Lymph-Node???Based Malignant Lymphoma and Reactive Lymphadenopathy in Eosinophilic Fasciitis

Naschitz, Jochanan E.; Misselevich, Ines; Rosner, Itzhak; Yeshurun, Daniel; Weiner, P; Amar, Mary; Amato, Luciana; Ciompi, Maria Laura; Boss, J. H.

doi:10.1097/00000441-199911000-00011

Cited by 23 publications

(10 citation statements)

References 25 publications

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“…Although visceral organ involvement is infrequent, myopathy, peripheral neuropathy and carpal tunnel syndrome, inflammatory arthritis, autoimmune thyroiditis, and lymphadenopathy have all been reported in association with EF [24][25][26][27]. Of greatest potential concern is the development of hematologic abnormalities and myelodysplastic syndromes.…”

Section: Eosinophilic Fasciitismentioning

confidence: 99%

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Scleroderma-like cutaneous syndromes

Mori¹,

Kahari²,

Varga

2002

Curr Rheumatol Rep

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Several distinct entities associated with dermal fibrosis can mimic scleroderma/systemic sclerosis. The list of scleroderma-like conditions or scleroderma variants includes eosinophilic fasciitis, localized forms of scleroderma, scleredema and scleromyxedema, keloids, and environmental exposure-associated conditions including eosinophilia-myalgia syndrome and pseudosclerodermas induced by various drugs. Although these conditions are relatively uncommon, their accurate recognition is essential to avoid misdiagnosis and inappropriate therapy. The pathogenesis of these scleroderma variants appears to share similarities with each other and with that of scleroderma. Better understanding of scleroderma-like disorders is emerging through epidemiologic investigations, and in vivo and in vitro experimental research. Activation of eosinophils and disordered regulation of fibroblast collagen synthesis, apoptosis, and proliferation are recurrent findings in these disorders. The etiologic role of infection with Borrelia species or other microorganisms remains controversial. Cytokines such as transforming growth factor-beta, interleukin-4, interleukin-13, and connective tissue growth factor contribute to fibrosis in these disorders by inducing an accentuated and persistent fibrogenic response to tissue injury. The role of genetic factors in susceptibility and clinical expression of scleroderma-like conditions remains to be systematically addressed. Because of the relative rarity of these conditions, few well-controlled clinical treatment trials have been performed. In addition, there is no consensus on optimal management. Much anecdotal information and small clinical series indicate that phototherapy may have a role in the treatment of scleroderma-like conditions.

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Section: Eosinophilic Fasciitismentioning

confidence: 99%

“…Of greatest potential concern is the development of hematologic abnormalities and myelodysplastic syndromes. Aplastic anemia, hemolytic anemia, thrombocytopenia, lymphoma, and B lymphocytic leukemia have been described in patients with EF [24,[28][29][30][31]. The pathogenesis of the hematologic complications of EF is unknown.…”

Section: Eosinophilic Fasciitismentioning

confidence: 99%

Scleroderma-like cutaneous syndromes

Mori¹,

Kahari²,

Varga

2002

Curr Rheumatol Rep

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“…It has been reported that EF is usually related with various hematologic abnormalities, including myelodysplastic diseases and malignant lymphoproliferative disease3). It was demonstrated that the overall frequency of hematological disorders in EF was close to 10%4).…”

Section: Discussionmentioning

confidence: 95%

“…During acute period of the disease, most of the patients suffer from significant eosinophilia in peripheral blood, but is less commonly associated in affected tissues2). It has been reported that EF is usually related with various hematologic abnormalities, such as myelodysplastic syndrome and malignant lymphoproliferative disease3). The etiology of EF is still unclear, and its association with autoimmune disease has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic Fasciitis Associated with Autoimmune Thyroiditis

Hur

Lee

Uhm

et al. 2005

Korean J Intern Med

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Eosinophilic fasciitis (EF) is scleroderma-like disease without Raynaud's phenomenon or visceral involvement. It is characterized by painful swelling of the extremities, accompanied by rapid weight gain, fever and myalgia. The acute state of disease is associated with significant peripheral blood eosinophilia, an elevated erythrocyte sedimentation rate and hypergammaglobulinemia. EF is also frequently associated with hematological abnormalities, including malignant lymphoproliferative diseases, but rarely associated with autoimmune thyroiditis. In the present study we report a case of eosinophilic fasciitis associated with autoimmune thyroiditis.

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“…Nevertheless, a long lasting follow-up is mandatory in those patients with EF, and any adenopathy or symptom that suggests a possible complication will require a detailed study. 8 The relationship between EF and lymphoma has not yet been precisely defined, but some reported data may help to clarify it. Simon et al 7 observed that abnormal T-cell clones produce interleukin-5, which stimulates the production of eosinophils, described in patients with the hypereosinophilic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Fasciitis as a Manifestation of a Cutaneous T-Cell Lymphoma Not Otherwise Specified

Castellanos-González

Rodríguez²,

Echevarría³

et al. 2013

The American Journal of Dermatopathology

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Eosinophilic fasciitis (EF) is a rare entity characterized by symmetrical and painful thickness and induration of the skin, especially localized on forearms and thorax and generally accompanied by eosinophilia. Although several reports indicate the relationship between EF and hematological disorders such as aplastic anemia, polycythemia vera, or myelomonocytic leukemia, the association with lymphomas is extremely rare. Only a few cases of EF have been previously described preceding or concomitant to the Hodgkin disease, peripheral T-cell lymphoma, B-cell lymphoma, and mycosis fungoides. We report for the first time a 76-year-old man with an EF associated with a peripheral T-cell lymphoma not otherwise specified. We review the relationship between both conditions. In conclusion, we present a unique case of EF as a manifestation of a T-cell lymphoma not otherwise specified. The present case demonstrates the importance of clinical and radiological studies in those cases of EF to rule out a visceral, lymph node, or cutaneous lymphoma.

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Lymph-Node???Based Malignant Lymphoma and Reactive Lymphadenopathy in Eosinophilic Fasciitis

Cited by 23 publications

References 25 publications

Scleroderma-like cutaneous syndromes

Scleroderma-like cutaneous syndromes

Eosinophilic Fasciitis Associated with Autoimmune Thyroiditis

Eosinophilic Fasciitis as a Manifestation of a Cutaneous T-Cell Lymphoma Not Otherwise Specified

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