Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

“…The Pink1/Parkin pathway could govern mitochondrial quality control, mediating mitophagy to maintain mitochondrial fidelity. 26 The level of Pink1 was raised with ATZ exposure (Fig. 5H).…”

“…The Pink1/Parkin pathway could mediate mitophagy in mammals, in response to mitochondrial quality control. 26 Parkin should be translocated into the impaired mitochondria to induce mitophagy. Thus, the level of Tom20 (a marker of the outer membrane of mitochondria) with Parkin overlapping was tested.…”

Lycopene regulates the mitochondrial unfolded protein response to prevent DEHP-induced cardiac mitochondrial damage in mice

“…A large number of studies have shown that DEHP treatment can lead to mitochondrial damage. 53,56 In addition, LYC, as an antioxidant, has a good effect on alleviating mitochondrial damage. 57,58 These results are consistent with this experiment.…”

Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases

“…Mitophagy elevation might be a protective mechanism against oxidative stress-mediated ROS production through the SIRT1-PGC-1α axis (Liang et al, 2020 ; Zhao et al, 2022 ). This axis is also involved in C2C12 myotubes (Chang et al, 2021a ), cardiac dysfunction in doxorubicin-induced cardiomyopathy (Wang et al, 2021 ), and podocyte injury in diabetic nephropathy (Zhou et al, 2019 ).…”