Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis

Li, Li; Zhang, Zao; Yang, Qian; Ning, Meiying

doi:10.1016/j.lfs.2019.06.003

Cited by 22 publications

(15 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Professor Einstein resulted in the isolation of 23 known AA , and a new alkaloid (24). The compounds were analyzed by various spectroscopic methods (GC-MS, LC-MS, and 1D and 2D NMR spectroscopy) and identified by comparison with literature data as masonine (1) [22], homolycorine (2) [23], ismine (3) [24], caranine (4) [25], galanthamine (5) [26], narwedine (6) [27], lycoraminone (7) [28], pluviine (8) [25], incartine (9) [29], galanthine (10) [30], lycoramine (11) [26], epinorgalanthamine (12) [31], norlycoramine (13) [32], haemanthamine (14) [32], hippeastrine (15) [33], epimaritidine (16) [34], lycorine (17) [35], tazettine (18) [36], eugenine (19) [37], norpluviine (20) [38], 9-O-demethylmaritidine (21) [39], pancracine (22) [40], and 9-O-demethylhomolycorine (23) [23] (Figure 1). The alkaloids that were isolated were representatives of the homolycorine (1,2,15,19,23), galanthamine (5,6,…”

Section: Isolation and Identification Of Amaryllidaceae Alkaloids Fromentioning

confidence: 99%

“…Simultaneously, the anti-invasive and anti-metastatic effects of some plant alkaloids have been described [13,14]. For this reason, substances of natural origin represent a valuable source of potential anticancer drugs; many AAs are very promising anticancer compounds, for example, the widely studied haemanthamine [15] and lycorine [16]. A well thought-out basic study of natural compounds can serve as a springboard for clinical therapy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity

Breiterová

Koutová

Maříková

et al. 2020

Plants

View full text Add to dashboard Cite

In this detailed phytochemical study of Narcissus cv. Professor Einstein, we isolated 23 previously known Amaryllidaceae alkaloids (1–23) of several structural types and one previously undescribed alkaloid, 7-oxonorpluviine. The chemical structures were identified by various spectroscopic methods (GC-MS, LC-MS, 1D, and 2D NMR spectroscopy) and were compared with literature data. Alkaloids which had not previously been isolated and studied for cytotoxicity before and which were obtained in sufficient amounts were assayed for their cytotoxic activity on a panel of human cancer cell lines of different histotype. Above that, MRC-5 human fibroblasts were used as a control noncancerous cell line to determine the general toxicity of the tested compounds. The cytotoxicity of the tested alkaloids was evaluated using the WST-1 metabolic activity assay. The growth of all studied cancer cell lines was inhibited by pancracine (montanine-type alkaloid), with IC50 values which were in the range of 2.20 to 5.15 µM.

show abstract

Section: Isolation and Identification Of Amaryllidaceae Alkaloids Fromentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity

Breiterová

Koutová

Maříková

et al. 2020

Plants

View full text Add to dashboard Cite

show abstract

“…Feng et al confirmed miR-186 significantly upregulated in lung adenocarcinoma samples and cells, in comparison with the adjacent noncancerous samples and normal lung epithelial cells BEAS-IB (13). However, several groups reported that the levels of miR-186 were markedly decreased in NSCLC samples and cells (14)(15)(16)(17)(18)(19)(20). Prostate cancer is the most common non-skin cancer in males, with there being ∼1.6 million cases worldwide annually (60).…”

Section: Altered Expressions Of Mir-186 In Different Cancersmentioning

confidence: 99%

The Dual Role of miR-186 in Cancers: Oncomir Battling With Tumor Suppressor miRNA

et al. 2020

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are a class of small non-coding RNAs which regulate gene expression at post-transcriptional level. Alterations of miR-186 expression were demonstrated in numerous cancers, shown to play a vital role in oncogenesis, invasion, metastasis, apoptosis, and drug resistance. MiR-186 was documented as a tumor suppressor miRNA in the majority of studies, while conflicting reports verified miR-186 as an oncomir. The contradictory role in cancers may impede the application of miR-186, as well as other dual-functional miRNAs, as a diagnostic and therapeutic target. This review emphasizes the alterations and functions of miR-186 in cancers and discusses the mechanisms behind the contradictory findings. Among these, target abundance and dose-dependent effects of miR-186 are highlighted. The paper aims to review the challenges involved in developing diagnostic and therapeutic strategies for cancer treatment based on dual-functional miRNAs.

show abstract

“…Furthermore, the PPI network of the downstream DEmRNAs was constructed and the genes of the highest degrees were obtained, including CDK1, TOP2A and KIF11, which were reported to take a remarkable part in proliferation and drug resistance [42][43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analyses to identify LINC02310 as an enhancer in lung adenocarcinoma

Zhao

Wang

Luo

et al. 2020

Preprint

View full text Add to dashboard Cite

Lung adenocarcinoma (LADC) is a major subtype of non-small cell lung cancer (NSCLC) and has one of the highest mortality rates. An increasing number of long non-coding RNAs (lncRNAs) were reported to be associated with the occurrence and progression of LADC. In order to find potential biomarkers for LADC therapies among lncRNAs, 2431 differentially expressed lncRNAs (DElncRNAs) over LADC and adjacent normal samples were identified from The Cancer Genome Atlas (TCGA) expression data. Lnc-YARS2-5, lnc-NPR3-2 and LINC02310, which were the top-3 significant DElncRNAs related to overall survival, were selected for further analysis. Their overexpression indicated poor prognostic. PCR experimental results also showed that they were mainly up-regulated in the LADC tissues from Xiangya Hospital. Clinical analysis of these cases suggested that LINC02310 was significantly correlated with TNM-stage and T-stage, which was further validated by the clinical analysis based on TCGA. Reasonably, we assumed that LINC02310 acted as an enhancer in LADC, which was demonstrated by CCK-8 assay and colony formation assay. Moreover, 3 targeted miRNAs of LINC02310 and 414 downstream differentially expressed mRNAs (DEmRNAs) were predicted. The competing endogenous RNA (ceRNA) regulatory network was constructed with LINC02310, 3 miRNAs and 113 DEmRNAs involved. The downstream mRNAs were then enriched in 405 GO terms and 11 KEGG pathways, which revealed their potential functions and mechanisms. The protein-protein interaction (PPI) network showed the relationships between the downstream mRNAs. In conclusion, this study verified LINC02310 as an enhancer in LADC and conducted comprehensive analyses on its target miRNAs and downstream mRNAs.

show abstract

Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis

Cited by 22 publications

References 49 publications

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity

The Dual Role of miR-186 in Cancers: Oncomir Battling With Tumor Suppressor miRNA

Comprehensive analyses to identify LINC02310 as an enhancer in lung adenocarcinoma

Contact Info

Product

Resources

About