Lycopene loaded polylactic acid (PLA) and PLA/copolymer electrospun nanofibers, synthesis, characterization, and control release

Abstract

The effect of different copolymers on the morphological and encapsulating properties of polylactic acid (PLA) nano(micro)fiber and potential of the fibers for controlling lycopene release rate were studied. The lycopene loaded fibers developed from PLA and different copolymers including polyethylene oxide (PEO), polyacrylic acid, and cellulose acetate (CA) using electrospinning. Diameters and morphology of fabricated fibers are assessed using scanning electron microscopy. Encapsulation of the lycopene in the fibers was confirmed using fluorescence microscopy and Fourier‐transform infrared spectroscopy. Differential scanning calorimetry showed the thermal stability of the encapsulated lycopene. Incorporation of PEO changed the morphology of the fibers and let to fast release of encapsulated lycopene. In presence of CA the fine fiber with surface smooth morphology was produced and the releaase rate of lycopene was decreased which, can be related to good compatibility of PLA and CA that prevent the release of lycopene. Practical applications The use of electrospun ultrafine fibers as drug carriers could be promising in the future for biomedical applications, especially postoperative local chemotherapy and controlled drug release from electrospun fibers has found important biomedical applications in wound healing, transdermal delivery, and tissue engineering. Characterization of forming solution related to properties of produced fibers as well as release properties of embedded functionals are necessary.

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

“…It also could be a promising candidate for postoperative chemotherapy. Hajikhani et al reported the encapsulating properties of nanofibers derived from electrospinning of copolymers of PAA, polylactic acid, cellulose acetate, and polyethylene oxide for controlled release lycopene [ 230 ]. Khajeh et al reported using biocompatible nanofibers derived from electrospinning of PAA, poloxamer, and polyurethane for wound dressing.…”

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

“…chitosan [152][153][154][155][156], collagen [157][158][159][160], SF [161][162][163][164], gelatin [165][166][167][168][169][170]) and synthetic polymers (e.g. PGA [171][172][173], poly lactic acid (PLA) [174][175][176][177][178][179], PLGA [180][181][182][183][184][185][186][187][188], poly vinylpyrrolidone (PVP) [77,[189][190][191][192][193][194], PCL [195][196][197][198][199][200]<...…”

Gelatin-Based and Gelatin-Free Electrospun Fibers of Lycopene/Cyclodextrin Inclusion Complexes with Potent Antioxidant Activity

“…Lycopene could be encapsulated in a variety of materials, such as hydrogels, 8 films, 9 nanoparticles, 10 nanoliposomes, 11 and electrospun fibers. 12 In particular, the encapsulation of lycopene into electrospun fibers can offer great benefits including versatile encapsulation routes, ease of fabrication, enhanced stability, controlled release, and combination therapies. In this regard, due to the poor water solubility of lycopene, organic solvents, acidic solutions, or emulsion routes are commonly used for its encapsulation into electrospun fibers or electrosprayed beads.…”

“…Lycopene has also been encapsulated in polylactic acid (PLA) and PLA-based electrospun fibers. 12 Differential scanning calorimetry was used to validate the change in the thermal stability of the encapsulated lycopene. The addition of cellulose acetate affected the fiber shape and reduced the lycopene release rate compared to other polymers such as poly(acrylic acid) and poly(ethylene oxide).…”

“…Given that lycopene is very sensitive to light, oxygen, and heat, encapsulating lycopene into materials while increasing its stability and loading capacity is of tremendous importance. Lycopene could be encapsulated in a variety of materials, such as hydrogels, films, nanoparticles, nanoliposomes, and electrospun fibers . In particular, the encapsulation of lycopene into electrospun fibers can offer great benefits including versatile encapsulation routes, ease of fabrication, enhanced stability, controlled release, and combination therapies.…”