: Mechanistic Studiesmentioning

confidence: 99%

Cardiovascular benefits of lycopene: fantasy or reality?

et al. 2016

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Epidemiological evidence indicates that high consumption of tomatoes and tomato-based products reduces the risk of chronic diseases such as CVD and cancer. Such potential benefits are often ascribed to high concentrations of lycopene present in tomato products. Mainly from the results of in vitro studies, potential biological mechanisms by which carotenoids could protect against heart disease and cancer have been suggested. These include cholesterol reduction, inhibition of oxidation processes, modulation of inflammatory markers, enhanced intercellular communication, inhibition of tumourigenesis and induction of apoptosis, metabolism to retinoids and antiangiogenic effects. However, with regard to CVD, results from intervention studies gave mixed results. Over fifty human intervention trials with lycopene supplements or tomato-based products have been conducted to date, the majority being underpowered. Many showed some beneficial effects but mostly on non-established cardiovascular risk markers such as lipid peroxidation, DNA oxidative damage, platelet activation and inflammatory markers. Only a few studies showed improvement in lipid profiles, C reactive protein and blood pressure. However, recent findings indicate that lycopene could exert cardiovascular protection by lowering HDL-associated inflammation, as well as by modulating HDL functionality towards an antiatherogenic phenotype. Furthermore, in vitro studies indicate that lycopene could modulate T lymphocyte activity, which would also inhibit atherogenic processes and confer cardiovascular protection. These findings also suggest that HDL functionality deserves further consideration as a potential early marker for CVD risk, modifiable by dietary factors such as lycopene.

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“…것으로 보고되었다 (Gouranton et al, 2011). 닭에서 베타카 로틴(β-carotene)이 사료의 첨가제로서 산화적 스트레스 완 화 (Palozza et al, 2000)와 계란 난황으로의 전이로 착색도가 크게 개선되었다는 보고도 있다 (Damron et al, 1984).…”

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Effects of Lycopene on the Expression of Lipid Metabolism, Glucose Transport and Pro-Inflammatory Related Genes in Chickens

Jang¹,

Moon

2015

Korean Journal of Poultry Science

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The present study aimed to investigate the effects of lycopene on hepatic metabolic-and immune-related gene expression in laying hens. A total of 48 25-week-old White Leghorn hens were randomly allocated into four groups consisting of four replicates of three birds: control (basal diet), T1 (basal diet + 10 mg/kg of tomato powder-containing lycopene), T2 (basal diet + 10 mg/kg of micelles of tomato powder-containing lycopene), and T3 (basal diet + 10 mg/kg of purified lycopene). Chickens were fed ad libitum for 5 weeks, and then total RNA was extracted from the livers for quantitative RT-PCR analysis. Peroxisome proliferator-activated receptor ɣ (PPARɣ) expression was decreased in the liver of chickens after lycopene supplementation (P<0.05). Micellar lycopene supplementation decreased the expression of PPARɣ target genes including fatty acid binding protein 4 (FABP4) and fatty acids synthase (FASN) in the T2 group (P<0.05). Sterol regulatory element-binding protein 2 (SREBP2) and C/EBP-ɑ were also downregulated in hens fed with micellar lycopene (P<0.05). Glucose transporter 8 (GLUT-8) was upregulated in the T2 and T3 groups (P<0.05). However, the expression of carnitine palmitoyltransferase 1 (CPT-1) was not changed by lycopene supplementation. Pro-inflammatory cytokines such as tumor necrosis factor ɑ (TNF-ɑ) and interleukin 6 (IL-6) were downregulated by lycopene supplementation (P<0.05). These data suggest that the type of lycopene supplementation is critical and that micelles of tomato powder-containing lycopene may play an important role in the modulation of lipid metabolism and immunity in chickens.

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Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue

Cited by 123 publications

References 53 publications

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Cardiovascular benefits of lycopene: fantasy or reality?

Effects of Lycopene on the Expression of Lipid Metabolism, Glucose Transport and Pro-Inflammatory Related Genes in Chickens

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