Lyme disease associated with optic neuropathy

Schechter, Stephen L.

doi:10.1016/0002-9343(86)90198-1

Cited by 54 publications

(5 citation statements)

References 7 publications

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“…Horner's syndrome, idiopathic intracranial hypertension, optic disc edema, optic neuritis, optic neuropathy and optic atrophy are neuro- ophthalmological complications (2). AION as a complication of neuroborreliosis has been described in five patients (6)(7)(8)(9)(10). Antibiotic therapy is recommended in all three stages.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Lesion following Neuroborreliosis: A Case Report

Burkhard

Gleichmann²,

Wilhelm

2001

European Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Optic Nerve Lesion following Neuroborreliosis: A Case Report

Burkhard

Gleichmann²,

Wilhelm

2001

European Journal of Ophthalmology

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“…Lyme disease is caused by Borrelia burgdorferi, a spirochete carried by ticks. Ocular manifestations vary and include intraocular inflammation, retinal vasculitis, and ischemic optic neuropathy [32][33][34]. Additionally, the results of serum antibody titers to B. burgdorferi may vary one from laboratory to another, further complicating the diagnosis [35].…”

Section: Chorioretinal Infectionsmentioning

confidence: 99%

Retinitis Pigmentosa Masquerades: Case Series and Review of the Literature

Thenappan,

Nanda,

Lee

et al. 2023

JCM

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Retinitis pigmentosa (RP) displays a broad range of phenotypic variations, often overlapping with acquired retinal diseases. Timely recognition and differentiation of RP masquerades is paramount due to the treatable nature of many such conditions. This review seeks to present examples of pseudo-RP cases and provide a comprehensive overview of RP masquerades. We first present two pseudo-RP cases, including comprehensive clinical histories and multimodal retinal imaging, to highlight the important role of accurate diagnoses that subsequently steered effective intervention. Subsequently, we conduct an in-depth review of RP masquerades to provide valuable insights into their key distinguishing features and management considerations. The recent approval of ocular gene therapy and the development of investigational gene-based treatments have brought genetic testing to the forefront for RP patients. However, it is important to note that genetic testing currently lacks utility as a screening tool for inherited retinal diseases (IRDs), including RP. The integrity of a precise clinical assessment remains indispensable for the diagnosis of both RP and RP masquerade conditions, thereby facilitating prompt intervention and appropriate management strategies.

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“…Seitdem lieBen sich unterschiedliche Stamme von Borrelia burgdorferi in Nordamerika und Europa nachweisen [Barbour (und Mitarb. ), 1983a, 1986Hyde und Johnson, 1984;Wilske und Mitarb., 1986]. Zwischen 1980Zwischen und 1986 Der Krankheitsverlauf gliedert sich kunisch in drei Stadien, wobei im ersten Stadium Fieber, Kopfschmerzen, Muskelschmerzen, MUdigkeit, Erythema chronicum migrans (sog.…”

Section: Zusammenfassungunclassified

“…Dabei sind die Antikorper-Titer (1gM) niedrig, und die Diagnose ist hauptsachlich klinisch zu stellen (Afzelius, 1921;Craft und Mitarb., 1984;Editorial: Lyme Disease, 1987 Rich, 1985). Das zweite Stadium der Erkrankung scheint durch einen Antikorperanstieg (IgG und 1gM) gekennzeichnet zu sein, wobei nach Wochen bis Monaten generalisierte Muskel-und Gelenkschmerzen, Myokarditis, Purpura-Schönlein-Henoch, Erbrechen und Durchfall, Meningopolyneuritis, Funktionsbeeintrachtigung des ZNS mit demenzartigen Erscheinungen, Desorientierung und BewuBtseinsverlust, multiple Hirnnervenparesen, insbesondere em-oder beidseitige Fazialislahmungen auftreten kOnnen (Abfall des 1gM) (Ackermann und Mitarb., 1986a;Baumhackl und Mitarb., 1986;Pachner und Steere, 1985;Schiotfeldt und Fahrenkrug, 1988;Schmidt und Ackermann, 1985;Schmutzhard und Mitarb., 1986;Steere und Mitarb., 1983a;Stiernstedt und Mitarb., 1984, 1986. In der Mehrzahi der Fälle zeigen sich nur em bis zwei dieser moglichen klinischen Erscheinungen (Schmidt und Ackermann, 1985).…”

Section: Zusammenfassungunclassified

“…Photophobie, Diplopie (vergesellschaftet mit Okulomotorius-oder Abduzensparese), ischamische Opticusneuropathie, Neuritis N. optici, Unschärfe des Sehnerven und Stauungspapilte sowie foveale Pigmentepithelproliferationen, Iritis mit konsekutiver Panophthatmie, bilaterate Keratitis (Baum und Mitarb., 1988;Baumhackl und Mitarb., 1986;Pachner und Steere, 1985u. 1986Pfister und Mitarb., 1986;Schechter, 1986;Schmidt und Ackermann, 1985;Steere und Mitarb., 1983a;Wu und Mitarb., 1986). Markowitz und Steere (1986) (Johnson und Mitarb., 1984).…”

Section: Zusammenfassungunclassified

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Bilaterale akute konfluierende Chorioiditis disseminata bei Borrelia burgdorferi-Infektion

Wilk¹,

Bialasiewicz²,

Ruprecht³

et al. 1989

Klin Monatsbl Augenheilkd

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Two patients with bilateral extensive confluent choroidal lesions, exudative retinal detachments, positive lyme serology and a typical history are documented: A 32-year-old woman presented 14 days after a "flu-like" illness with bilateral acute extensive choroidal lesions and exudative retinal detachments (OD from 5 to 8:30 o'clock, OS from 5 to 8 o'clock, both including the macula) accompanied by a mild lymphocytic meningitis. The laboratory work-up revealed increased serum and CSF titers of antibodies against Borrelia burgdorferi (Lyme immunofluorescent test (IFT) and Lyme-IgM IFT) which declined after a 14-day treatment with doxycycline (200 mg/d), CSF titers non-detectable (serum IgG: from 1:640 to 1:320, serum IgM: from 1:40 to 1:20). A distinct improvement with visual acuity increasing from OD 0.2/OS 0.3 p to OD/OS 0.8 p was observed after seven days of treatment. A 40-year-old man with a 14-day history of tick-bite developed the same, though more severe ocular findings and a lymphocytic meningitis. The serological work-up revealed increased antibody titers against Borrelia burgdorferi (ELISA); the IgM titer was normal. After a 10-day treatment with penicillin, antibody titers against the spirochete decreased slightly and the patient's neurologic and ophthalmologic status improved dramatically. Five weeks after admission visual acuity was OD/OS 0.5 (compared to OD/OS 0.1) and has remained at 0.8 p (OD/OS) since the ninth week after onset. The clinical course of the disease and the decreasing lyme serology strongly suggest an infection with Borrelia burgdorferi. The authors propose thorough laboratory work-ups including tests for Lyme disease in selected patients with diffuse choroidal lesions.

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Lyme disease associated with optic neuropathy

Cited by 54 publications

References 7 publications

Optic Nerve Lesion following Neuroborreliosis: A Case Report

Optic Nerve Lesion following Neuroborreliosis: A Case Report

Retinitis Pigmentosa Masquerades: Case Series and Review of the Literature

Bilaterale akute konfluierende Chorioiditis disseminata bei Borrelia burgdorferi-Infektion

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