“…Clinical studies show evidence of persistent B. burgdorferi infection in humans [ 34 , 35 , 36 ]. Although there are some overlapping symptoms of CLD and acute Lyme disease, including pain, polyradiculoneuropathy [ 37 ] fatigue, and sleep disturbance [ 38 ], CLD causes some symptoms that differentiate it from acute Lyme disease, including functional and structural brain abnormalities [ 39 ], cognitive impairment [ 13 , 40 ], neuroborreliosis [ 14 ], musculoskeletal and neurological morbidity, vision impairment [ 41 ], depression [ 9 , 42 ] (which can lead to suicide) [ 43 ], cardiac issues (including Lyme carditis) [ 44 , 45 ], gastrointestinal issues [ 46 , 47 ], joint pain, and Lyme arthritis [ 48 , 49 ]. The number of Lyme disease patients with lingering symptoms in the US was projected to be as high as 1,944,189 in 2020 [ 50 ].…”